STRINGSTRING
FGF16 FGF16 EPHA5 EPHA5 PSKH2 PSKH2 PAG1 PAG1 PDGFC PDGFC FGF20 FGF20 EPHA7 EPHA7 PDGFRL PDGFRL YES1 YES1 FGF9 FGF9 GJA1 GJA1 NCK1 NCK1 LOC102726446 LOC102726446 TGFA TGFA CBLB CBLB EPHA3 EPHA3 PTPRJ PTPRJ ERBB3 ERBB3 KL KL MET MET PIK3R3 PIK3R3 FRS3 FRS3 LOC102742552 LOC102742552 FGF10 FGF10 EREG EREG EPGN EPGN LOC102741253 LOC102741253 LOC102728392 LOC102728392 ITK ITK LOC102749335 LOC102749335 FGF8 FGF8 LOC102740357 LOC102740357 LOC102740565 LOC102740565 ANGPT1 ANGPT1 GRAP GRAP PTPN12 PTPN12 KLB KLB LOC102725595 LOC102725595 PAK7 PAK7 FGFR4 FGFR4 SRC SRC EPHB4 EPHB4 CD19 CD19 SH2B1 SH2B1 LOC102745868 LOC102745868 NRG1 NRG1 LOC102731157 LOC102731157 EFNA1 EFNA1 SHC1 SHC1 DCST2 DCST2 GAB1 GAB1 FLRT3 FLRT3 LCP2 LCP2 PREX1 PREX1 FGF7 FGF7 IRS1 IRS1 PTPN11 PTPN11 NTF3 NTF3 LOC102737884 LOC102737884 GRB10 GRB10 VAV3 VAV3 FGFR3 FGFR3 LTK LTK LOC102728321 LOC102728321 SHC4 SHC4 TEK TEK JAK2 JAK2 FGF5 FGF5 EPHB2 EPHB2 BTK BTK FAM150B FAM150B EPHB3 EPHB3 IGF1R IGF1R FGFR2 FGFR2 EFNB3 EFNB3 KITLG KITLG NGF NGF NTRK2 NTRK2 LOC102741496 LOC102741496 PAK1 PAK1 PIR PIR CBL CBL LOC102749673 LOC102749673 RUFY1 RUFY1 VEGFC VEGFC CSK CSK ARHGEF7 ARHGEF7 TEC TEC GIT1 GIT1 ANGPT2 ANGPT2 LRRK1 LRRK1 FGFBP1 FGFBP1 RAC2 RAC2 SLA2 SLA2 PAK2 PAK2 EPHA4 EPHA4 LOC102728858 LOC102728858 PTPN2 PTPN2 TIAM1 TIAM1 INSRR INSRR LOC102735415 LOC102735415 EPOR EPOR LOC102747801 LOC102747801 CRKL CRKL FGF17 FGF17 LOC102737920 LOC102737920 KIDINS220 KIDINS220 ARHGEF6 ARHGEF6 LOC102737823 LOC102737823 FGF3 FGF3 FGF4 FGF4 LOC102741827 LOC102741827 FGF18 FGF18 INPPL1 INPPL1 PGF PGF LOC102733219 LOC102733219 PIK3CA PIK3CA ANGPT4 ANGPT4 VAV2 VAV2 FLT3 FLT3 VEGFB VEGFB FGFRL1 FGFRL1 PDGFB PDGFB LOC102737030 LOC102737030 LOC102736516 LOC102736516 LOC102735329 LOC102735329 LOC102730084 LOC102730084 PDGFRA PDGFRA FGF21 FGF21 EPHA1 EPHA1 MDK MDK NCK2 NCK2 CBLC CBLC NTRK1 NTRK1 LOC102747142 LOC102747142 FLT3LG FLT3LG PAK6 PAK6 JAK3 JAK3 LOC102741259 LOC102741259 LOC102744912 LOC102744912 LOC102731850 LOC102731850 LOC102740057 LOC102740057 FGF6 FGF6 FGF23 FGF23 LOC102745745 LOC102745745 LOC102740654 LOC102740654 FGF2 FGF2 NTF4 NTF4 LOC102728297 LOC102728297 MATK MATK FGF22 FGF22 LOC102744822 LOC102744822 TIE1 TIE1 LOC102725972 LOC102725972 LOC102748833 LOC102748833 LOC102725895 LOC102725895 LOC102733359 LOC102733359 LOC102746252 LOC102746252 LOC102748045 LOC102748045 LOC102742177 LOC102742177 LOC102740168 LOC102740168 LOC102751021 LOC102751021 LOC102730129 LOC102730129 LOC102750030 LOC102750030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1039 aa)
PSKH2Serine/threonine-protein kinase H2; Belongs to the protein kinase superfamily. (325 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (434 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
EPHA7Ephrin type-A receptor 7-like isoform X1. (998 aa)
PDGFRLPlatelet-derived growth factor receptor-like protein. (387 aa)
YES1Tyrosine-protein kinase. (541 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
NCK1Cytoplasmic protein. (377 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
TGFAProtransforming growth factor alpha. (160 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1218 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
KLKlotho. (1081 aa)
METHepatocyte growth factor receptor. (756 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
EREGProepiregulin. (292 aa)
EPGNEpigen isoform X1. (153 aa)
LOC102741253Amphiregulin-like. (253 aa)
LOC102728392ephrin-A5-like; Belongs to the ephrin family. (191 aa)
ITKTyrosine-protein kinase. (486 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
LOC102740565Pro-neuregulin-2, membrane-bound isoform-like. (410 aa)
ANGPT1Angiopoietin-1 isoform X1. (402 aa)
GRAPGRB2-related adapter protein. (210 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12 isoform X3. (782 aa)
KLBBeta-klotho. (1037 aa)
LOC102725595Fibroblast growth factor receptor substrate 2-like. (316 aa)
PAK7Serine/threonine-protein kinase PAK 7. (474 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
SRCTyrosine-protein kinase. (536 aa)
EPHB4Ephrin type-B receptor 4 isoform X1. (988 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
SH2B1SH2B adapter protein 1 isoform X3. (688 aa)
LOC102745868Pro-neuregulin-1, membrane-bound isoform-like. (92 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (694 aa)
