(5 nodes) GRB7 events in ERBB2 signaling network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERBB3	Receptor tyrosine-protein kinase erbB-3. (1339 aa)
	LOC102740565	Pro-neuregulin-2, membrane-bound isoform-like. (410 aa)
	LOC102745868	Pro-neuregulin-1, membrane-bound isoform-like. (92 aa)
	NRG1	Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (694 aa)
	LOC102737030	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERBB3	LOC102737030	A0A2U3XBG8	A0A2U3YTF2	Receptor tyrosine-protein kinase erbB-3.	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.997
ERBB3	LOC102740565	A0A2U3XBG8	A0A2U3XJ94	Receptor tyrosine-protein kinase erbB-3.	Pro-neuregulin-2, membrane-bound isoform-like.	0.783
ERBB3	LOC102745868	A0A2U3XBG8	A0A2U3XSQ6	Receptor tyrosine-protein kinase erbB-3.	Pro-neuregulin-1, membrane-bound isoform-like.	0.788
ERBB3	NRG1	A0A2U3XBG8	A0A2U3XSV6	Receptor tyrosine-protein kinase erbB-3.	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	0.999
LOC102737030	ERBB3	A0A2U3YTF2	A0A2U3XBG8	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Receptor tyrosine-protein kinase erbB-3.	0.997
LOC102737030	LOC102740565	A0A2U3YTF2	A0A2U3XJ94	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Pro-neuregulin-2, membrane-bound isoform-like.	0.783
LOC102737030	LOC102745868	A0A2U3YTF2	A0A2U3XSQ6	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Pro-neuregulin-1, membrane-bound isoform-like.	0.788
LOC102737030	NRG1	A0A2U3YTF2	A0A2U3XSV6	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	0.996
LOC102740565	ERBB3	A0A2U3XJ94	A0A2U3XBG8	Pro-neuregulin-2, membrane-bound isoform-like.	Receptor tyrosine-protein kinase erbB-3.	0.783
LOC102740565	LOC102737030	A0A2U3XJ94	A0A2U3YTF2	Pro-neuregulin-2, membrane-bound isoform-like.	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.783
LOC102740565	NRG1	A0A2U3XJ94	A0A2U3XSV6	Pro-neuregulin-2, membrane-bound isoform-like.	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	0.899
LOC102745868	ERBB3	A0A2U3XSQ6	A0A2U3XBG8	Pro-neuregulin-1, membrane-bound isoform-like.	Receptor tyrosine-protein kinase erbB-3.	0.788
LOC102745868	LOC102737030	A0A2U3XSQ6	A0A2U3YTF2	Pro-neuregulin-1, membrane-bound isoform-like.	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.788
LOC102745868	NRG1	A0A2U3XSQ6	A0A2U3XSV6	Pro-neuregulin-1, membrane-bound isoform-like.	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	0.861
NRG1	ERBB3	A0A2U3XSV6	A0A2U3XBG8	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	Receptor tyrosine-protein kinase erbB-3.	0.999
NRG1	LOC102737030	A0A2U3XSV6	A0A2U3YTF2	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.996
NRG1	LOC102740565	A0A2U3XSV6	A0A2U3XJ94	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	Pro-neuregulin-2, membrane-bound isoform-like.	0.899
NRG1	LOC102745868	A0A2U3XSV6	A0A2U3XSQ6	Pro-neuregulin-3, membrane-bound isoform-like isoform X1.	Pro-neuregulin-1, membrane-bound isoform-like.	0.861