STRINGSTRING
PLCG2 PLCG2 E2F1 E2F1 CCND1 CCND1 CDK6 CDK6 GRB2 GRB2 CALM1 CALM1 E2F2 E2F2 MAP2K2 MAP2K2 GADD45B GADD45B SHC2 SHC2 AKT1 AKT1 AKT2 AKT2 SHC4 SHC4 ARAF ARAF MAPK3 MAPK3 PIK3CD PIK3CD PIK3CA PIK3CA TP53 TP53 TGFA TGFA PRKCB PRKCB RB1 RB1 DDB2 DDB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 CALM3 CALM3 LOC101373722 LOC101373722 CAMK4 CAMK4 LOC101372085 LOC101372085 CDK4 CDK4 PDGFRB PDGFRB CAMK2A CAMK2A CALM2 CALM2 HRAS HRAS PIK3R2 PIK3R2 MDM2 MDM2 CAMK2D CAMK2D CALML6 CALML6 BAK1 BAK1 SOS2 SOS2 CAMK1G CAMK1G CAMK1D CAMK1D PRKCG PRKCG PTEN PTEN GADD45G GADD45G SHC3 SHC3 SOS1 SOS1 MTOR MTOR CALML3 CALML3 CALML4 CALML4 IGF1 IGF1 PIK3CB PIK3CB POLK POLK E2F3 E2F3 CAMK2B CAMK2B PDGFA PDGFA MAP2K1 MAP2K1 GADD45A GADD45A BAX BAX LOC101367134 LOC101367134 PRKCA PRKCA PIK3R1 PIK3R1 RAF1 RAF1 PDGFRA PDGFRA PDGFB PDGFB NRAS NRAS SHC1 SHC1 LOC101386691 LOC101386691 CAMK1 CAMK1 IGF1R IGF1R CDKN1A CDKN1A EGF EGF CALML5 CALML5 PLCG1 PLCG1 BRAF BRAF EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
E2F1Transcription factor E2F1. (431 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
E2F2Transcription factor E2F2. (442 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
SHC2SHC-transforming protein 2. (586 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SHC4SHC-transforming protein 4. (630 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
RB1Retinoblastoma-associated protein. (936 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (340 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (477 aa)
CALML6Calmodulin-like protein 6. (167 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (470 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D; Belongs to the protein kinase superfamily. (385 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SHC3SHC-transforming protein 3. (587 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (870 aa)
E2F3Transcription factor E2F3 isoform X1. (468 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
LOC101367134GTPase HRas-like. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
NRASGTPase NRas. (189 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1 isoform X2; Belongs to the protein kinase superfamily. (409 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.