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LOC102742605 LOC102742605 TADA2A TADA2A LOC102738874 LOC102738874 LOC102748752 LOC102748752 LOC102740375 LOC102740375 LOC102750433 LOC102750433 LOC102729516 LOC102729516 LOC102740668 LOC102740668 LOC102726388 LOC102726388 MMS19 MMS19 LOC102750134 LOC102750134 MID2 MID2 LOC102749930 LOC102749930 LOC102727383 LOC102727383 LOC102739775 LOC102739775 POU2AF1 POU2AF1 PRMT2 PRMT2 LOC102746959 LOC102746959 FGF2 FGF2 LOC102731237 LOC102731237 LOC102747634 LOC102747634 LOC102744093 LOC102744093 CCDC124 CCDC124 TCF20 TCF20 LOC102731337 LOC102731337 BCL9L BCL9L CITED2 CITED2 ABL1 ABL1 LOC102732536 LOC102732536 ARL2BP ARL2BP BCL3 BCL3 LOC102741543 LOC102741543 NCOA7 NCOA7 SS18L2 SS18L2 LOC102743143 LOC102743143 RBM14 RBM14 YAP1 YAP1 LOC102744478 LOC102744478 USP21 USP21 TRIM32 TRIM32 PARK7 PARK7 DYRK1A DYRK1A MED1 MED1 CREBBP CREBBP MED12L MED12L PSMD9 PSMD9 PPARGC1A PPARGC1A SS18 SS18 LOC102738225 LOC102738225 HMGA1 HMGA1 MED13 MED13 LOC102728667 LOC102728667 NCOA3 NCOA3 JUP JUP MECOM MECOM NPAT NPAT UBE2L3 UBE2L3 SERTAD1 SERTAD1 DYRK1B DYRK1B CAMTA2 CAMTA2 TRIM14 TRIM14 USP16 USP16 MYCBP MYCBP WWC1 WWC1 LMO1 LMO1 CENPJ CENPJ ZIC3 ZIC3 CBFB CBFB NCOA1 NCOA1 LOC102739213 LOC102739213 CCAR2 CCAR2 TADA1 TADA1 SLC30A9 SLC30A9 BCL10 BCL10 MED16 MED16 MED4 MED4 CITED1 CITED1 ETS1 ETS1 TRIM24 TRIM24 LOC102731796 LOC102731796 TAF5L TAF5L MAML1 MAML1 TAF12 TAF12 MAK MAK ACTN4 ACTN4 TADA3 TADA3 GPS2 GPS2 ATXN7L3 ATXN7L3 KAT2A KAT2A CDCA4 CDCA4 LOC102750059 LOC102750059 ACTN2 ACTN2 TOX3 TOX3 PKN1 PKN1 MED21 MED21 ANKRD1 ANKRD1 ACRBP ACRBP ING4 ING4 RUVBL1 RUVBL1 KDM1A KDM1A MED12 MED12 LOC102745156 LOC102745156 SUB1 SUB1 TRIM13 TRIM13 LOC102727215 LOC102727215 TAF11 TAF11 NUCKS1 NUCKS1 LOC102751229 LOC102751229 LOC102750159 LOC102750159 PMF1 PMF1 THRAP3 THRAP3 SMARCA2 SMARCA2 ZMIZ2 ZMIZ2 TMF1 TMF1 TADA2B TADA2B ACTN1 ACTN1 HIPK2 HIPK2 DCAF6 DCAF6 NRIP1 NRIP1 LOC102745454 LOC102745454 YAF2 YAF2 ZMIZ1 ZMIZ1 TRIP4 TRIP4 LOC102744942 LOC102744942 MED6 MED6 SUPT3H SUPT3H IRF4 IRF4 MED30 MED30 NUPR1 NUPR1 TAF6 TAF6 LOC102728823 LOC102728823 WWTR1 WWTR1 LOC102741366 LOC102741366 MCIDAS MCIDAS TRIM21 TRIM21 TACC1 TACC1 SRA1 SRA1 APEX1 APEX1 PPRC1 PPRC1 TRIM8 TRIM8 MTA2 MTA2 KAT2B KAT2B EP300 EP300 MKL1 MKL1 NUPR1L NUPR1L FUS FUS KAT8 KAT8 UBE3A UBE3A TDRD3 TDRD3 DHX9 DHX9 KMT2D KMT2D CCAR1 CCAR1 CALCOCO1 CALCOCO1 LPIN2 LPIN2 LOC102749903 LOC102749903 RNF20 RNF20 FHL5 FHL5 NCOA6 NCOA6 JADE1 JADE1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC102742605Nascent polypeptide-associated complex subunit alpha-like isoform X2. (215 aa)
TADA2ALOW QUALITY PROTEIN: transcriptional adaptor 2A. (306 aa)
LOC102738874Host cell factor 1-like. (1151 aa)
LOC102748752Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (186 aa)
LOC102740375Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (149 aa)
LOC102750433Histone-lysine N-methyltransferase setd3-like. (117 aa)
LOC102729516Mastermind-like protein 2-like. (421 aa)
LOC102740668RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (335 aa)
LOC102726388Calcium-binding and coiled-coil domain-containing protein 1-like. (437 aa)
MMS19MMS19 nucleotide excision repair protein homolog. (665 aa)
LOC102750134Nuclear pore complex protein Nup98-Nup96-like. (225 aa)
MID2Probable E3 ubiquitin-protein ligase MID2-like isoform X2. (461 aa)
LOC102749930AT-rich interactive domain-containing protein 5B-like. (216 aa)
LOC102727383Rhombotin-1-like. (79 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
POU2AF1POU domain class 2-associating factor 1. (286 aa)
