(16 nodes) PGBD-like superfamily, and Protease inhibitor I35 (TIMP) network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPP1	Osteopontin isoform X1. (299 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	TIMP1	Metalloproteinase inhibitor 1. (207 aa)
	MMP16	Matrix metalloproteinase-16. (613 aa)
	TIMP4	Metalloproteinase inhibitor 4. (224 aa)
	LOC102743592	Metalloproteinase inhibitor 2-like. (209 aa)
	TIMP3	Metalloproteinase inhibitor 3. (143 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (852 aa)
	MMP9	Matrix metalloproteinase-9. (704 aa)
	LOC102734300	Matrilysin-like. (274 aa)
	MMP3	Stromelysin-1. (476 aa)
	MMP13	Collagenase 3. (470 aa)
	MMP25	Matrix metalloproteinase-25. (559 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	MMP17	Matrix metalloproteinase-17. (357 aa)
	MMP27	Matrix metalloproteinase-27. (398 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	HBEGF	A0A2U3Y1U7	A0A2U3XJ45	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Proheparin-binding EGF-like growth factor.	0.759
ADAM17	LOC102734300	A0A2U3Y1U7	A0A2U3YCA1	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Matrilysin-like.	0.478
ADAM17	LOC102743592	A0A2U3Y1U7	A0A2U3XSB2	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Metalloproteinase inhibitor 2-like.	0.664
ADAM17	MMP14	A0A2U3Y1U7	A0A2U3YSI0	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Matrix metalloproteinase-14.	0.491
ADAM17	MMP3	A0A2U3Y1U7	A0A2U3YCC8	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Stromelysin-1.	0.780
ADAM17	MMP9	A0A2U3Y1U7	A0A2U3Y7X3	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Matrix metalloproteinase-9.	0.491
ADAM17	TIMP1	A0A2U3Y1U7	A0A2U3XLN1	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Metalloproteinase inhibitor 1.	0.504
ADAM17	TIMP3	A0A2U3Y1U7	A0A2U3XYC6	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Metalloproteinase inhibitor 3.	0.931
ADAM17	TIMP4	A0A2U3Y1U7	A0A2U3XRL9	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	Metalloproteinase inhibitor 4.	0.531
HBEGF	ADAM17	A0A2U3XJ45	A0A2U3Y1U7	Proheparin-binding EGF-like growth factor.	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	0.759
HBEGF	LOC102734300	A0A2U3XJ45	A0A2U3YCA1	Proheparin-binding EGF-like growth factor.	Matrilysin-like.	0.491
HBEGF	MMP13	A0A2U3XJ45	A0A2U3YCN5	Proheparin-binding EGF-like growth factor.	Collagenase 3.	0.464
HBEGF	MMP14	A0A2U3XJ45	A0A2U3YSI0	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-14.	0.897
HBEGF	MMP16	A0A2U3XJ45	A0A2U3XQW6	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-16.	0.898
HBEGF	MMP17	A0A2U3XJ45	A0A2U3YTX7	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-17.	0.899
HBEGF	MMP25	A0A2U3XJ45	A0A2U3YHN6	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-25.	0.816
HBEGF	MMP27	A0A2U3XJ45	A0A2U3Z4S6	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-27.	0.414
HBEGF	MMP3	A0A2U3XJ45	A0A2U3YCC8	Proheparin-binding EGF-like growth factor.	Stromelysin-1.	0.704
HBEGF	MMP9	A0A2U3XJ45	A0A2U3Y7X3	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-9.	0.939
LOC102734300	ADAM17	A0A2U3YCA1	A0A2U3Y1U7	Matrilysin-like.	Disintegrin and metalloproteinase domain-containing protein 17 isoform X1.	0.478