(50 nodes) Ureteric bud development network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OSR1	Protein odd-skipped-related 1 isoform X1. (267 aa)
	GZF1	GDNF-inducible zinc finger protein 1. (719 aa)
	LOC102735151	Bone morphogenetic protein 7-like. (139 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	LOC102737253	Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
	LOC102750017	Mothers against decapentaplegic homolog 6-like. (181 aa)
	WT1	Wilms tumor protein-like. (413 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	CRLF1	Cytokine receptor-like factor 1. (527 aa)
	TMEM59L	Transmembrane protein 59-like. (350 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	KIF26B	Kinesin-like protein KIF26B-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (81 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	CER1	Cerberus. (274 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	LOC102746898	Protein GREB1-like. (1593 aa)
	BMP7	Bone morphogenetic protein 7-like. (312 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (319 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	LOC102737096	Retinoic acid receptor beta-like. (262 aa)
	TCF21	Transcription factor 21. (179 aa)
	TACSTD2	Tumor-associated calcium signal transducer 2. (323 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (302 aa)
	ARG2	Arginase. (354 aa)
	PTCH1	Protein patched homolog 1. (1301 aa)
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)
	RARB	Retinoic acid receptor beta. (172 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	DLG2	Disks large homolog 2 isoform X1. (905 aa)
	ILK	Integrin-linked protein kinase isoform X1. (452 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	HOXA11	Homeobox protein Hox-A11. (321 aa)
	LOC102731342	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
	GREM1	Gremlin. (184 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	CALB1	Calbindin. (261 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	BMPER	BMP-binding endothelial regulator protein-like. (446 aa)
	GDF11	Growth/differentiation factor 11. (372 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
	FOXJ1	Forkhead box protein J1. (421 aa)
	PKD2	Polycystin-2. (935 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP7	A0A2U3Z3S1	A0A2U3YG58	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.592
BMP2	BMPER	A0A2U3Z3S1	A0A2U3XBU2	Bone morphogenetic protein 2-like.	BMP-binding endothelial regulator protein-like.	0.415
BMP2	CER1	A0A2U3Z3S1	A0A2U3YL33	Bone morphogenetic protein 2-like.	Cerberus.	0.496
BMP2	FGF2	A0A2U3Z3S1	A0A2U3Z312	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.722
BMP2	GREM1	A0A2U3Z3S1	A0A2U3XFV2	Bone morphogenetic protein 2-like.	Gremlin.	0.820
BMP2	LOC102726900	A0A2U3Z3S1	A0A2U3XYM0	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 7-like.	0.709
BMP2	LOC102727345	A0A2U3Z3S1	A0A2U3YND0	Bone morphogenetic protein 2-like.	Transcription factor SOX-9-like.	0.549
BMP2	LOC102730318	A0A2U3Z3S1	A0A2U3Z2G6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.621
BMP2	LOC102735151	A0A2U3Z3S1	A0A2U3Z6A5	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.582
BMP2	LOC102740547	A0A2U3Z3S1	A0A2U3Z034	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 4-like isoform X1.	0.898
BMP2	LOC102744822	A0A2U3Z3S1	A0A2U3Z5B6	Bone morphogenetic protein 2-like.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.476
BMP2	LOC102750017	A0A2U3Z3S1	A0A2U3Z1Z6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 6-like.	0.743
BMP2	NOG	A0A2U3Z3S1	A0A2U3XEL8	Bone morphogenetic protein 2-like.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.971
BMP2	SMAD1	A0A2U3Z3S1	A0A2U3YKB3	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.800
BMP2	SMAD4	A0A2U3Z3S1	A0A2U3XTK1	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.820
BMP7	BMP2	A0A2U3YG58	A0A2U3Z3S1	Bone morphogenetic protein 7-like.	Bone morphogenetic protein 2-like.	0.592
BMP7	FGF2	A0A2U3YG58	A0A2U3Z312	Bone morphogenetic protein 7-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
BMP7	GREM1	A0A2U3YG58	A0A2U3XFV2	Bone morphogenetic protein 7-like.	Gremlin.	0.802
BMP7	LOC102726900	A0A2U3YG58	A0A2U3XYM0	Bone morphogenetic protein 7-like.	Mothers against decapentaplegic homolog 7-like.	0.542
BMP7	LOC102727345	A0A2U3YG58	A0A2U3YND0	Bone morphogenetic protein 7-like.	Transcription factor SOX-9-like.	0.475