STRINGSTRING
MAPK10 MAPK10 RALGDS RALGDS BCL2L1 BCL2L1 E2F1 E2F1 PLD1 PLD1 CCND1 CCND1 RELA RELA CDK6 CDK6 RAC1 RAC1 BAD BAD E2F2 E2F2 ERBB2 ERBB2 GADD45B GADD45B AKT1 AKT1 RALA RALA AKT2 AKT2 TGFB1 TGFB1 ARAF ARAF MAPK3 MAPK3 CASP9 CASP9 PIK3CD PIK3CD RPS6KB1 RPS6KB1 PIK3CA PIK3CA TP53 TP53 PLD2 PLD2 TGFA TGFA TGFB3 TGFB3 RB1 RB1 DDB2 DDB2 AKT3 AKT3 RAD51 RAD51 MAPK1 MAPK1 PIK3R3 PIK3R3 CDK4 CDK4 NFKB1 NFKB1 CHUK CHUK RAC3 RAC3 PIK3R2 PIK3R2 RALB RALB BRCA2 BRCA2 BAK1 BAK1 SMAD2 SMAD2 GADD45G GADD45G ARHGEF6 ARHGEF6 SMAD4 SMAD4 STAT3 STAT3 RAC2 RAC2 MTOR MTOR CDC42 CDC42 MAPK9 MAPK9 PIK3CB PIK3CB POLK POLK E2F3 E2F3 RALBP1 RALBP1 MAP2K1 MAP2K1 SMAD3 SMAD3 GADD45A GADD45A BAX BAX TGFB2 TGFB2 IKBKB IKBKB PIK3R1 PIK3R1 TGFBR2 TGFBR2 LOC101366544 LOC101366544 RAF1 RAF1 TGFBR1 TGFBR1 STAT1 STAT1 VEGFA VEGFA MAPK8 MAPK8 CDKN1A CDKN1A EGF EGF JAK1 JAK1 BRAF BRAF IKBKG IKBKG EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (888 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1Transcription factor E2F1. (431 aa)
PLD1Phospholipase. (1074 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65. (539 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
BADBcl2-associated agonist of cell death. (168 aa)
E2F2Transcription factor E2F2. (442 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RALARas-related protein Ral-A. (206 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (451 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PLD2Phospholipase. (933 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
RB1Retinoblastoma-associated protein. (936 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (340 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
RALBRas-related protein Ral-B. (206 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3150 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6 isoform X1. (775 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (870 aa)
E2F3Transcription factor E2F3 isoform X1. (468 aa)
RALBP1ralA-binding protein 1. (649 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (587 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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