(106 nodes) Tissue homeostasis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TP53INP1	Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
	TJP1	Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1770 aa)
	CLCN3	Chloride channel protein. (839 aa)
	USP45	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (816 aa)
	GPR98	G-protein coupled receptor 98-like; Belongs to the G-protein coupled receptor 2 family. (6261 aa)
	KIAA1211	Uncharacterized protein KIAA1211 homolog. (1224 aa)
	LOC102726171	LIM domain-binding protein 1-like. (190 aa)
	LOC102732851	LIM domain-binding protein 1-like. (227 aa)
	SNX10	Sorting nexin-10. (201 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (729 aa)
	PRDM14	PR domain zinc finger protein 14. (571 aa)
	HOMER1	Homer protein homolog 1 isoform X1. (354 aa)
	IQCB1	IQ calmodulin-binding motif-containing protein 1 isoform X1. (598 aa)
	ILDR1	Immunoglobulin-like domain-containing receptor 1. (595 aa)
	NCDN	Neurochondrin isoform X2. (712 aa)
	DRAM2	DNA damage-regulated autophagy modulator protein 2 isoform X2. (266 aa)
	LOC102732267	Clarin-1-like. (115 aa)
	WWTR1	WW domain-containing transcription regulator protein 1. (144 aa)
	NXNL2	Nucleoredoxin-like protein 2. (156 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	CRB1	Protein crumbs homolog 1 isoform X1. (1406 aa)
	LOC102735385	ATP-binding cassette sub-family A member 12-like. (1103 aa)
	LOC102747957	Meckel syndrome type 1 protein-like. (318 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (380 aa)
	F2R	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	SRF	Serum response factor. (508 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
	PTH1R	LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family. (608 aa)
	MFSD2A	Major facilitator superfamily domain-containing protein 2A isoform X1. (529 aa)
	BBS10	Bardet-Biedl syndrome 10 protein. (721 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha. (631 aa)
	GATA1	Erythroid transcription factor. (413 aa)
	STRAP	Serine-threonine kinase receptor-associated protein isoform X1. (350 aa)
	LOC102748980	Tight junction protein ZO-3-like. (348 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	LOC102741200	Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
	CTGF	Connective tissue growth factor. (211 aa)
	MAK	Serine/threonine-protein kinase MAK isoform X1. (649 aa)
	CYTL1	Cytokine-like protein 1. (133 aa)
	RHO	Rhodopsin. (348 aa)
	CD7	T-cell antigen CD7. (209 aa)
	CXADR	Coxsackievirus and adenovirus receptor homolog isoform X1. (365 aa)
	EPAS1	Endothelial PAS domain-containing protein 1. (865 aa)
	RB1	Retinoblastoma-associated protein. (846 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	TUB	Tubby-like protein; Belongs to the TUB family. (507 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
	LOC102747987	Nephrocystin-4-like. (369 aa)
	LRRC45	Leucine-rich repeat-containing protein 45. (670 aa)
	LDB2	LIM domain-binding protein 2-like isoform X1. (373 aa)
	ACP5	Tartrate-resistant acid phosphatase type 5. (335 aa)
	RAB3D	Ras-related protein Rab-3D. (219 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2. (191 aa)
	KLHL10	Kelch-like protein 10 isoform X1. (608 aa)
	LOC102729573	Usherin-like. (1546 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	NKIRAS1	NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	LOC102748798	Pulmonary surfactant-associated protein D-like. (269 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
	ZNF830	Zinc finger protein 830. (371 aa)
	CTSH	Pro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
	FH	Fumarate hydratase, mitochondrial. (508 aa)
	LPCAT1	Lysophosphatidylcholine acyltransferase 1. (447 aa)
	NXNL1	Nucleoredoxin-like protein 1. (219 aa)
	TRIM32	E3 ubiquitin-protein ligase TRIM32-like isoform X1. (655 aa)
	YAP1	Yorkie homolog. (326 aa)
	BBS1	Bardet-Biedl syndrome 1 protein. (540 aa)
	TFF3	Trefoil factor 3. (80 aa)
	COMP	Cartilage oligomeric matrix protein. (728 aa)
	IL17A	interleukin-17A. (155 aa)
