STRINGSTRING
MAPK10 MAPK10 RALGDS RALGDS AREG AREG CCND1 CCND1 RAC1 RAC1 BAD BAD GRB2 GRB2 MAP2K2 MAP2K2 GADD45B GADD45B APC2 APC2 AKT1 AKT1 RALA RALA AKT2 AKT2 TGFB1 TGFB1 ARAF ARAF MAPK3 MAPK3 CASP9 CASP9 LOC101386944 LOC101386944 PIK3CD PIK3CD RPS6KB1 RPS6KB1 BCL2 BCL2 PIK3CA PIK3CA TP53 TP53 TGFA TGFA RHOA RHOA FOS FOS TGFB3 TGFB3 DDB2 DDB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 BBC3 BBC3 APC APC AXIN1 AXIN1 MSH2 MSH2 MSH6 MSH6 GSK3B GSK3B HRAS HRAS RAC3 RAC3 PIK3R2 PIK3R2 RALB RALB MSH3 MSH3 AXIN2 AXIN2 APPL1 APPL1 BAK1 BAK1 SOS2 SOS2 SMAD2 SMAD2 GADD45G GADD45G SOS1 SOS1 SMAD4 SMAD4 RAC2 RAC2 MTOR MTOR MAPK9 MAPK9 PIK3CB PIK3CB POLK POLK MAP2K1 MAP2K1 SMAD3 SMAD3 JUN JUN GADD45A GADD45A BAX BAX LOC101367134 LOC101367134 TCF7L1 TCF7L1 DCC DCC TGFB2 TGFB2 PIK3R1 PIK3R1 BIRC5 BIRC5 TGFBR2 TGFBR2 PMAIP1 PMAIP1 CTNNB1 CTNNB1 LOC101366544 LOC101366544 RAF1 RAF1 TGFBR1 TGFBR1 NRAS NRAS LOC101386882 LOC101386882 EREG EREG MAPK8 MAPK8 CDKN1A CDKN1A MYC MYC EGF EGF LEF1 LEF1 CASP3 CASP3 MLH1 MLH1 TCF7L2 TCF7L2 BRAF BRAF EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (888 aa)
AREGAmphiregulin isoform X1. (253 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
APC2Adenomatous polyposis coli protein 2. (2267 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RALARas-related protein Ral-A. (206 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (451 aa)
LOC101386944Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
BBC3Bcl-2-binding component 3. (193 aa)
APCAdenomatous polyposis coli protein isoform X1. (2844 aa)
AXIN1Axin-1. (867 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1364 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
RALBRas-related protein Ral-B. (206 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1126 aa)
AXIN2Axin-2 isoform X1. (842 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (870 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
LOC101367134GTPase HRas-like. (177 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
DCCNetrin receptor DCC. (1214 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NRASGTPase NRas. (189 aa)
LOC101386882LOW QUALITY PROTEIN: cytochrome c, testis-specific-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
EREGProepiregulin isoform X1. (166 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (413 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (759 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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