(71 nodes) Leukemia cell line network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLEKHH2	Pleckstrin homology domain-containing family H member 2. (1493 aa)
	ZFP42	Zinc finger protein 42 homolog. (312 aa)
	DNAJC24	dnaJ homolog subfamily C member 24. (149 aa)
	CACNG5	Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
	AFF1	AF4/FMR2 family member 1-like. (395 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	MGEA5	Bifunctional protein NCOAT. (539 aa)
	SAV1	Protein salvador homolog 1. (384 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
	CNTN6	Contactin-6-like. (1028 aa)
	HBM	Hemoglobin subunit mu; Belongs to the globin family. (141 aa)
	KLRK1	NKG2-D type II integral membrane protein. (216 aa)
	ILK	Integrin-linked protein kinase isoform X1. (452 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	PIK3IP1	Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (268 aa)
	RBL1	Retinoblastoma-like protein 1. (1068 aa)
	MAP2K7	Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
	FAM20B	Glycosaminoglycan xylosylkinase. (428 aa)
	FIP1L1	pre-mRNA 3'-end-processing factor FIP1 isoform X1. (594 aa)
	SERINC3	Serine incorporator 3. (473 aa)
	SLC22A5	Solute carrier family 22 member 5. (557 aa)
	NUDT4	Diphosphoinositol polyphosphate phosphohydrolase 2 isoform X1. (181 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (166 aa)
	LATS1	Serine/threonine-protein kinase LATS1. (1127 aa)
	LOC102728321	High affinity nerve growth factor receptor-like. (109 aa)
	PTK7	Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
	UBP1	Upstream-binding protein 1 isoform X2. (503 aa)
	FGFR1OP2	FGFR1 oncogene partner 2 homolog isoform X1. (253 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1. (114 aa)
	NUDT14	Uridine diphosphate glucose pyrophosphatase isoform X1. (186 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1. (508 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC102749767	Integrin alpha-IIb-like. (534 aa)
	BANF1	Barrier-to-autointegration factor isoform X1. (89 aa)
	DOCK10	Dedicator of cytokinesis protein 10 isoform X1; Belongs to the DOCK family. (1177 aa)
	LOC102746402	L-gulonolactone oxidase-like. (263 aa)
	LOC102739404	Integrin alpha-9-like. (152 aa)
	ITGA9	Integrin alpha-9-like. (470 aa)
	CST7	cystatin-F. (153 aa)
	YY1	Transcriptional repressor protein YY1. (410 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	MLN	Promotilin. (116 aa)
	IZUMO4	Izumo sperm-egg fusion protein 4 isoform X1. (218 aa)
	GOLGA1	Golgin subfamily A member 1. (765 aa)
	LOC102743429	Leucine-rich repeat-containing protein LOC400891-like. (392 aa)
	APEH	Acylamino-acid-releasing enzyme. (732 aa)
	THAP7	THAP domain-containing protein 7. (313 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	LOC102741220	Integrin alpha-9-like. (114 aa)
	BRD9	Bromodomain-containing protein 9. (109 aa)
	TOM1	Target of Myb protein 1; Belongs to the TOM1 family. (492 aa)
	LOC102741322	E3 ubiquitin-protein ligase MARCH4-like. (227 aa)
	RARA	Retinoic acid receptor alpha isoform X1. (462 aa)
	FLT3	Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (209 aa)
	LOC102734525	Sodium-coupled neutral amino acid transporter 4-like. (547 aa)
	BANF2	Barrier-to-autointegration factor-like protein. (90 aa)
	ALG14	UDP-N-acetylglucosamine transferase subunit ALG14 homolog. (216 aa)
	NTRK1	Tyrosine-protein kinase receptor. (592 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (271 aa)
	LOC102735245	Dedicator of cytokinesis protein 10-like; Belongs to the DOCK family. (227 aa)
	LOC102740348	Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
	IL3	Interleukin-3. (143 aa)
	LOC102729819	Protein CBFA2T1-like. (287 aa)
	LOC102747458	Hemoglobin subunit zeta-like; Belongs to the globin family. (142 aa)
	LOC102744110	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
	LOC102741057	Four-jointed box protein 1-like. (288 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	AFF1	A0A2U3YZ15	A0A2U3XE99	Tyrosine-protein kinase ABL1-like.	AF4/FMR2 family member 1-like.	0.454
ABL1	FLT3	A0A2U3YZ15	A0A2U3YRP4	Tyrosine-protein kinase ABL1-like.	Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.476
ABL1	LOC102728321	A0A2U3YZ15	A0A2U3XZA5	Tyrosine-protein kinase ABL1-like.	High affinity nerve growth factor receptor-like.	0.804
ABL1	NTRK1	A0A2U3YZ15	A0A2U3YYL0	Tyrosine-protein kinase ABL1-like.	Tyrosine-protein kinase receptor.	0.804
ABL1	RBL1	A0A2U3YZ15	A0A2U3XQM1	Tyrosine-protein kinase ABL1-like.	Retinoblastoma-like protein 1.	0.694
AFF1	ABL1	A0A2U3XE99	A0A2U3YZ15	AF4/FMR2 family member 1-like.	Tyrosine-protein kinase ABL1-like.	0.454
AFF1	POLR2H	A0A2U3XE99	A0A2U3Y3K2	AF4/FMR2 family member 1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1.	0.578
AGXT2	DLAT	A0A2U3XVW0	A0A2U3XPF8	Alanine--glyoxylate aminotransferase 2, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.530
BANF1	BRD9	A0A2U3Y943	A0A2U3YNB5	Barrier-to-autointegration factor isoform X1.	Bromodomain-containing protein 9.	0.491
BRD9	BANF1	A0A2U3YNB5	A0A2U3Y943	Bromodomain-containing protein 9.	Barrier-to-autointegration factor isoform X1.	0.491
CD247	CD28	A0A2U3XW81	A0A2U3YTM8	T-cell surface glycoprotein CD3 zeta chain.	T-cell-specific surface glycoprotein CD28.	0.519
CD247	CD4	A0A2U3XW81	A0A2U3Y2Q1	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD4.	0.726
CD247	KLRK1	A0A2U3XW81	A0A2U3XL39	T-cell surface glycoprotein CD3 zeta chain.	NKG2-D type II integral membrane protein.	0.483
CD247	POLR2H	A0A2U3XW81	A0A2U3Y3K2	T-cell surface glycoprotein CD3 zeta chain.	DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1.	0.441
CD247	PTK7	A0A2U3XW81	A0A2U3XZD5	T-cell surface glycoprotein CD3 zeta chain.	Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.612
CD28	CD247	A0A2U3YTM8	A0A2U3XW81	T-cell-specific surface glycoprotein CD28.	T-cell surface glycoprotein CD3 zeta chain.	0.519
CD28	CD4	A0A2U3YTM8	A0A2U3Y2Q1	T-cell-specific surface glycoprotein CD28.	T-cell surface glycoprotein CD4.	0.635
CD28	PTK7	A0A2U3YTM8	A0A2U3XZD5	T-cell-specific surface glycoprotein CD28.	Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.545
CD4	CD247	A0A2U3Y2Q1	A0A2U3XW81	T-cell surface glycoprotein CD4.	T-cell surface glycoprotein CD3 zeta chain.	0.726
CD4	CD28	A0A2U3Y2Q1	A0A2U3YTM8	T-cell surface glycoprotein CD4.	T-cell-specific surface glycoprotein CD28.	0.635