STRINGSTRING
FGF18 FGF18 E2F1 E2F1 CDH1 CDH1 HGF HGF CCND1 CCND1 FGF4 FGF4 FGF3 FGF3 CDK6 CDK6 BAD BAD PDGFC PDGFC FGFR1 FGFR1 E2F2 E2F2 MAP2K2 MAP2K2 GADD45B GADD45B FGF22 FGF22 AKT1 AKT1 AKT2 AKT2 ARAF ARAF MAPK3 MAPK3 PIK3CD PIK3CD FGF1 FGF1 PIK3CA PIK3CA TP53 TP53 RB1 RB1 DDB2 DDB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 FGF9 FGF9 CDK4 CDK4 FGF8 FGF8 FGF17 FGF17 PDGFRB PDGFRB HRAS HRAS PIK3R2 PIK3R2 MDM2 MDM2 FGF5 FGF5 BAK1 BAK1 MET MET FGF20 FGF20 PTEN PTEN GADD45G GADD45G IGF1 IGF1 PIK3CB PIK3CB POLK POLK E2F3 E2F3 PDGFA PDGFA MAP2K1 MAP2K1 FGF21 FGF21 FGF16 FGF16 GADD45A GADD45A BAX BAX LOC101367134 LOC101367134 FGF10 FGF10 FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 PDGFD PDGFD RAF1 RAF1 PDGFRA PDGFRA FGF7 FGF7 PDGFB PDGFB NRAS NRAS FGF2 FGF2 MITF MITF IGF1R IGF1R CDKN1A CDKN1A EGF EGF BRAF BRAF FGF19 FGF19 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
E2F1Transcription factor E2F1. (431 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
BADBcl2-associated agonist of cell death. (168 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
E2F2Transcription factor E2F2. (442 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RB1Retinoblastoma-associated protein. (936 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (340 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
METHepatocyte growth factor receptor. (1382 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (870 aa)
E2F3Transcription factor E2F3 isoform X1. (468 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
LOC101367134GTPase HRas-like. (177 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PDGFDPlatelet-derived growth factor D. (328 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
NRASGTPase NRas. (189 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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