STRINGSTRING
LHX1 LHX1 DVL1 DVL1 LOC102725595 LOC102725595 UGDH UGDH AXIN1 AXIN1 RNF2 RNF2 MSGN1 MSGN1 COL7A1 COL7A1 GATA6 GATA6 LEO1 LEO1 SOX7 SOX7 TBX6 TBX6 ITGB3 ITGB3 NR0B1 NR0B1 BMPR2 BMPR2 SMAD4 SMAD4 TLX2 TLX2 SRF SRF SYF2 SYF2 ITGB1 ITGB1 HNF1A HNF1A ATOH8 ATOH8 DUSP1 DUSP1 NANOG NANOG TP53 TP53 DVL2 DVL2 KDM6B KDM6B LOC102741200 LOC102741200 BMPR1A BMPR1A EOMES EOMES LOC102730470 LOC102730470 MESP2 MESP2 ITGA4 ITGA4 RIC8A RIC8A PRKAR1A PRKAR1A ZIC3 ZIC3 SOX17 SOX17 COL8A1 COL8A1 TWSG1 TWSG1 ETV2 ETV2 WNT11 WNT11 PAF1 PAF1 WNT3A WNT3A EYA1 EYA1 WNT3 WNT3 LOC102728858 LOC102728858 ARFRP1 ARFRP1 MIXL1 MIXL1 SMAD1 SMAD1 HAND1 HAND1 FOXF1 FOXF1 CER1 CER1 NODAL NODAL COL6A1 COL6A1 GNB2L1 GNB2L1 MMP14 MMP14 SFRP1 SFRP1 INHBA INHBA TENM4 TENM4 MEGF8 MEGF8 LOC102726972 LOC102726972 LOC102740547 LOC102740547 LOC102727681 LOC102727681 LOC102730318 LOC102730318 LOC102746660 LOC102746660 LOC102731544 LOC102731544 LOC102738369 LOC102738369 MMP8 MMP8 LOC102750898 LOC102750898 LOC102732559 LOC102732559 POGLUT1 POGLUT1 DKK2 DKK2 LEF1 LEF1 SFRP2 SFRP2 LOC102739837 LOC102739837 CTR9 CTR9 ITGA5 ITGA5 ITGA7 ITGA7 EXOC4 EXOC4 NOG NOG ARMC5 ARMC5 SNAI1 SNAI1 VTN VTN HOXA11 HOXA11 HMGA2 HMGA2 LOC102732851 LOC102732851 LOC102726171 LOC102726171 LOC102726169 LOC102726169 T T
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX1LIM/homeobox protein Lhx1. (406 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
LOC102725595Fibroblast growth factor receptor substrate 2-like. (316 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
AXIN1Axin-1 isoform X1. (867 aa)
RNF2E3 ubiquitin-protein ligase RING2 isoform X1. (336 aa)
MSGN1Mesogenin-1. (193 aa)
COL7A1Collagen alpha-1(VII) chain-like. (532 aa)
GATA6Transcription factor GATA-6. (287 aa)
LEO1RNA polymerase-associated protein LEO1. (570 aa)
SOX7Transcription factor SOX-7. (386 aa)
TBX6T-box transcription factor TBX6. (436 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (393 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TLX2T-cell leukemia homeobox protein 2. (284 aa)
SRFSerum response factor. (508 aa)
SYF2pre-mRNA-splicing factor SYF2. (246 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (631 aa)
ATOH8Protein atonal homolog 8. (318 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
NANOGHomeobox protein NANOG. (226 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
KDM6BLysine-specific demethylase 6B. (1559 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EOMESEomesodermin homolog isoform X2. (571 aa)
LOC102730470Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
MESP2Mesoderm posterior protein 2. (178 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
RIC8Asynembryn-A isoform X2. (529 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
ZIC3Zinc finger protein ZIC 3. (465 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
COL8A1Collagen alpha-1(VIII) chain isoform X1. (744 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
ETV2ETS translocation variant 2 isoform X1. (340 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X2. (528 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
LOC102728858Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family. (251 aa)
ARFRP1ADP-ribosylation factor-related protein 1 isoform X1. (201 aa)
MIXL1Homeobox protein MIXL1. (124 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
FOXF1Forkhead box protein F1. (427 aa)
CER1Cerberus. (274 aa)
NODALNodal homolog. (348 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
INHBAInhibin beta A chain. (424 aa)
TENM4Teneurin-4. (1083 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2068 aa)
LOC102726972T-box transcription factor TBX19-like. (173 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102727681Exostosin-2-like. (142 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102746660RNA polymerase-associated protein CTR9 homolog. (452 aa)
LOC102731544Collagen alpha-1(VII) chain-like. (2351 aa)
LOC102738369Merlin-like. (110 aa)
MMP8Neutrophil collagenase. (400 aa)
LOC102750898T-box transcription factor TBX19-like. (148 aa)
LOC102732559Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
DKK2Dickkopf-related protein 2. (259 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
LOC102739837Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
CTR9RNA polymerase-associated protein CTR9 homolog. (723 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ITGA7Integrin alpha-7; Belongs to the integrin alpha chain family. (1181 aa)
EXOC4Exocyst complex component 4. (408 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
VTNVitronectin. (456 aa)
HOXA11Homeobox protein Hox-A11. (321 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
LOC102732851LIM domain-binding protein 1-like. (227 aa)
LOC102726171LIM domain-binding protein 1-like. (190 aa)
LOC102726169Transcription factor SPT20 homolog. (808 aa)
TBrachyury protein isoform X1. (435 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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