STRINGSTRING
RPS6KA6 RPS6KA6 LRRK2 LRRK2 ATF7 ATF7 TFEB TFEB FOXO3 FOXO3 MAPK10 MAPK10 MAP2K1 MAP2K1 ATF4 ATF4 CARD11 CARD11 LOC102747252 LOC102747252 NFATC3 NFATC3 PRKCH PRKCH JUNB JUNB LOC102739066 LOC102739066 EEF2K EEF2K DDIT4 DDIT4 DUSP7 DUSP7 MAPK7 MAPK7 CEBPB CEBPB MAP2K6 MAP2K6 PTPRR PTPRR TBC1D7 TBC1D7 CREB1 CREB1 MAP2K7 MAP2K7 SGK3 SGK3 SGK2 SGK2 PRKCQ PRKCQ EGR2 EGR2 ATF1 ATF1 YWHAB YWHAB MAPK12 MAPK12 MAPK8IP2 MAPK8IP2 MTOR MTOR CREM CREM CCM2 CCM2 BATF2 BATF2 CDC25C CDC25C EGR1 EGR1 FOXO4 FOXO4 LOC102729240 LOC102729240 DUSP1 DUSP1 PKN1 PKN1 MAPK8 MAPK8 AKT1 AKT1 TFE3 TFE3 ATF6B ATF6B FOSB FOSB PKN2 PKN2 CREB3L3 CREB3L3 SMYD3 SMYD3 ATF6 ATF6 MAP2K2 MAP2K2 DUSP6 DUSP6 LOC102730047 LOC102730047 SPRY4 SPRY4 JUN JUN MOS MOS AKT3 AKT3 RAF1 RAF1 RPS6KB1 RPS6KB1 LOC102736999 LOC102736999 MAP3K1 MAP3K1 LOC102730470 LOC102730470 BCL10 BCL10 CARD10 CARD10 MAP3K3 MAP3K3 EGR3 EGR3 DUSP8 DUSP8 RPS6KA3 RPS6KA3 SIRT3 SIRT3 LRRC56 LRRC56 ATF2 ATF2 RICTOR RICTOR MAP3K6 MAP3K6 BATF BATF MAPK1 MAPK1 CREB3 CREB3 LOC102750756 LOC102750756 ATF3 ATF3 ATF5 ATF5 MAPKAP1 MAPKAP1 PRR5 PRR5 MAPK15 MAPK15 DEPTOR DEPTOR FOS FOS LOC102742022 LOC102742022 FOXO6 FOXO6 JUND JUND MAP2K3 MAP2K3 LOC102732719 LOC102732719 LOC102735118 LOC102735118 PTPN5 PTPN5 CREBBP CREBBP MAP3K2 MAP3K2 GRB7 GRB7 LOC102734131 LOC102734131 MPZ MPZ YWHAH YWHAH CREB3L1 CREB3L1 LOC102738241 LOC102738241 LOC102732653 LOC102732653 PTPN7 PTPN7 NAB2 NAB2 PKN3 PKN3 WFS1 WFS1 LOC102737163 LOC102737163 DDIT3 DDIT3 LOC102744498 LOC102744498 FOXO1 FOXO1 IER2 IER2 MAPK8IP1 MAPK8IP1 AKT1S1 AKT1S1 LOC102735556 LOC102735556 RPS6KB2 RPS6KB2 LOC102731352 LOC102731352 LOC102736146 LOC102736146 MAPK11 MAPK11 LOC102749849 LOC102749849 LOC102750518 LOC102750518 LOC102728311 LOC102728311 LOC102730942 LOC102730942 CARD14 CARD14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X2. (483 aa)
TFEBTranscription factor EB. (329 aa)
FOXO3Forkhead box protein O3. (672 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
LOC102747252Protein kinase C eta type-like. (89 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
PRKCHProtein kinase C eta type-like. (454 aa)
JUNBTranscription factor jun-B. (347 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
EEF2KEukaryotic elongation factor 2 kinase. (544 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (406 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R isoform X1. (655 aa)
TBC1D7TBC1 domain family member 7 isoform X1. (293 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK8IP2c-Jun-amino-terminal kinase-interacting protein 2. (831 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CREMcAMP-responsive element modulator isoform X1. (344 aa)
CCM2Malcavernin. (447 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (473 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
FOXO4Forkhead box protein O4 isoform X1. (506 aa)
LOC102729240CCAAT/enhancer-binding protein gamma-like. (145 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PKN1Serine/threonine-protein kinase N1. (796 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TFE3Transcription factor E3 isoform X1. (571 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
FOSBProtein fosB isoform X1. (335 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (984 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
SMYD3Histone-lysine N-methyltransferase SMYD3. (190 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (563 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC102730047Tuberin-like. (353 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
MOSProto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (348 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
LOC102730470Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
CARD10Caspase recruitment domain-containing protein 10. (1029 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (600 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
DUSP8Dual specificity protein phosphatase 8. (394 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
LRRC56Leucine-rich repeat-containing protein 56. (554 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1204 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (220 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (280 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (122 aa)
PRR5Proline-rich protein 5. (293 aa)
MAPK15Mitogen-activated protein kinase. (559 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (305 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
LOC10274202214-3-3 protein zeta/delta-like isoform X1; Belongs to the 14-3-3 family. (245 aa)
FOXO6Forkhead box protein O6. (397 aa)
JUNDTranscription factor jun-D. (298 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102732719Ribosomal protein S6 kinase alpha-1-like. (200 aa)
LOC102735118Transcription factor MafB-like. (323 aa)
PTPN5Tyrosine-protein phosphatase non-receptor type 5 isoform X1. (539 aa)
CREBBPCREB-binding protein-like. (1411 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (540 aa)
GRB7Growth factor receptor-bound protein 7. (403 aa)
LOC102734131Fos-related antigen 2-like. (241 aa)
MPZMyelin protein P0. (248 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
LOC102732653Nuclear receptor subfamily 4 group A member 1-like. (306 aa)
PTPN7Tyrosine-protein phosphatase non-receptor type 7. (301 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
PKN3Serine/threonine-protein kinase N3. (889 aa)
WFS1Wolframin-like. (882 aa)
LOC102737163Tyrosine-protein phosphatase non-receptor type 3-like. (442 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC10274449814-3-3 protein theta-like; Belongs to the 14-3-3 family. (98 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
IER2Immediate early response gene 2 protein. (223 aa)
MAPK8IP1c-Jun-amino-terminal kinase-interacting protein 1. (669 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102749849Microphthalmia-associated transcription factor-like. (181 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102728311Cyclic AMP-dependent transcription factor ATF-6 alpha-like. (185 aa)
LOC102730942NGFI-A-binding protein 1-like. (273 aa)
CARD14LOW QUALITY PROTEIN: caspase recruitment domain family, member 14. (510 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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