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PDHA2 PDHA2 SLC7A5 SLC7A5 GLS GLS SLC2A2 SLC2A2 HKDC1 HKDC1 FGFR1 FGFR1 ERBB2 ERBB2 MAP2K2 MAP2K2 SIRT6 SIRT6 AKT1 AKT1 PFKM PFKM FGFR3 FGFR3 AKT2 AKT2 MAPK3 MAPK3 PIK3CD PIK3CD IDH2 IDH2 NTRK3 NTRK3 PIK3CA PIK3CA TP53 TP53 HK2 HK2 LOC101364991 LOC101364991 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 SLC1A5 SLC1A5 HK3 HK3 PDHA1 PDHA1 GLS2 GLS2 PDGFRB PDGFRB NTRK1 NTRK1 SIRT3 SIRT3 HRAS HRAS PIK3R2 PIK3R2 LDHB LDHB SLC2A1 SLC2A1 LOC101367475 LOC101367475 PDK1 PDK1 MET MET PFKP PFKP PGAM1 PGAM1 LOC101379659 LOC101379659 PTEN PTEN LOC101373853 LOC101373853 PFKL PFKL MTOR MTOR HIF1A HIF1A PDHB PDHB LOC101364543 LOC101364543 PIK3CB PIK3CB LOC101376002 LOC101376002 PGAM2 PGAM2 MAP2K1 MAP2K1 FLT3 FLT3 PKM PKM LOC101367134 LOC101367134 LOC101363101 LOC101363101 LDHC LDHC LDHAL6A LDHAL6A LOC101375731 LOC101375731 PIK3R1 PIK3R1 TIGAR TIGAR RAF1 RAF1 PDGFRA PDGFRA KIT KIT NRAS NRAS LOC101375376 LOC101375376 FGFR2 FGFR2 SLC16A3 SLC16A3 LOC101372299 LOC101372299 IDH1 IDH1 LOC101376828 LOC101376828 RET RET MYC MYC HK1 HK1 GCK GCK G6PD G6PD EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (506 aa)
GLSGlutaminase kidney isoform, mitochondrial isoform X1. (678 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
NTRK3Tyrosine-protein kinase receptor. (838 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
HK2Hexokinase-2. (917 aa)
LOC101364991L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
SLC1A5Amino acid transporter. (541 aa)
HK3Hexokinase-3. (924 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
GLS2Glutaminase liver isoform, mitochondrial isoform X1. (602 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (388 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
LOC101367475L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (340 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
METHepatocyte growth factor receptor. (1382 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (790 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
LOC101379659Protein SCO2 homolog, mitochondrial. (266 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC101373853L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (346 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
LOC101364543L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC101376002L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (332 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (590 aa)
LOC101367134GTPase HRas-like. (177 aa)
LOC101363101L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LDHAL6ALOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6A; Belongs to the LDH/MDH superfamily. (330 aa)
LOC101375731L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (362 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (982 aa)
NRASGTPase NRas. (189 aa)
LOC101375376L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SLC16A3Monocarboxylate transporter 4. (459 aa)
LOC101372299L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
LOC101376828L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (311 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1103 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
HK1Hexokinase-1 isoform X1. (935 aa)
GCKPhosphotransferase. (458 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (555 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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