137 items (Leptonychotes weddellii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK2	Tyrosine-protein kinase. (952 aa)
	IL18R1	Interleukin-18 receptor 1. (540 aa)
	KLHL6	Kelch-like protein 6. (621 aa)
	CD79B	B-cell antigen receptor complex-associated protein beta chain isoform X1. (222 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	C1S	Complement C1s subcomponent isoform X1; Belongs to the peptidase S1 family. (695 aa)
	C1R	Complement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (705 aa)
	C8A	Complement component C8 alpha chain. (589 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	TAP1	Antigen peptide transporter 1. (750 aa)
	LOC102747485	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2. (329 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	C1QB	Complement C1q subcomponent subunit B. (249 aa)
	C1QC	Complement C1q subcomponent subunit C. (245 aa)
	ZP2	Zona pellucida sperm-binding protein 2. (715 aa)
	TFE3	Transcription factor E3 isoform X1. (571 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	ARG2	Arginase. (354 aa)
	ERCC1	DNA excision repair protein ERCC-1. (293 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	CD7	T-cell antigen CD7. (209 aa)
	LIG4	DNA ligase. (911 aa)
	TEC	Tyrosine-protein kinase. (630 aa)
	BCL10	B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain. (213 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	ENTPD7	Ectonucleoside triphosphate diphosphohydrolase 7-like; Belongs to the GDA1/CD39 NTPase family. (413 aa)
	LOC102739213	High mobility group protein B1-like. (214 aa)
	LOC102730162	T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
	LOC102734398	T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (472 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)
	IRF7	Interferon regulatory factor 7. (470 aa)
	CSF2RB	Cytokine receptor common subunit beta. (902 aa)
	RFTN1	Raftlin. (347 aa)
	C9	Complement component C9. (217 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)
	BATF	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (312 aa)
	FCER1G	High affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	CARD9	Caspase recruitment domain-containing protein 9-like. (536 aa)
	HLX	H2.0-like homeobox protein. (415 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	IFNE	Interferon epsilon. (208 aa)
	IL18BP	Interleukin-18-binding protein. (188 aa)
	CTSH	Pro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
	AKIRIN2	Akirin-2. (115 aa)
	TNFRSF14	Tumor necrosis factor receptor superfamily member 14. (272 aa)
	LOC102745401	Venom factor-like. (218 aa)
	LOC102748902	Complement C3-like. (383 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
	IL21R	Interleukin-21 receptor. (542 aa)
	HCK	Tyrosine-protein kinase. (504 aa)
	PRF1	Perforin-1. (555 aa)
	EXOSC6	Exosome complex component MTR3. (195 aa)
	EXO1	LOW QUALITY PROTEIN: exonuclease 1. (793 aa)
	LOC102737749	Transcription factor RelB-like. (167 aa)
	BCL3	B-cell lymphoma 3 protein. (407 aa)
	UNC13D	Protein unc-13 homolog D. (1091 aa)
	IL17A	interleukin-17A. (155 aa)
	LOC102732650	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (797 aa)
	JAK3	Tyrosine-protein kinase. (1139 aa)
	LOC102740348	Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
	LOC102732741	uracil-DNA glycosylase-like. (177 aa)
	LOC102733853	Antigen peptide transporter 2-like. (411 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	MATK	Tyrosine-protein kinase. (496 aa)
	LOC102747745	Interleukin-9 receptor-like. (175 aa)
	RAB44	Ras-related protein Rab-44. (795 aa)
	LOC102725972	Cytoplasmic tyrosine-protein kinase BMX-like. (151 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	LOC102748833	Tyrosine-protein kinase. (375 aa)
	LOC102737563	Complement C5-like. (186 aa)
	LOC102749847	Tyrosine-protein kinase JAK1-like. (444 aa)
	SEMA4A	semaphorin-4A-like. (350 aa)
	LOC102730741	Natural killer cells antigen CD94-like. (162 aa)
	IFNA14	LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
	FGB	Fibrinogen beta chain isoform X1. (484 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21 isoform X1. (651 aa)
	MARCH8	E3 ubiquitin-protein ligase MARCH8. (569 aa)
