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ACO1 ACO1 BCAT1 BCAT1 HMGCLL1 HMGCLL1 LOC102727267 LOC102727267 OGDHL OGDHL BCKDHB BCKDHB SDHAF2 SDHAF2 GCDH GCDH IDH3B IDH3B PDHX PDHX DLAT DLAT SDHD SDHD IDH1 IDH1 OGDH OGDH SUCLA2 SUCLA2 LOC102749675 LOC102749675 IDH3G IDH3G ACO2 ACO2 CS CS FAHD1 FAHD1 SDHA SDHA IDH2 IDH2 DLD DLD FH FH LOC102730690 LOC102730690 SDHC SDHC PDHB PDHB TXNRD2 TXNRD2 LOC102732141 LOC102732141 BCKDHA BCKDHA LOC102742579 LOC102742579 LOC102732460 LOC102732460
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACO1Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (889 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (398 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1. (340 aa)
LOC102727267Succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like. (167 aa)
OGDHL2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1. (1006 aa)
BCKDHB2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. (278 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
GCDHglutaryl-CoA dehydrogenase, mitochondrial isoform X1. (438 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
OGDH2-oxoglutarate dehydrogenase, mitochondrial isoform X1. (1038 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
LOC102749675Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
FAHD1Acylpyruvase FAHD1, mitochondrial. (221 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial. (338 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
LOC102730690Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (384 aa)
SDHCSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1. (169 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
TXNRD2Thioredoxin reductase 2, mitochondrial. (425 aa)
LOC102732141Iron-responsive element-binding protein 2-like. (229 aa)
BCKDHA2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
LOC102742579Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like. (248 aa)
LOC102732460Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like. (534 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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