PRMT2Protein arginine N-methyltransferase 2-like isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa)
LOC102746959LIM domain transcription factor LMO4-like isoform X1. (165 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102731237SNW domain-containing protein 1-like. (340 aa)
LOC102747634Protein WWC3-like. (187 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
CCDC124Coiled-coil domain-containing protein 124 isoform X1. (223 aa)
TCF20Transcription factor 20 isoform X1. (1957 aa)
LOC102731337Protein-histidine N-methyltransferase. (244 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X1. (1495 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
LOC102732536DNA repair protein complementing XP-C cells-like. (544 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (163 aa)
BCL3B-cell lymphoma 3 protein. (407 aa)
LOC102741543Zinc finger protein ZFPM2-like. (827 aa)
NCOA7Nuclear receptor coactivator 7-like isoform X1. (943 aa)
SS18L2SS18-like protein 2. (77 aa)
LOC102743143Zinc finger protein ZXDC-like. (110 aa)
RBM14RNA-binding protein 14 isoform X1. (669 aa)
YAP1Yorkie homolog. (326 aa)
LOC102744478Niban-like protein 1-like. (374 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32-like isoform X1. (655 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A-like isoform X1. (762 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
CREBBPCREB-binding protein-like. (1411 aa)
MED12LMediator of RNA polymerase II transcription subunit 12-like protein-like isoform X1. (768 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
SS18Protein SSXT isoform X1. (418 aa)
LOC102738225Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (117 aa)
HMGA1High mobility group protein HMG-I/HMG-Y isoform X1. (107 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (904 aa)
LOC102728667Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
NCOA3Nuclear receptor coactivator 3-like. (1154 aa)
JUPJunction plakoglobin. (307 aa)
MECOMMDS1 and EVI1 complex locus protein MDS1. (125 aa)
NPATProtein NPAT. (1447 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
SERTAD1SERTA domain-containing protein 1 isoform X1. (237 aa)
DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2. (629 aa)
CAMTA2Calmodulin-binding transcription activator 2 isoform X4. (1196 aa)
TRIM14Tripartite motif-containing protein 14. (285 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (825 aa)
MYCBPc-Myc-binding protein. (103 aa)
WWC1Protein KIBRA. (967 aa)
LMO1Rhombotin-1. (76 aa)
CENPJCentromere protein J. (1354 aa)
ZIC3Zinc finger protein ZIC 3. (465 aa)
CBFBCore-binding factor subunit beta isoform X1. (187 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
CCAR2Cell cycle and apoptosis regulator protein 2. (918 aa)
TADA1Transcriptional adapter 1. (335 aa)
SLC30A9Zinc transporter 9. (578 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (664 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
LOC102731796Dr1-associated corepressor-like isoform X1. (212 aa)
TAF5Lannotation not available (589 aa)
MAML1Mastermind-like protein 1. (948 aa)
TAF12Transcription initiation factor TFIID subunit 12 isoform X1. (161 aa)
MAKSerine/threonine-protein kinase MAK isoform X1. (649 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
TADA3Transcriptional adapter 3 isoform X1. (432 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (354 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
CDCA4Cell division cycle-associated protein 4. (242 aa)
LOC102750059Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (863 aa)
ACTN2Alpha-actinin-2 isoform X1. (894 aa)
TOX3TOX high mobility group box family member 3-like isoform X1. (567 aa)
