STRINGSTRING
CDH1 CDH1 CCND1 CCND1 BAD BAD GRB2 GRB2 ERBB2 ERBB2 MAP2K2 MAP2K2 GADD45B GADD45B APC2 APC2 AKT1 AKT1 AKT2 AKT2 ARAF ARAF ELK1 ELK1 MAPK3 MAPK3 CASP9 CASP9 PIK3CD PIK3CD PIK3CA PIK3CA TP53 TP53 DDB2 DDB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 APC APC AXIN1 AXIN1 PDPK1 PDPK1 GSK3B GSK3B HRAS HRAS PIK3R2 PIK3R2 AXIN2 AXIN2 LOC101376741 LOC101376741 BAK1 BAK1 SOS2 SOS2 PTEN PTEN GADD45G GADD45G SOS1 SOS1 PIK3CB PIK3CB ILK ILK POLK POLK MAP2K1 MAP2K1 GADD45A GADD45A BAX BAX LOC101367134 LOC101367134 TCF7L1 TCF7L1 PIK3R1 PIK3R1 CTNNB1 CTNNB1 RAF1 RAF1 CTNNA1 CTNNA1 NRAS NRAS LOC101375473 LOC101375473 CDKN1A CDKN1A MYC MYC EGF EGF CTNNA2 CTNNA2 LEF1 LEF1 MLH1 MLH1 TCF7L2 TCF7L2 BRAF BRAF EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
APC2Adenomatous polyposis coli protein 2. (2267 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (451 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
APCAdenomatous polyposis coli protein isoform X1. (2844 aa)
AXIN1Axin-1. (867 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
AXIN2Axin-2 isoform X1. (842 aa)
LOC101376741Forkhead box protein O3. (453 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
POLKDNA polymerase kappa. (870 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
LOC101367134GTPase HRas-like. (177 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
CTNNA1Catenin alpha-1 isoform X1. (929 aa)
NRASGTPase NRas. (189 aa)
LOC101375473LOW QUALITY PROTEIN: uncharacterized protein LOC101375473. (703 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
CTNNA2Catenin alpha-2 isoform X1. (953 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (413 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (759 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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