(45 nodes) Fibroblast growth factor receptor binding, and PDGF/VEGF domain network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

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Your Input:
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	PDGFC	Platelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	PDGFRL	Platelet-derived growth factor receptor-like protein. (387 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TGFA	Protransforming growth factor alpha. (160 aa)
	KL	Klotho. (1081 aa)
	LOC102742552	Platelet-derived growth factor D-like isoform X1. (370 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
	KLB	Beta-klotho. (1037 aa)
	FGFR4	Fibroblast growth factor receptor. (800 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	FGFR2	Fibroblast growth factor receptor 2. (658 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	PIR	Pirin. (132 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	FGFBP1	Fibroblast growth factor-binding protein 1. (255 aa)
	INSRR	Tyrosine-protein kinase receptor. (1380 aa)
	LOC102747801	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC102737823	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	FGF18	Fibroblast growth factor 18. (116 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	LOC102733219	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1. (508 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	LOC102735329	Vascular endothelial growth factor receptor 1-like. (351 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	NTRK1	Tyrosine-protein kinase receptor. (592 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	LOC102742177	Mast/stem cell growth factor receptor Kit-like. (217 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF10	FGF16	A0A2U3XE64	A0A2U3X658	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.482
FGF10	FGF18	A0A2U3XE64	A0A2U3YP56	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.504
FGF10	FGF2	A0A2U3XE64	A0A2U3Z312	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
FGF10	FGF23	A0A2U3XE64	A0A2U3Z274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.671
FGF10	FGF3	A0A2U3XE64	A0A2U3YNN2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
FGF10	FGF4	A0A2U3XE64	A0A2U3YP27	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.525
FGF10	FGF6	A0A2U3XE64	A0A2U3Z272	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
FGF10	FGF8	A0A2U3XE64	A0A2U3XI44	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.546
FGF10	FGFBP1	A0A2U3XE64	A0A2U3YDK0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor-binding protein 1.	0.750
FGF10	FGFR2	A0A2U3XE64	A0A2U3Y5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 2.	0.974
FGF10	FGFR3	A0A2U3XE64	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.947
FGF10	FGFR4	A0A2U3XE64	A0A2U3XP14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.945
FGF10	FGFRL1	A0A2U3XE64	A0A2U3YSX9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor-like 1.	0.759
FGF10	IGF1R	A0A2U3XE64	A0A2U3Y3Q9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin-like growth factor 1 receptor-like.	0.802
FGF10	INSRR	A0A2U3XE64	A0A2U3YKS4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.811
FGF10	KITLG	A0A2U3XE64	A0A2U3Y5X8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.500
FGF10	KL	A0A2U3XE64	A0A2U3XC26	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Klotho.	0.563
FGF10	KLB	A0A2U3XE64	A0A2U3XLL2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Beta-klotho.	0.527
FGF10	LOC102730129	A0A2U3XE64	A0A2U3Z8I1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein LOC102730129.	0.442
FGF10	LOC102735329	A0A2U3XE64	A0A2U3YU32	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor receptor 1-like.	0.860