	MKS1	Meckel syndrome type 1 protein. (262 aa)
	BBS2	Bardet-Biedl syndrome 2 protein-like. (603 aa)
	NAPSA	napsin-A; Belongs to the peptidase A1 family. (421 aa)
	RCN3	Reticulocalbin-3. (328 aa)
	VSIG1	V-set and immunoglobulin domain-containing protein 1. (411 aa)
	USH1C	Harmonin. (551 aa)
	LOC102744093	WW domain-containing transcription regulator protein 1-like. (286 aa)
	AIPL1	Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
	GPR55	G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
	TWF2	Toll-like receptor 9-like isoform X1. (1331 aa)
	LOC102744110	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
	LOC102725591	Alpha-adducin-like. (194 aa)
	LOC102727190	Serine/threonine-protein kinase STK11-like. (545 aa)
	PBLD	Phenazine biosynthesis-like domain-containing protein. (255 aa)
	LOC102743810	Vacuolar protein sorting-associated protein 54-like. (252 aa)
	LOC102740770	Tripeptidyl-peptidase 1-like. (572 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
	USH2A	Usherin-like. (2873 aa)
	USH1G	Usher syndrome type-1G protein isoform X1. (461 aa)
	ERCC6	DNA excision repair protein ERCC-6. (457 aa)
	SH3GL2	endophilin-A1. (352 aa)
	LOC102750488	Oxygen-regulated protein 1-like. (2144 aa)
	LCA5	Lebercilin. (699 aa)
	IAPP	Islet amyloid polypeptide. (89 aa)
	COL2A1	Collagen alpha-1(II) chain isoform X1. (1487 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
	GPR116	Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1. (576 aa)
	SPATA7	LOW QUALITY PROTEIN: spermatogenesis-associated protein 7. (603 aa)
	PIWIL4	Piwi-like protein 4; Belongs to the argonaute family. (814 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP5	LOC102744110	A0A2U3YKT6	A0A2U3Z6D0	Tartrate-resistant acid phosphatase type 5.	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family.	0.448
AIPL1	IQCB1	A0A2U3Z2W4	A0A2U3XKK5	Aryl-hydrocarbon-interacting protein-like 1.	IQ calmodulin-binding motif-containing protein 1 isoform X1.	0.499
AIPL1	LCA5	A0A2U3Z2W4	A0A2U3XBI6	Aryl-hydrocarbon-interacting protein-like 1.	Lebercilin.	0.493
AIPL1	RHO	A0A2U3Z2W4	A0A2U3Y9M5	Aryl-hydrocarbon-interacting protein-like 1.	Rhodopsin.	0.734
AIPL1	SPATA7	A0A2U3Z2W4	A0A2U3YEW7	Aryl-hydrocarbon-interacting protein-like 1.	LOW QUALITY PROTEIN: spermatogenesis-associated protein 7.	0.608
BBS1	BBS10	A0A2U3YVJ8	A0A2U3Y279	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 10 protein.	0.742
BBS1	BBS2	A0A2U3YVJ8	A0A2U3YZU5	Bardet-Biedl syndrome 1 protein.	Bardet-Biedl syndrome 2 protein-like.	0.999
BBS1	KLHL10	A0A2U3YVJ8	A0A2U3YLG1	Bardet-Biedl syndrome 1 protein.	Kelch-like protein 10 isoform X1.	0.608
BBS1	LOC102747987	A0A2U3YVJ8	A0A2U3YHI0	Bardet-Biedl syndrome 1 protein.	Nephrocystin-4-like.	0.401
BBS1	TRIM32	A0A2U3YVJ8	A0A2U3YV19	Bardet-Biedl syndrome 1 protein.	E3 ubiquitin-protein ligase TRIM32-like isoform X1.	0.489
BBS10	BBS1	A0A2U3Y279	A0A2U3YVJ8	Bardet-Biedl syndrome 10 protein.	Bardet-Biedl syndrome 1 protein.	0.742
BBS10	BBS2	A0A2U3Y279	A0A2U3YZU5	Bardet-Biedl syndrome 10 protein.	Bardet-Biedl syndrome 2 protein-like.	0.791
BBS10	CSF1	A0A2U3Y279	A0A2U3YQ02	Bardet-Biedl syndrome 10 protein.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.543
BBS10	TRIM32	A0A2U3Y279	A0A2U3YV19	Bardet-Biedl syndrome 10 protein.	E3 ubiquitin-protein ligase TRIM32-like isoform X1.	0.470
BBS2	BBS1	A0A2U3YZU5	A0A2U3YVJ8	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 1 protein.	0.999
BBS2	BBS10	A0A2U3YZU5	A0A2U3Y279	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 10 protein.	0.791
BBS2	SPATA7	A0A2U3YZU5	A0A2U3YEW7	Bardet-Biedl syndrome 2 protein-like.	LOW QUALITY PROTEIN: spermatogenesis-associated protein 7.	0.463
CD7	IL7	A0A2U3YA20	A0A2U3X7L8	T-cell antigen CD7.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.410
CLDN5	GPR116	A0A2U3Z8Q2	A0A2U3X856	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family.	0.512
CLDN5	LOC102748980	A0A2U3Z8Q2	A0A2U3Y5A5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein ZO-3-like.	0.636