PKN1Serine/threonine-protein kinase N1. (796 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
ACRBPAcrosin-binding protein. (535 aa)
ING4Inhibitor of growth protein. (249 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (175 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (812 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
SUB1Activated RNA polymerase II transcriptional coactivator p15 isoform X1. (126 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13. (407 aa)
LOC102727215Niban-like protein 1-like. (398 aa)
TAF11Transcription initiation factor TFIID subunit 11 isoform X1. (211 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1. (243 aa)
LOC102751229Zinc finger protein RFP-like isoform X1. (513 aa)
LOC102750159Junction plakoglobin-like. (503 aa)
PMF1Polyamine-modulated factor 1. (205 aa)
THRAP3Thyroid hormone receptor-associated protein 3 isoform X2. (957 aa)
SMARCA2Probable global transcription activator SNF2L2 isoform X1. (278 aa)
ZMIZ2Zinc finger MIZ domain-containing protein 2 isoform X1. (919 aa)
TMF1TATA element modulatory factor. (1089 aa)
TADA2BTranscriptional adapter. (420 aa)
ACTN1Alpha-actinin-1. (406 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
DCAF6DDB1- and CUL4-associated factor 6 isoform X1. (950 aa)
NRIP1Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)
LOC102745454Nuclear receptor coactivator 3-like. (176 aa)
YAF2YY1-associated factor 2 isoform X2. (204 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (957 aa)
TRIP4Activating signal cointegrator 1. (581 aa)
LOC102744942Arginine-glutamic acid dipeptide repeats protein-like. (996 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (246 aa)
SUPT3HTranscription initiation protein SPT3 homolog. (377 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
MED30Mediator of RNA polymerase II transcription subunit 30 isoform X1. (178 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
TAF6Transcription initiation factor TFIID subunit 6 isoform X1. (677 aa)
LOC102728823Ubiquitin-conjugating enzyme E2 L3-like isoform X1. (153 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
LOC102741366Methylosome protein 50-like. (169 aa)
MCIDASMulticilin. (384 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
TACC1Transforming acidic coiled-coil-containing protein 1. (607 aa)
SRA1Steroid receptor RNA activator 1 isoform X2. (225 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
PPRC1Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1. (1661 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (551 aa)
MTA2Metastasis-associated protein MTA2 isoform X1. (668 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
EP300Histone acetyltransferase p300. (2425 aa)
MKL1MKL/myocardin-like protein 1 isoform X1. (956 aa)
NUPR1LNuclear transcriptional regulator 1-like protein. (98 aa)
FUSRNA-binding protein FUS isoform X1. (517 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
TDRD3Tudor domain-containing protein 3-like isoform X1. (651 aa)
DHX9ATP-dependent RNA helicase A. (1276 aa)
KMT2DHistone-lysine N-methyltransferase 2D. (5552 aa)
CCAR1Cell division cycle and apoptosis regulator protein 1 isoform X2. (1150 aa)
CALCOCO1Calcium-binding and coiled-coil domain-containing protein 1. (292 aa)
LPIN2Phosphatidate phosphatase LPIN2. (937 aa)
LOC102749903Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
FHL5Four and a half LIM domains protein 5. (284 aa)
NCOA6Nuclear receptor coactivator 6 isoform X1. (2046 aa)
JADE1Protein Jade-1 isoform X1. (843 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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