	SWAP70	Switch-associated protein 70 isoform X1. (585 aa)
	EXOSC3	Exosome complex component RRP40 isoform X1. (275 aa)
	IGJ	Immunoglobulin J chain isoform X1. (158 aa)
	FCAMR	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor. (524 aa)
	ITK	Tyrosine-protein kinase. (486 aa)
	LAX1	LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (432 aa)
	RAB27A	Ras-related protein Rab-27A. (221 aa)
	CD79A	B-cell antigen receptor complex-associated protein alpha chain isoform X1. (236 aa)
	KLRK1	NKG2-D type II integral membrane protein. (216 aa)
	LOC102747757	Interferon alpha-1/2-like. (187 aa)
	LOC102750324	Interferon alpha-2-like. (175 aa)
	IFNB1	Interferon beta. (182 aa)
	KIAA1841	Uncharacterized protein KIAA1841 homolog. (718 aa)
	ERAP2	Aminopeptidase. (952 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	CLEC4G	C-type lectin domain family 4 member G. (293 aa)
	LOC102728215	Complement C3-like. (768 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	ZP3	Zona pellucida sperm-binding protein 3. (427 aa)
	CD19	B-lymphocyte antigen CD19. (559 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	FRK	Tyrosine-protein kinase. (515 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	TRAF3IP2	Adapter protein CIKS isoform X1. (563 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	MASP2	LOW QUALITY PROTEIN: mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family. (722 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (166 aa)
	LOC102737884	Tyrosine-protein kinase. (539 aa)
	C2	Complement C2 isoform X1; Belongs to the peptidase S1 family. (748 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	C5	Complement C5. (1391 aa)
	MYO1G	Unconventional myosin-Ig isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	LOC102730452	semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
	LOC102738400	Annexin. (345 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (951 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
	IFNK	Interferon kappa. (208 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG2	CD4	A0A2U3Y4M4	A0A2U3Y2Q1	Arginase.	T-cell surface glycoprotein CD4.	0.568
ARG2	IL6	A0A2U3Y4M4	A0A2U3YGL7	Arginase.	Interleukin-6 isoform X1.	0.544
B2M	CD247	A0A2U3X7R0	A0A2U3XW81	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD3 zeta chain.	0.502
B2M	CD3D	A0A2U3X7R0	A0A2U3YDJ4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD3 delta chain.	0.431
B2M	CD4	A0A2U3X7R0	A0A2U3Y2Q1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD4.	0.401
B2M	CD8A	A0A2U3X7R0	A0A2U3YBZ1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD8 alpha chain.	0.811
B2M	ERCC1	A0A2U3X7R0	A0A2U3Y4P3	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA excision repair protein ERCC-1.	0.612
B2M	EXO1	A0A2U3X7R0	A0A2U3YW79	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	LOW QUALITY PROTEIN: exonuclease 1.	0.611
B2M	LIG4	A0A2U3X7R0	A0A2U3YB17	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA ligase.	0.569
B2M	LOC102730741	A0A2U3X7R0	A0A2U3Z8F5	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94-like.	0.473
B2M	LOC102732741	A0A2U3X7R0	A0A2U3Z2A1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	uracil-DNA glycosylase-like.	0.581
B2M	LOC102734456	A0A2U3X7R0	A0A2U3Z2X5	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.567
B2M	LOC102740784	A0A2U3X7R0	A0A2U3XXW2	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.592
B2M	LOC102741082	A0A2U3X7R0	A0A2U3XXW7	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.600
B2M	LOC102747485	A0A2U3X7R0	A0A2U3Y330	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2.	0.600
B2M	LOC102748462	A0A2U3X7R0	A0A2U3Y332	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO beta chain-like.	0.600
B2M	LOC102750166	A0A2U3X7R0	A0A2U3Y3B4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM beta chain-like.	0.597
B2M	LOC102750454	A0A2U3X7R0	A0A2U3Y337	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.540
B2M	MSH2	A0A2U3X7R0	A0A2U3XZS6	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.640
B2M	MSH6	A0A2U3X7R0	A0A2U3XZI8	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.739