STRINGSTRING
MAPK10 MAPK10 RHOG RHOG LCP2 LCP2 ITGA4 ITGA4 CXCL8 CXCL8 NFATC3 NFATC3 RELA RELA ACTB ACTB RAC1 RAC1 WASF2 WASF2 RPS6KA1 RPS6KA1 WIPF2 WIPF2 MAP2K2 MAP2K2 AKT1 AKT1 IRAK4 IRAK4 AKT2 AKT2 PXN PXN WAS WAS GNAQ GNAQ MAPK3 MAPK3 IL6 IL6 TAB1 TAB1 SKAP2 SKAP2 ACTR2 ACTR2 PIP5K1B PIP5K1B PIK3CD PIK3CD PIK3CA PIK3CA LIMK1 LIMK1 RHOA RHOA FOS FOS NFKBIA NFKBIA IL1B IL1B ZAP70 ZAP70 AKT3 AKT3 MAPK1 MAPK1 CRKL CRKL PIK3R3 PIK3R3 FN1 FN1 IL2 IL2 RPS6KA3 RPS6KA3 ITGB1 ITGB1 ROCK2 ROCK2 NFKB1 NFKB1 CHUK CHUK LOC101364797 LOC101364797 MEFV MEFV GSK3B GSK3B NLRC4 NLRC4 FYB FYB TAB2 TAB2 CRK CRK MAP3K7 MAP3K7 RAC3 RAC3 BAIAP2 BAIAP2 PIK3R2 PIK3R2 MAP2K3 MAP2K3 ELMO2 ELMO2 VAV3 VAV3 PTK2 PTK2 IFNB1 IFNB1 MAP2K6 MAP2K6 ITGA5 ITGA5 LCK LCK NLRP3 NLRP3 ARF6 ARF6 ACTR3B ACTR3B PKN2 PKN2 WIPF1 WIPF1 IRAK1 IRAK1 TRAF6 TRAF6 ARHGEF7 ARHGEF7 MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 IRF3 IRF3 RAC2 RAC2 ACTR3 ACTR3 VAV2 VAV2 PTK2B PTK2B CDC42 CDC42 MAP2K7 MAP2K7 MYD88 MYD88 ARHGEF12 ARHGEF12 MAPK9 MAPK9 TRAF2 TRAF2 LOC101370467 LOC101370467 BCAR1 BCAR1 NFATC1 NFATC1 PIK3CB PIK3CB IL18 IL18 RPS6KA6 RPS6KA6 CD4 CD4 CD8B CD8B CD8A CD8A MAP2K1 MAP2K1 NFATC2 NFATC2 JUN JUN TNF TNF IKBKB IKBKB PIK3R1 PIK3R1 TLR4 TLR4 CCL2 CCL2 IL10 IL10 LOC101366544 LOC101366544 PIP5K1C PIP5K1C VAV1 VAV1 LAT LAT PKN1 PKN1 RPS6KA2 RPS6KA2 ARHGEF28 ARHGEF28 PIP5K1A PIP5K1A DOCK1 DOCK1 WASL WASL SRC SRC ARHGEF1 ARHGEF1 MAPK8 MAPK8 ROCK1 ROCK1 PLCG1 PLCG1 TBK1 TBK1 WIPF3 WIPF3 ELMO1 ELMO1 IKBKG IKBKG GIT2 GIT2 MAP2K4 MAP2K4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1072 aa)
RELATranscription factor p65. (539 aa)
ACTBActin, cytoplasmic 1 isoform X2. (375 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
WIPF2WAS/WASL-interacting protein family member 2. (440 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PXNPaxillin; Belongs to the paxillin family. (557 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
SKAP2Src kinase-associated phosphoprotein 2 isoform X1. (359 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
ZAP70Tyrosine-protein kinase ZAP-70; Belongs to the protein kinase superfamily. Tyr protein kinase family. (326 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKLCrk-like protein. (303 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
FN1Fibronectin isoform X1. (2476 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC101364797Uncharacterized protein LOC101364797. (416 aa)
MEFVPyrin. (850 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (889 aa)
FYBFYN-binding protein isoform X1. (837 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (522 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (732 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
IFNB1Interferon beta. (182 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1104 aa)
LCKTyrosine-protein kinase. (509 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1034 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (418 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
WIPF1WAS/WASL-interacting protein family member 1. (490 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform X1. (724 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (805 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRF3Interferon regulatory factor 3. (420 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ACTR3Actin-related protein 3 isoform X1; Belongs to the actin family. (418 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1524 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (503 aa)
LOC101370467Uncharacterized protein LOC101370467. (276 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (865 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (823 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
CD8BT-cell surface glycoprotein CD8 beta chain isoform X1. (210 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (920 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CCL2C-C motif chemokine. (101 aa)
IL10Interleukin-10. (178 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (661 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
LATLinker for activation of T-cells family member 1. (227 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (956 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform X1. (1688 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (582 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1889 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (519 aa)
SRCTyrosine-protein kinase. (553 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (974 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (782 aa)
WIPF3WAS/WASL-interacting protein family member 3. (1048 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (742 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
GIT2ARF GTPase-activating protein GIT2 isoform X1. (761 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (411 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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