STRINGSTRING
ITGAV ITGAV LAMC3 LAMC3 BCL2L1 BCL2L1 E2F1 E2F1 CCND1 CCND1 RELA RELA CDK6 CDK6 E2F2 E2F2 ITGA3 ITGA3 GADD45B GADD45B TRAF3 TRAF3 AKT1 AKT1 AKT2 AKT2 LAMC2 LAMC2 LAMC1 LAMC1 CASP9 CASP9 LOC101386944 LOC101386944 PIK3CD PIK3CD LOC101369714 LOC101369714 BCL2 BCL2 PIK3CA PIK3CA TP53 TP53 LAMB2 LAMB2 RB1 RB1 DDB2 DDB2 NOS2 NOS2 COL4A5 COL4A5 TRAF4 TRAF4 NFKBIA NFKBIA XIAP XIAP AKT3 AKT3 PIK3R3 PIK3R3 FN1 FN1 CDK4 CDK4 ITGB1 ITGB1 NFKB1 NFKB1 CHUK CHUK CKS1B CKS1B APAF1 APAF1 SKP2 SKP2 PIK3R2 PIK3R2 PTK2 PTK2 PTGS2 PTGS2 ITGA2B ITGA2B ITGA6 ITGA6 BAK1 BAK1 RXRG RXRG LAMB3 LAMB3 MAX MAX TRAF6 TRAF6 COL4A1 COL4A1 PTEN PTEN COL4A3 COL4A3 COL4A4 COL4A4 GADD45G GADD45G CKS2 CKS2 BIRC7 BIRC7 CCNE2 CCNE2 ITGA2 ITGA2 CDKN1B CDKN1B LAMB4 LAMB4 TRAF2 TRAF2 PIK3CB PIK3CB POLK POLK E2F3 E2F3 GADD45A GADD45A BAX BAX IKBKB IKBKB PIK3R1 PIK3R1 BIRC2 BIRC2 BIRC3 BIRC3 TRAF5 TRAF5 CCNE1 CCNE1 ZBTB17 ZBTB17 LOC101386882 LOC101386882 LAMA1 LAMA1 LAMA5 LAMA5 COL4A2 COL4A2 CDKN1A CDKN1A MYC MYC RXRA RXRA TRAF1 TRAF1 FHIT FHIT LAMB1 LAMB1 CASP3 CASP3 LAMA2 LAMA2 LAMA3 LAMA3 COL4A6 COL4A6 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1053 aa)
LAMC3Laminin subunit gamma-3. (1578 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1Transcription factor E2F1. (431 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65. (539 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
E2F2Transcription factor E2F2. (442 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1065 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMC2Laminin subunit gamma-2. (1192 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (451 aa)
LOC101386944Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC101369714Laminin subunit alpha-4. (1451 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LAMB2Laminin subunit beta-2. (1805 aa)
RB1Retinoblastoma-associated protein. (936 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
COL4A5Collagen alpha-5(IV) chain. (1673 aa)
TRAF4TNF receptor-associated factor. (470 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
FN1Fibronectin isoform X1. (2476 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (340 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
ITGA2BIntegrin alpha-IIb isoform X1; Belongs to the integrin alpha chain family. (1036 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1130 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
MAXProtein max isoform X1. (190 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
COL4A1Collagen alpha-1(IV) chain. (1669 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (430 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LAMB4Laminin subunit beta-4. (1747 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (503 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (870 aa)
E2F3Transcription factor E2F3 isoform X1. (468 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (619 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform X1. (799 aa)
LOC101386882LOW QUALITY PROTEIN: cytochrome c, testis-specific-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMA1Laminin subunit alpha-1. (3085 aa)
LAMA5Laminin subunit alpha-5. (3386 aa)
COL4A2Collagen alpha-2(IV) chain. (1762 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (497 aa)
TRAF1TNF receptor-associated factor. (415 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
LAMB1Laminin subunit beta-1 isoform X1. (1831 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
LAMA2Laminin subunit alpha-2. (3203 aa)
LAMA3Laminin subunit alpha-3. (3311 aa)
COL4A6Collagen alpha-6(IV) chain. (1685 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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