(56 nodes) Positive regulation of endothelial cell proliferation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDCL3	Phosducin-like protein 3. (239 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
	AGGF1	Angiogenic factor with G patch and FHA domains 1-like. (716 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	VIP	VIP peptides isoform X1. (170 aa)
	ZNF580	Zinc finger protein 580. (172 aa)
	NRARP	Notch-regulated ankyrin repeat-containing protein. (114 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (359 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
	NRAS	GTPase NRas. (189 aa)
	ITGA4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
	EGR3	Early growth response protein 3 isoform X1. (387 aa)
	LOC102739213	High mobility group protein B1-like. (214 aa)
	SP1	Transcription factor Sp1 isoform X1. (786 aa)
	FGFBP1	Fibroblast growth factor-binding protein 1. (255 aa)
	VASH2	Vasohibin-2 isoform X1. (355 aa)
	PDCD6	Programmed cell death protein 6 isoform X1. (189 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	EGFL7	Epidermal growth factor-like protein 7. (274 aa)
	BMP6	Bone morphogenetic protein 6. (189 aa)
	LRG1	Leucine-rich alpha-2-glycoprotein. (354 aa)
	LOC102736811	UPF0556 protein C19orf10 homolog. (173 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	LOC102737831	Serine/threonine-protein kinase D2-like. (246 aa)
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	SCG2	Secretogranin-2. (618 aa)
	LOC102749531	Growth/differentiation factor 2-like. (260 aa)
	EMC10	ER membrane protein complex subunit 10 isoform X1. (262 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	KIAA1462	Junctional protein associated with coronary artery disease-like. (1360 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
	NF1	Neurofibromin-like. (1269 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	LOC102736544	Thrombospondin-4-like. (685 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	LOC102736146	3-phosphoinositide-dependent protein kinase 1-like. (216 aa)
	LOC102732559	Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)
	ECM1	LOW QUALITY PROTEIN: extracellular matrix protein 1. (550 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	RNASE4	Ribonuclease 4 isoform X1; Belongs to the pancreatic ribonuclease family. (147 aa)
	PROK1	Prokineticin-1. (105 aa)
	CCL24	c-C motif chemokine 24. (119 aa)
	CCL26	C-C motif chemokine. (94 aa)
	IL10	Interleukin-10. (178 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (526 aa)
	CDH13	Cadherin-13-like. (512 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (852 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP2	A0A2U3YIM9	A0A2U3Z3S1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 2-like.	0.770
ACVRL1	BMP6	A0A2U3YIM9	A0A2U3YPC2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 6.	0.726
ACVRL1	BMPR2	A0A2U3YIM9	A0A2U3XT63	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.968
ACVRL1	LOC102740547	A0A2U3YIM9	A0A2U3Z034	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4-like isoform X1.	0.925
ACVRL1	LOC102749531	A0A2U3YIM9	A0A2U3YZP4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth/differentiation factor 2-like.	0.992
AKT1	AKT3	A0A2U3Y3V3	A0A2U3Y8K7	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.808
AKT1	JUN	A0A2U3Y3V3	A0A2U3Y748	Non-specific serine/threonine protein kinase.	Transcription factor AP-1; Belongs to the bZIP family.	0.873
AKT1	LOC102736146	A0A2U3Y3V3	A0A2U3Z6N9	Non-specific serine/threonine protein kinase.	3-phosphoinositide-dependent protein kinase 1-like.	0.955
AKT1	NF1	A0A2U3Y3V3	A0A2U3Z255	Non-specific serine/threonine protein kinase.	Neurofibromin-like.	0.409
AKT1	PIK3CD	A0A2U3Y3V3	A0A2U3YPT2	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.871
AKT3	AKT1	A0A2U3Y8K7	A0A2U3Y3V3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.808
AKT3	JUN	A0A2U3Y8K7	A0A2U3Y748	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transcription factor AP-1; Belongs to the bZIP family.	0.864
AKT3	LOC102736146	A0A2U3Y8K7	A0A2U3Z6N9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1-like.	0.974
AKT3	PIK3CD	A0A2U3Y8K7	A0A2U3YPT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.874
AKT3	STAT5A	A0A2U3Y8K7	A0A2U3Z446	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription 5A.	0.438
BMP2	ACVRL1	A0A2U3Z3S1	A0A2U3YIM9	Bone morphogenetic protein 2-like.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.770
BMP2	BMP6	A0A2U3Z3S1	A0A2U3YPC2	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 6.	0.924
BMP2	BMPR2	A0A2U3Z3S1	A0A2U3XT63	Bone morphogenetic protein 2-like.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.980
BMP2	FGF10	A0A2U3Z3S1	A0A2U3XE64	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.557
BMP2	FGF2	A0A2U3Z3S1	A0A2U3Z312	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.722