(18 nodes) Vascular endothelial cell network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102741463	Vascular cell adhesion protein 1-like. (318 aa)
	VCAM1	Vascular cell adhesion protein 1. (377 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	ATF7	Cyclic AMP-dependent transcription factor ATF-7 isoform X2. (483 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
	TJP1	Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1770 aa)
	LOC102732051	Prolyl 4-hydroxylase subunit alpha-3-like. (196 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
	VWF	Von Willebrand factor. (2285 aa)
	FAM124B	Protein FAM124B. (459 aa)
	THBD	Thrombomodulin. (577 aa)
	HHIP	Hedgehog-interacting protein-like. (662 aa)
	TNS4	Tensin-4. (711 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)
	DGKE	Diacylglycerol kinase. (514 aa)
	ECSCR	Endothelial cell-specific chemotaxis regulator. (213 aa)
	LOC102745316	Von Willebrand factor-like. (532 aa)
	LOC102742054	Ubiquitin thioesterase ZRANB1-like. (329 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN5	ICAM1	A0A2U3Z8Q2	A0A2U3YSH4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Intercellular adhesion molecule 1.	0.540
CLDN5	LOC102745316	A0A2U3Z8Q2	A0A2U3Z2D9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Von Willebrand factor-like.	0.806
CLDN5	TJP1	A0A2U3Z8Q2	A0A2U3XF36	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family.	0.964
CLDN5	VCAM1	A0A2U3Z8Q2	A0A2U3XA76	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Vascular cell adhesion protein 1.	0.473
CLDN5	VWF	A0A2U3Z8Q2	A0A2U3XX42	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Von Willebrand factor.	0.806
CSDE1	ICAM1	A0A2U3XB03	A0A2U3YSH4	Cold shock domain-containing protein E1 isoform X1.	Intercellular adhesion molecule 1.	0.452
DGKE	THBD	A0A2U3YXK6	A0A2U3YBW2	Diacylglycerol kinase.	Thrombomodulin.	0.772
ICAM1	CLDN5	A0A2U3YSH4	A0A2U3Z8Q2	Intercellular adhesion molecule 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.540
ICAM1	CSDE1	A0A2U3YSH4	A0A2U3XB03	Intercellular adhesion molecule 1.	Cold shock domain-containing protein E1 isoform X1.	0.452
ICAM1	LOC102745316	A0A2U3YSH4	A0A2U3Z2D9	Intercellular adhesion molecule 1.	Von Willebrand factor-like.	0.539
ICAM1	THBD	A0A2U3YSH4	A0A2U3YBW2	Intercellular adhesion molecule 1.	Thrombomodulin.	0.538
ICAM1	VCAM1	A0A2U3YSH4	A0A2U3XA76	Intercellular adhesion molecule 1.	Vascular cell adhesion protein 1.	0.784
ICAM1	VWF	A0A2U3YSH4	A0A2U3XX42	Intercellular adhesion molecule 1.	Von Willebrand factor.	0.639
LOC102745316	CLDN5	A0A2U3Z2D9	A0A2U3Z8Q2	Von Willebrand factor-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.806
LOC102745316	ICAM1	A0A2U3Z2D9	A0A2U3YSH4	Von Willebrand factor-like.	Intercellular adhesion molecule 1.	0.539
LOC102745316	THBD	A0A2U3Z2D9	A0A2U3YBW2	Von Willebrand factor-like.	Thrombomodulin.	0.551
LOC102745316	VCAM1	A0A2U3Z2D9	A0A2U3XA76	Von Willebrand factor-like.	Vascular cell adhesion protein 1.	0.479
LOC102745316	VWF	A0A2U3Z2D9	A0A2U3XX42	Von Willebrand factor-like.	Von Willebrand factor.	0.951
THBD	DGKE	A0A2U3YBW2	A0A2U3YXK6	Thrombomodulin.	Diacylglycerol kinase.	0.772
THBD	ICAM1	A0A2U3YBW2	A0A2U3YSH4	Thrombomodulin.	Intercellular adhesion molecule 1.	0.538