STRINGSTRING
MAPK10 MAPK10 PCYT1A PCYT1A RALGDS RALGDS PLD1 PLD1 RAC1 RAC1 CHKA CHKA PDGFC PDGFC GRB2 GRB2 EIF4EBP1 EIF4EBP1 WASF2 WASF2 MAP2K2 MAP2K2 PPAP2C PPAP2C AKT1 AKT1 DGKD DGKD DGKQ DGKQ AKT2 AKT2 WAS WAS DGKK DGKK MAPK3 MAPK3 PIP5K1B PIP5K1B PIK3CD PIK3CD RPS6KB1 RPS6KB1 GPCPD1 GPCPD1 PIK3CA PIK3CA PLD2 PLD2 PRKCB PRKCB SLC44A2 SLC44A2 FOS FOS DGKB DGKB PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 SLC22A1 SLC22A1 SLC22A2 SLC22A2 SLC22A3 SLC22A3 PDGFRB PDGFRB TSC2 TSC2 PDPK1 PDPK1 HRAS HRAS RAC3 RAC3 PIK3R2 PIK3R2 DGKE DGKE SP1 SP1 WASF1 WASF1 SOS2 SOS2 SLC22A4 SLC22A4 SLC22A5 SLC22A5 RHEB RHEB PRKCG PRKCG CHKB CHKB SLC44A1 SLC44A1 SOS1 SOS1 LYPLA1 LYPLA1 RAC2 RAC2 MTOR MTOR HIF1A HIF1A MAPK9 MAPK9 PIK3CB PIK3CB DGKG DGKG PDGFA PDGFA MAP2K1 MAP2K1 PPAP2B PPAP2B WASF3 WASF3 JUN JUN SLC44A4 SLC44A4 LOC101367134 LOC101367134 PRKCA PRKCA PIK3R1 PIK3R1 PPAP2A PPAP2A DGKI DGKI SLC5A7 SLC5A7 PCYT1B PCYT1B CHPT1 CHPT1 PDGFD PDGFD LOC101366544 LOC101366544 PIP5K1C PIP5K1C RAF1 RAF1 PDGFRA PDGFRA PDGFB PDGFB DGKZ DGKZ LOC101378552 LOC101378552 PLA2G4B PLA2G4B NRAS NRAS TSC1 TSC1 SLC44A3 SLC44A3 DGKA DGKA PIP5K1A PIP5K1A PLA2G4A PLA2G4A DGKH DGKH MAPK8 MAPK8 SLC44A5 SLC44A5 EGF EGF PLCG1 PLCG1 EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
PCYT1ACholine-phosphate cytidylyltransferase A. (367 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (888 aa)
PLD1Phospholipase. (1074 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
CHKACholine kinase alpha. (413 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PPAP2CLipid phosphate phosphohydrolase 2. (288 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
DGKDDiacylglycerol kinase. (1214 aa)
DGKQDiacylglycerol kinase. (946 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
DGKKDiacylglycerol kinase. (1262 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GPCPD1. (673 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD2Phospholipase. (933 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC44A2Choline transporter-like protein 2 isoform X1; Belongs to the CTL (choline transporter-like) family. (711 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
DGKBDiacylglycerol kinase. (803 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
SLC22A2Solute carrier family 22 member 2. (554 aa)
SLC22A3Solute carrier family 22 member 3. (550 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
TSC2Tuberin isoform X1. (1813 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
DGKEDiacylglycerol kinase. (572 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
SLC22A4Solute carrier family 22 member 4 isoform X1. (553 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
RHEBGTP-binding protein Rheb isoform X1. (184 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CHKBCholine/ethanolamine kinase. (435 aa)
SLC44A1Choline transporter-like protein 1 isoform X1; Belongs to the CTL (choline transporter-like) family. (652 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
LYPLA1Acyl-protein thioesterase 1 isoform X1. (230 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
DGKGDiacylglycerol kinase. (790 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PPAP2BLipid phosphate phosphohydrolase 3. (312 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (467 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
SLC44A4Choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (710 aa)
LOC101367134GTPase HRas-like. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PPAP2ALipid phosphate phosphohydrolase 1 isoform X1. (286 aa)
DGKIDiacylglycerol kinase. (1071 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
PCYT1BCholine-phosphate cytidylyltransferase B. (302 aa)
CHPT1Cholinephosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa)
PDGFDPlatelet-derived growth factor D. (328 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (661 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
DGKZDiacylglycerol kinase. (1114 aa)
LOC101378552Acyl-protein thioesterase 1-like isoform X1. (230 aa)
PLA2G4BPhospholipase A2. (782 aa)
NRASGTPase NRas. (189 aa)
TSC1Hamartin isoform X1. (1168 aa)
SLC44A3Choline transporter-like protein 3 isoform X1; Belongs to the CTL (choline transporter-like) family. (652 aa)
DGKADiacylglycerol kinase. (807 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (582 aa)
PLA2G4APhospholipase A2. (749 aa)
DGKHDiacylglycerol kinase. (1221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SLC44A5Choline transporter-like protein 5; Belongs to the CTL (choline transporter-like) family. (726 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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