(30 nodes) Fibroblast growth factor receptor binding, and Fibroblast growth factor receptor activity network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KL	Klotho. (1081 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
	KLB	Beta-klotho. (1037 aa)
	FGFR4	Fibroblast growth factor receptor. (800 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	FGFR2	Fibroblast growth factor receptor 2. (658 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	INSRR	Tyrosine-protein kinase receptor. (1380 aa)
	LOC102747801	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC102737823	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	FGF18	Fibroblast growth factor 18. (116 aa)
	LOC102733219	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1. (508 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	NTRK1	Tyrosine-protein kinase receptor. (592 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	LOC102742177	Mast/stem cell growth factor receptor Kit-like. (217 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF16	FGF18	A0A2U3X658	A0A2U3YP56	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.522
FGF16	FGF2	A0A2U3X658	A0A2U3Z312	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
FGF16	FGF22	A0A2U3X658	A0A2U3Z594	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
FGF16	FGF23	A0A2U3X658	A0A2U3Z274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.685
FGF16	FGF3	A0A2U3X658	A0A2U3YNN2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
FGF16	FGF4	A0A2U3X658	A0A2U3YP27	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
FGF16	FGF6	A0A2U3X658	A0A2U3Z272	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
FGF16	FGF7	A0A2U3X658	A0A2U3XW34	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.400
FGF16	FGF8	A0A2U3X658	A0A2U3XI44	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
FGF16	FGFR2	A0A2U3X658	A0A2U3Y5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 2.	0.966
FGF16	FGFR3	A0A2U3X658	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.946
FGF16	FGFR4	A0A2U3X658	A0A2U3XP14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.935
FGF16	FGFRL1	A0A2U3X658	A0A2U3YSX9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor-like 1.	0.604
FGF16	IGF1R	A0A2U3X658	A0A2U3Y3Q9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin-like growth factor 1 receptor-like.	0.800
FGF16	INSRR	A0A2U3X658	A0A2U3YKS4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.813
FGF16	KITLG	A0A2U3X658	A0A2U3Y5X8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.505
FGF16	KL	A0A2U3X658	A0A2U3XC26	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Klotho.	0.625
FGF16	KLB	A0A2U3X658	A0A2U3XLL2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Beta-klotho.	0.591
FGF16	LOC102737823	A0A2U3X658	A0A2U3YNM9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.492
FGF16	LOC102742177	A0A2U3X658	A0A2U3Z7D6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mast/stem cell growth factor receptor Kit-like.	0.859