STRINGSTRING
PAK1 PAK1 PAK2 PAK2 VHL VHL HGF HGF RAC1 RAC1 BAD BAD GRB2 GRB2 MAP2K2 MAP2K2 AKT1 AKT1 AKT2 AKT2 TGFB1 TGFB1 PAK4 PAK4 ARAF ARAF TFE3 TFE3 MAPK3 MAPK3 EP300 EP300 RBX1 RBX1 PIK3CD PIK3CD PIK3CA PIK3CA TGFA TGFA TGFB3 TGFB3 PAK3 PAK3 EGLN3 EGLN3 PAK6 PAK6 AKT3 AKT3 MAPK1 MAPK1 CRKL CRKL PIK3R3 PIK3R3 RAP1A RAP1A PRCC PRCC TCEB2 TCEB2 CREBBP CREBBP EPAS1 EPAS1 ARNT2 ARNT2 HRAS HRAS TCEB1 TCEB1 CRK CRK PIK3R2 PIK3R2 EGLN1 EGLN1 FLCN FLCN RAP1B RAP1B SLC2A1 SLC2A1 GAB1 GAB1 SOS2 SOS2 MET MET SOS1 SOS1 PTPN11 PTPN11 CDC42 CDC42 HIF1A HIF1A ETS1 ETS1 PIK3CB PIK3CB FH FH MAP2K1 MAP2K1 CUL2 CUL2 PAK7 PAK7 JUN JUN LOC101367134 LOC101367134 TGFB2 TGFB2 PIK3R1 PIK3R1 LOC101366544 LOC101366544 RAF1 RAF1 EGLN2 EGLN2 PDGFB PDGFB NRAS NRAS RAPGEF1 RAPGEF1 ARNT ARNT LOC101379527 LOC101379527 LOC101374328 LOC101374328 VEGFA VEGFA CDKN1A CDKN1A LOC101371328 LOC101371328 BRAF BRAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform X1. (219 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
TFE3Transcription factor E3 isoform X1. (571 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EP300Histone acetyltransferase p300. (2421 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X1. (116 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
EGLN3Egl nine homolog 3 isoform X1. (239 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKLCrk-like protein. (303 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
PRCCProline-rich protein PRCC. (491 aa)
TCEB2Transcription elongation factor B polypeptide 2. (118 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
EPAS1Endothelial PAS domain-containing protein 1. (868 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (706 aa)
HRASGTPase HRas isoform X1. (189 aa)
TCEB1Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
EGLN1Egl nine homolog 1. (428 aa)
FLCNFolliculin. (579 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
METHepatocyte growth factor receptor. (1382 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
ETS1Protein C-ets-1 isoform X1. (485 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
PAK7Serine/threonine-protein kinase PAK 7. (535 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
LOC101367134GTPase HRas-like. (177 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
EGLN2Egl nine homolog 2. (405 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
NRASGTPase NRas. (189 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
LOC101379527LOW QUALITY PROTEIN: cullin-2-like; Belongs to the cullin family. (738 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (587 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
LOC101371328LOW QUALITY PROTEIN: folliculin-like. (610 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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