STRINGSTRING
PPP3CA PPP3CA CSNK2A1 CSNK2A1 NFATC3 NFATC3 RELA RELA BATF2 BATF2 TLR2 TLR2 ALK ALK MAP2K2 MAP2K2 AKT1 AKT1 CSNK2A2 CSNK2A2 AKT2 AKT2 MAPK3 MAPK3 PIK3CD PIK3CD PPP3R1 PPP3R1 RPS6KB1 RPS6KB1 PRKCQ PRKCQ PIK3CA PIK3CA FOS FOS BATF BATF NFKBIA NFKBIA ZAP70 ZAP70 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 NFKB1 NFKB1 CHUK CHUK LOC101364797 LOC101364797 HRAS HRAS PIK3R2 PIK3R2 MAP2K3 MAP2K3 MAP2K6 MAP2K6 MAP3K3 MAP3K3 LCK LCK CD28 CD28 JAK2 JAK2 NFKBIE NFKBIE TIRAP TIRAP TRAF6 TRAF6 MAPK11 MAPK11 MAPK12 MAPK12 RASGRP1 RASGRP1 PTEN PTEN MAPK13 MAPK13 MAPK14 MAPK14 IFNGR1 IFNGR1 PTPN11 PTPN11 STAT3 STAT3 MTOR MTOR HIF1A HIF1A MYD88 MYD88 PDCD1 PDCD1 NFATC1 NFATC1 PIK3CB PIK3CB PTPN6 PTPN6 CD4 CD4 PPP3R2 PPP3R2 BATF3 BATF3 MAP2K1 MAP2K1 NFATC2 NFATC2 JUN JUN CD3E CD3E CD3G CD3G CD3D CD3D CSNK2B CSNK2B LOC101367134 LOC101367134 IKBKB IKBKB PIK3R1 PIK3R1 TLR4 TLR4 IFNG IFNG LOC101367407 LOC101367407 RAF1 RAF1 NFKBIB NFKBIB LAT LAT EML4 EML4 NRAS NRAS STAT1 STAT1 PPP3CC PPP3CC TICAM2 TICAM2 PPP3CB PPP3CB LOC101374328 LOC101374328 CD274 CD274 CD247 CD247 EGF EGF LOC101370160 LOC101370160 JAK1 JAK1 PLCG1 PLCG1 IKBKG IKBKG EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CSNK2A1Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (391 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1072 aa)
RELATranscription factor p65. (539 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
ALKTyrosine-protein kinase receptor. (1196 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
ZAP70Tyrosine-protein kinase ZAP-70; Belongs to the protein kinase superfamily. Tyr protein kinase family. (326 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC101364797Uncharacterized protein LOC101364797. (416 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
LCKTyrosine-protein kinase. (509 aa)
CD28T-cell-specific surface glycoprotein CD28. (221 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (221 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PDCD1Programmed cell death protein 1. (288 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (823 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3 isoform X1. (125 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (920 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (190 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain isoform X1. (180 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
LOC101367134GTPase HRas-like. (177 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC101367407Uncharacterized protein LOC101367407. (575 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X1. (359 aa)
LATLinker for activation of T-cells family member 1. (227 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X1. (986 aa)
NRASGTPase NRas. (189 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
TICAM2TIR domain-containing adapter molecule 2. (233 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
CD274Programmed cell death 1 ligand 1. (290 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (185 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
LOC101370160Toll-like receptor 9 isoform X1. (1056 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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