STRINGSTRING
CD226 CD226 B2M B2M NCKAP1L NCKAP1L STAP1 STAP1 LOC102748638 LOC102748638 CLEC12B CLEC12B KLRK1 KLRK1 KLRF1 KLRF1 KLRB1 KLRB1 F2RL1 F2RL1 AGER AGER FADD FADD P2RX7 P2RX7 IL18RAP IL18RAP LAG3 LAG3 FAM49B FAM49B IL21 IL21 STAT5B STAT5B LOC102738001 LOC102738001 LOC102742806 LOC102742806 IL23A IL23A AP1G1 AP1G1 RASGRP1 RASGRP1 TYROBP TYROBP LEP LEP CRTAM CRTAM PVRL2 PVRL2 LOC102732650 LOC102732650 LOC102733853 LOC102733853 STX7 STX7 DNASE1L3 DNASE1L3 LOC102748045 LOC102748045 LOC102731864 LOC102731864 LOC102730741 LOC102730741
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD226CD226 antigen. (336 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
STAP1Signal-transducing adaptor protein 1. (332 aa)
LOC102748638Cell adhesion molecule 1-like. (249 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
KLRK1NKG2-D type II integral membrane protein. (216 aa)
KLRF1Killer cell lectin-like receptor subfamily F member 1. (237 aa)
KLRB1Killer cell lectin-like receptor subfamily B member 1. (250 aa)
F2RL1Proteinase-activated receptor 2. (415 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
IL18RAPInterleukin-18 receptor accessory protein. (593 aa)
LAG3Lymphocyte activation gene 3 protein. (389 aa)
FAM49BProtein FAM49B isoform X2. (324 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LOC102738001T-cell surface glycoprotein CD1a-like. (339 aa)
LOC102742806T-cell surface glycoprotein CD1b-like. (349 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (111 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
CRTAMCytotoxic and regulatory T-cell molecule. (366 aa)
PVRL2Poliovirus receptor-related protein 2. (539 aa)
LOC102732650SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
LOC102733853Antigen peptide transporter 2-like. (411 aa)
STX7Syntaxin-7; Belongs to the syntaxin family. (218 aa)
DNASE1L3Deoxyribonuclease gamma. (178 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102730741Natural killer cells antigen CD94-like. (162 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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