LOC102731157ARF GTPase-activating protein GIT1-like. (191 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
DCST2LOW QUALITY PROTEIN: DC-STAMP domain-containing protein 2. (766 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3 isoform X1. (649 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1642 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
LOC102737884Tyrosine-protein kinase. (539 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (841 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
SHC4SHC-transforming protein 4. (630 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
JAK2Tyrosine-protein kinase. (952 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
EPHB2Ephrin type-B receptor 2-like isoform X1. (545 aa)
BTKTyrosine-protein kinase. (659 aa)
FAM150BProtein FAM150B. (150 aa)
EPHB3Ephrin type-B receptor 3. (883 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
FGFR2Fibroblast growth factor receptor 2. (658 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
NTRK2BDNF/NT-3 growth factors receptor-like. (420 aa)
LOC102741496BDNF/NT-3 growth factors receptor-like. (97 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PIRPirin. (132 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
RUFY1RUN and FYVE domain-containing protein 1 isoform X1. (600 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
CSKTyrosine-protein kinase. (450 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (625 aa)
TECTyrosine-protein kinase. (630 aa)
GIT1ARF GTPase-activating protein GIT1-like. (481 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (576 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
SLA2Src-like-adapter 2. (276 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
LOC102728858Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family. (251 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
INSRRTyrosine-protein kinase receptor. (1380 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
CRKLCrk-like protein. (303 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC102737920GRB2-related adapter protein-like. (100 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X2. (1753 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (508 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
LOC102741827ephrin-B1-like; Belongs to the ephrin family. (247 aa)
FGF18Fibroblast growth factor 18. (116 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1249 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
LOC102733219Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ANGPT4Angiopoietin-4. (498 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (508 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
LOC102730084Growth factor receptor-bound protein 14-like. (226 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
EPHA1Ephrin type-A receptor 1. (976 aa)
MDKMidkine isoform X1. (143 aa)
NCK2Cytoplasmic protein. (380 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (496 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
LOC102747142Tyrosine-protein kinase. (395 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (290 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
LOC102741259Serine/threonine-protein kinase PAK 3-like. (339 aa)
LOC102744912Myosin light chain kinase, smooth muscle-like isoform X2. (266 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
FGF23Fibroblast growth factor 23. (177 aa)
LOC102745745Tyrosine-protein kinase receptor. (302 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
LOC102728297Serine/threonine-protein kinase PAK 7-like. (225 aa)
MATKTyrosine-protein kinase. (496 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (1015 aa)
LOC102725972Cytoplasmic tyrosine-protein kinase BMX-like. (151 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102725895Ephrin type-A receptor 8-like. (743 aa)
LOC102733359ephrin-A4-like; Belongs to the ephrin family. (166 aa)
LOC102746252Tyrosine-protein kinase Fes/Fps-like. (444 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
LOC102740168Hepatocyte growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (478 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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