STRINGSTRING
MAPK10 MAPK10 CXCL8 CXCL8 CFLAR CFLAR CASP8 CASP8 GNAI1 GNAI1 RELA RELA PLCB3 PLCB3 FADD FADD TLR2 TLR2 C1QA C1QA C1QC C1QC C1QB C1QB C3 C3 GNA15 GNA15 AKT1 AKT1 IRAK4 IRAK4 AKT2 AKT2 TGFB1 TGFB1 GNA14 GNA14 GNAQ GNAQ MAPK3 MAPK3 IL6 IL6 PIK3CD PIK3CD PIK3CA PIK3CA CALR CALR SERPINE1 SERPINE1 GNAI2 GNAI2 FOS FOS TGFB3 TGFB3 NOS2 NOS2 NFKBIA NFKBIA IL1B IL1B PLCB2 PLCB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 IL2 IL2 NFKB1 NFKB1 CHUK CHUK LOC101364797 LOC101364797 PIK3R2 PIK3R2 IL12B IL12B PPP2CA PPP2CA IFNB1 IFNB1 LOC101377413 LOC101377413 LOC101382544 LOC101382544 IL12A IL12A GNAI3 GNAI3 PPP2CB PPP2CB SMAD2 SMAD2 IRAK1 IRAK1 TRAF6 TRAF6 GNAL GNAL MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 IFNGR1 IFNGR1 MYD88 MYD88 FASLG FASLG LOC101371529 LOC101371529 LOC101370944 LOC101370944 LOC101371244 LOC101371244 MAPK9 MAPK9 PPP2R2A PPP2R2A PIK3CB PIK3CB KNG1 KNG1 TNFRSF1A TNFRSF1A GNAS GNAS LOC105757053 LOC105757053 PPP2R2B PPP2R2B CCL5 CCL5 PLCB1 PLCB1 JUN JUN CD3E CD3E CD3G CD3G CD3D CD3D TNF TNF TGFB2 TGFB2 IKBKB IKBKB PIK3R1 PIK3R1 TLR4 TLR4 IFNG IFNG TGFBR2 TGFBR2 BDKRB2 BDKRB2 CCL2 CCL2 PPP2R2C PPP2R2C IL10 IL10 LOC101367407 LOC101367407 GNA11 GNA11 TLR6 TLR6 TGFBR1 TGFBR1 PPP2R2D PPP2R2D CD247 CD247 MAPK8 MAPK8 ADCY1 ADCY1 FAS FAS LOC101370160 LOC101370160 LOC105758121 LOC105758121 PPP2R1B PPP2R1B IKBKG IKBKG PLCB4 PLCB4 PPP2R1A PPP2R1A MAP2K4 MAP2K4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
RELATranscription factor p65. (539 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (219 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
C1QBComplement C1q subcomponent subunit B. (249 aa)
C3Complement C3. (1661 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALRCalreticulin. (411 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC101364797Uncharacterized protein LOC101364797. (416 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
IFNB1Interferon beta. (182 aa)
LOC101377413Angiotensin-converting enzyme. (1312 aa)
LOC101382544Angiotensin-converting enzyme. (772 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform X1. (724 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (461 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (277 aa)
LOC101371529Regakine-1-like. (107 aa)
LOC101370944C-C motif chemokine. (93 aa)
LOC101371244C-C motif chemokine. (93 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
KNG1Kininogen-1 isoform X1. (622 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CCL5C-C motif chemokine. (146 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (190 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain isoform X1. (180 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
CCL2C-C motif chemokine. (101 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
IL10Interleukin-10. (178 aa)
LOC101367407Uncharacterized protein LOC101367407. (575 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (795 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (424 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (185 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
FASTumor necrosis factor receptor superfamily member 6. (319 aa)
LOC101370160Toll-like receptor 9 isoform X1. (1056 aa)
LOC105758121C-C motif chemokine 3-like. (137 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (694 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (411 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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