STRINGSTRING
CCND1 CCND1 RELA RELA BAD BAD GRB2 GRB2 EIF4EBP1 EIF4EBP1 RARA RARA MAP2K2 MAP2K2 AKT1 AKT1 AKT2 AKT2 ARAF ARAF PIM2 PIM2 MAPK3 MAPK3 PIK3CD PIK3CD MPO MPO CD14 CD14 RPS6KB1 RPS6KB1 PIK3CA PIK3CA CCNA1 CCNA1 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 CCNA2 CCNA2 NFKB1 NFKB1 CHUK CHUK CEBPE CEBPE CSF1R CSF1R BCL2A1 BCL2A1 HRAS HRAS LOC101381082 LOC101381082 PIK3R2 PIK3R2 CEBPA CEBPA PPARD PPARD PML PML SOS2 SOS2 CSF2 CSF2 PIM1 PIM1 SOS1 SOS1 PER2 PER2 JUP JUP STAT5A STAT5A STAT3 STAT3 MTOR MTOR PIK3CB PIK3CB RUNX1T1 RUNX1T1 MAP2K1 MAP2K1 FLT3 FLT3 DUSP6 DUSP6 LOC101367134 LOC101367134 TCF7L1 TCF7L1 IKBKB IKBKB PIK3R1 PIK3R1 ZBTB16 ZBTB16 RAF1 RAF1 KIT KIT SPI1 SPI1 NRAS NRAS RUNX1 RUNX1 MYC MYC STAT5B STAT5B LEF1 LEF1 TCF7L2 TCF7L2 BRAF BRAF IKBKG IKBKG ITGAM ITGAM RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65. (539 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MPOMyeloperoxidase isoform X1. (719 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
CCNA2cyclin-A2 isoform X1; Belongs to the cyclin family. (433 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
BCL2A1Bcl-2-related protein A1. (174 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC101381082High affinity immunoglobulin gamma Fc receptor I. (350 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CEBPACCAAT/enhancer-binding protein alpha. (354 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
PMLProtein PML. (928 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PER2Period circadian protein homolog 2. (1265 aa)
JUPJunction plakoglobin. (744 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
RUNX1T1Protein CBFA2T1 isoform X1. (604 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC101367134GTPase HRas-like. (177 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (982 aa)
SPI1Transcription factor PU.1 isoform X1. (271 aa)
NRASGTPase NRas. (189 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (413 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1114 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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