(16 nodes) Proteasome regulatory particle network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMD4	26S proteasome non-ATPase regulatory subunit 4. (377 aa)
	PSMC2	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
	PSMC6	26S protease regulatory subunit 10B. (291 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	PSMC5	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
	PSMD8	LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8. (351 aa)
	PSMD7	26S proteasome non-ATPase regulatory subunit 7-like. (324 aa)
	PSMD11	26S proteasome non-ATPase regulatory subunit 11. (422 aa)
	ADRM1	Proteasomal ubiquitin receptor ADRM1 isoform X1. (406 aa)
	LOC102735127	26S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family. (440 aa)
	CSF3	Granulocyte colony-stimulating factor. (195 aa)
	LOC102726381	26S proteasome non-ATPase regulatory subunit 1-like. (574 aa)
	PSMD6	26S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa)
	LOC102729219	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (778 aa)
	LOC102730851	26S protease regulatory subunit 6A-like. (200 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	CSF3	A0A2U3YLT7	A0A2U3Z1Q3	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Granulocyte colony-stimulating factor.	0.996
ADRM1	LOC102726381	A0A2U3YLT7	A0A2U3Z331	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 1-like.	0.967
ADRM1	LOC102729219	A0A2U3YLT7	A0A2U3Z6Q4	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.965
ADRM1	LOC102730851	A0A2U3YLT7	A0A2U3Z8X8	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 6A-like.	0.993
ADRM1	LOC102735127	A0A2U3YLT7	A0A2U3YX40	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family.	0.998
ADRM1	PSMC2	A0A2U3YLT7	A0A2U3XKI5	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 7; Belongs to the AAA ATPase family.	0.995
ADRM1	PSMC5	A0A2U3YLT7	A0A2U3Y1V0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.992
ADRM1	PSMC6	A0A2U3YLT7	A0A2U3XVY8	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 10B.	0.994
ADRM1	PSMD11	A0A2U3YLT7	A0A2U3YLC9	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 11.	0.994
ADRM1	PSMD14	A0A2U3YLT7	A0A2U3XX14	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 14.	0.968
ADRM1	PSMD4	A0A2U3YLT7	A0A2U3XAA6	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 4.	0.997
ADRM1	PSMD6	A0A2U3YLT7	A0A2U3Z4T4	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 6 isoform X1.	0.993
ADRM1	PSMD7	A0A2U3YLT7	A0A2U3YFT3	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 7-like.	0.993
ADRM1	PSMD8	A0A2U3YLT7	A0A2U3Y6T8	Proteasomal ubiquitin receptor ADRM1 isoform X1.	LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8.	0.993
ADRM1	USP14	A0A2U3YLT7	A0A2U3XNP3	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.919
CSF3	ADRM1	A0A2U3Z1Q3	A0A2U3YLT7	Granulocyte colony-stimulating factor.	Proteasomal ubiquitin receptor ADRM1 isoform X1.	0.996
CSF3	LOC102726381	A0A2U3Z1Q3	A0A2U3Z331	Granulocyte colony-stimulating factor.	26S proteasome non-ATPase regulatory subunit 1-like.	0.972
CSF3	LOC102729219	A0A2U3Z1Q3	A0A2U3Z6Q4	Granulocyte colony-stimulating factor.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.984
CSF3	LOC102730851	A0A2U3Z1Q3	A0A2U3Z8X8	Granulocyte colony-stimulating factor.	26S protease regulatory subunit 6A-like.	0.998
CSF3	LOC102735127	A0A2U3Z1Q3	A0A2U3YX40	Granulocyte colony-stimulating factor.	26S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family.	0.998