(17 nodes) Displacement of DNA glycosylase by APEX1, and DNA glycosylase/AP lyase, H2TH DNA-binding network (Leptonychotes weddellii)

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Your Input:
	NEIL3	Endonuclease 8-like 3. (651 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (519 aa)
	NEIL2	Endonuclease 8-like 2. (334 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
	MPG	DNA-3-methyladenine glycosylase. (267 aa)
	OGG1	N-glycosylase/DNA lyase isoform X2. (334 aa)
	TDP2	tyrosyl-DNA phosphodiesterase 2. (358 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (314 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	NEIL1	Endonuclease 8-like 1. (383 aa)
	LOC102732340	DNA-(Apurinic or apyrimidinic site) lyase 2-like. (90 aa)
	PPP2R3B	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (596 aa)
	LOC102744185	tyrosyl-DNA phosphodiesterase 1-like. (361 aa)
	LOC102732741	uracil-DNA glycosylase-like. (177 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (231 aa)
	LOC102733454	DNA-(Apurinic or apyrimidinic site) lyase 2-like. (344 aa)
	SPRTN	sprT-like domain-containing protein Spartan. (484 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	LOC102732340	A0A2U3XIY3	A0A2U3YWC6	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	0.793
APEX1	LOC102732741	A0A2U3XIY3	A0A2U3Z2A1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	uracil-DNA glycosylase-like.	0.753
APEX1	LOC102733454	A0A2U3XIY3	A0A2U3Z584	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	0.829
APEX1	LOC102744185	A0A2U3XIY3	A0A2U3Z0L6	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	tyrosyl-DNA phosphodiesterase 1-like.	0.515
APEX1	MPG	A0A2U3XIY3	A0A2U3XLE2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-3-methyladenine glycosylase.	0.624
APEX1	MUTYH	A0A2U3XIY3	A0A2U3XC60	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.783
APEX1	NEIL1	A0A2U3XIY3	A0A2U3YLP3	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease 8-like 1.	0.482
APEX1	NTHL1	A0A2U3XIY3	A0A2U3YE14	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.987
APEX1	OGG1	A0A2U3XIY3	A0A2U3Y5R8	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	N-glycosylase/DNA lyase isoform X2.	0.804
APEX1	POLB	A0A2U3XIY3	A0A2U3YJX7	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.987
LOC102732340	APEX1	A0A2U3YWC6	A0A2U3XIY3	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.793
LOC102732340	LOC102732741	A0A2U3YWC6	A0A2U3Z2A1	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	uracil-DNA glycosylase-like.	0.662
LOC102732340	LOC102733454	A0A2U3YWC6	A0A2U3Z584	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	0.937
LOC102732340	LOC102744185	A0A2U3YWC6	A0A2U3Z0L6	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	tyrosyl-DNA phosphodiesterase 1-like.	0.444
LOC102732340	MPG	A0A2U3YWC6	A0A2U3XLE2	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	DNA-3-methyladenine glycosylase.	0.567
LOC102732340	MUTYH	A0A2U3YWC6	A0A2U3XC60	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.723
LOC102732340	NTHL1	A0A2U3YWC6	A0A2U3YE14	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.760
LOC102732340	OGG1	A0A2U3YWC6	A0A2U3Y5R8	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	N-glycosylase/DNA lyase isoform X2.	0.693
LOC102732340	POLB	A0A2U3YWC6	A0A2U3YJX7	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.625
LOC102732340	SPRTN	A0A2U3YWC6	A0A2U3Z764	DNA-(Apurinic or apyrimidinic site) lyase 2-like.	sprT-like domain-containing protein Spartan.	0.498