(16 nodes) FGFR4 ligand binding and activation, and Melanocyte migration network (Leptonychotes weddellii)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KL	Klotho. (1081 aa)
	KLB	Beta-klotho. (1037 aa)
	FGFR4	Fibroblast growth factor receptor. (800 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	FGFR2	Fibroblast growth factor receptor 2. (658 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	LOC102747801	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC102737823	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	LOC102742177	Mast/stem cell growth factor receptor Kit-like. (217 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF17	FGF2	A0A2U3YM04	A0A2U3Z312	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.762
FGF17	FGF22	A0A2U3YM04	A0A2U3Z594	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.668
FGF17	FGF23	A0A2U3YM04	A0A2U3Z274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.702
FGF17	FGFR2	A0A2U3YM04	A0A2U3Y5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 2.	0.937
FGF17	FGFR3	A0A2U3YM04	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.928
FGF17	FGFR4	A0A2U3YM04	A0A2U3XP14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.913
FGF17	KITLG	A0A2U3YM04	A0A2U3Y5X8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.507
FGF17	KL	A0A2U3YM04	A0A2U3XC26	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Klotho.	0.568
FGF17	KLB	A0A2U3YM04	A0A2U3XLL2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Beta-klotho.	0.527
FGF17	LOC102737823	A0A2U3YM04	A0A2U3YNM9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.430
FGF17	LOC102742177	A0A2U3YM04	A0A2U3Z7D6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mast/stem cell growth factor receptor Kit-like.	0.855
FGF17	LOC102744822	A0A2U3YM04	A0A2U3Z5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.683
FGF17	LOC102747801	A0A2U3YM04	A0A2U3YLJ1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
FGF2	FGF17	A0A2U3Z312	A0A2U3YM04	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.762
FGF2	FGF21	A0A2U3Z312	A0A2U3YV39	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.713
FGF2	FGF22	A0A2U3Z312	A0A2U3Z594	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.747
FGF2	FGFR2	A0A2U3Z312	A0A2U3Y5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 2.	0.996
FGF2	FGFR3	A0A2U3Z312	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.992
FGF2	FGFR4	A0A2U3Z312	A0A2U3XP14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.991
FGF2	KITLG	A0A2U3Z312	A0A2U3Y5X8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.588