(27 nodes) Heart looping network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CITED2	Cbp/p300-interacting transactivator 2. (271 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (1238 aa)
	ASB2	Ankyrin repeat and SOCS box protein 2. (630 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (429 aa)
	MICAL2	Protein-methionine sulfoxide oxidase MICAL2. (88 aa)
	FOXH1	Forkhead box protein H1. (360 aa)
	NODAL	Nodal homolog. (348 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	HAND1	Heart- and neural crest derivatives-expressed protein 1. (218 aa)
	LOC102746003	Clusterin-associated protein 1-like. (216 aa)
	SOX17	Transcription factor SOX-17-like. (406 aa)
	ZIC3	Zinc finger protein ZIC 3. (465 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (625 aa)
	TBX3	T-box transcription factor TBX3. (675 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (823 aa)
	SRF	Serum response factor. (508 aa)
	LOC102731974	Coiled-coil domain-containing protein 103-like. (242 aa)
	TBX20	T-box transcription factor TBX20. (447 aa)
	TBX6	T-box transcription factor TBX6. (436 aa)
	LOC102731945	Suppressor of fused homolog. (106 aa)
	ARL13B	ADP-ribosylation factor-like protein 13B isoform X1. (430 aa)
	PKD2	Polycystin-2. (935 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	LOC102727186	Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
	SHH	Sonic hedgehog protein-like. (286 aa)
	LOC102732559	Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	IFT57	A0A2U3XAZ2	A0A2U3YVR2	ADP-ribosylation factor-like protein 13B isoform X1.	Intraflagellar transport protein 57 homolog.	0.695
ARL13B	LOC102731945	A0A2U3XAZ2	A0A2U3XI49	ADP-ribosylation factor-like protein 13B isoform X1.	Suppressor of fused homolog.	0.475
ARL13B	PKD2	A0A2U3XAZ2	A0A2U3X6P6	ADP-ribosylation factor-like protein 13B isoform X1.	Polycystin-2.	0.793
ARL13B	SHH	A0A2U3XAZ2	A0A2U3Z6V6	ADP-ribosylation factor-like protein 13B isoform X1.	Sonic hedgehog protein-like.	0.715
CITED2	HIF1A	A0A2U3YZF2	A0A2U3Y4G5	Cbp/p300-interacting transactivator 2.	Hypoxia-inducible factor 1-alpha isoform X1.	0.501
DLL1	NOTCH2	A0A2U3YLU9	A0A2U3YXQ8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2.	0.979
DNAAF1	LOC102731974	A0A2U3Y825	A0A2U3XX13	Dynein assembly factor 1, axonemal.	Coiled-coil domain-containing protein 103-like.	0.774
FOXH1	LOC102730318	A0A2U3YRK2	A0A2U3Z2G6	Forkhead box protein H1.	Mothers against decapentaplegic homolog.	0.859
FOXH1	NODAL	A0A2U3YRK2	A0A2U3YPZ3	Forkhead box protein H1.	Nodal homolog.	0.507
FOXH1	ZIC3	A0A2U3YRK2	A0A2U3YE89	Forkhead box protein H1.	Zinc finger protein ZIC 3.	0.402
HIF1A	CITED2	A0A2U3Y4G5	A0A2U3YZF2	Hypoxia-inducible factor 1-alpha isoform X1.	Cbp/p300-interacting transactivator 2.	0.501
HIF1A	LOC102730318	A0A2U3Y4G5	A0A2U3Z2G6	Hypoxia-inducible factor 1-alpha isoform X1.	Mothers against decapentaplegic homolog.	0.724
IFT57	ARL13B	A0A2U3YVR2	A0A2U3XAZ2	Intraflagellar transport protein 57 homolog.	ADP-ribosylation factor-like protein 13B isoform X1.	0.695
IFT57	LOC102731945	A0A2U3YVR2	A0A2U3XI49	Intraflagellar transport protein 57 homolog.	Suppressor of fused homolog.	0.574
IFT57	LOC102746003	A0A2U3YVR2	A0A2U3YH96	Intraflagellar transport protein 57 homolog.	Clusterin-associated protein 1-like.	0.998
LOC102727186	MEF2C	A0A2U3Z5T9	A0A2U3YMC3	Heart- and neural crest derivatives-expressed protein 2-like.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.635
LOC102727186	TBX20	A0A2U3Z5T9	A0A2U3XRT2	Heart- and neural crest derivatives-expressed protein 2-like.	T-box transcription factor TBX20.	0.569
LOC102730318	FOXH1	A0A2U3Z2G6	A0A2U3YRK2	Mothers against decapentaplegic homolog.	Forkhead box protein H1.	0.859
LOC102730318	HIF1A	A0A2U3Z2G6	A0A2U3Y4G5	Mothers against decapentaplegic homolog.	Hypoxia-inducible factor 1-alpha isoform X1.	0.724
LOC102730318	MEF2C	A0A2U3Z2G6	A0A2U3YMC3	Mothers against decapentaplegic homolog.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.559