STRINGSTRING
CNTN1 CNTN1 DLX2 DLX2 LOC102736999 LOC102736999 IFNG IFNG AKT3 AKT3 STAT3 STAT3 NCSTN NCSTN LOC102741358 LOC102741358 LOC102749048 LOC102749048 CDK5 CDK5 LOC102744935 LOC102744935 LOC102729428 LOC102729428 LOC102734263 LOC102734263 GPR37L1 GPR37L1 SIRT2 SIRT2 LOC102741496 LOC102741496 NTRK2 NTRK2 LOC102747093 LOC102747093 SOX8 SOX8 ERCC2 ERCC2 LOC102745161 LOC102745161 AKT1 AKT1 EIF2B5 EIF2B5 NKX6-1 NKX6-1 MED12 MED12 PRDM8 PRDM8 CNTN2 CNTN2 MYOC MYOC AGER AGER GFAP GFAP LOC102748855 LOC102748855 PTPN11 PTPN11 MTOR MTOR EGR2 EGR2 GBA GBA LOC102731565 LOC102731565 GPR157 GPR157 MPP5 MPP5 CRB1 CRB1 TRPC4 TRPC4 LOC102748544 LOC102748544 NKX2-2 NKX2-2 PTEN PTEN ILK ILK MXRA8 MXRA8 DLX1 DLX1 VTN VTN LOC102741862 LOC102741862 MYRF MYRF PPP3R1 PPP3R1 FGF10 FGF10 NR2E1 NR2E1 LOC102741936 LOC102741936 TREM2 TREM2 PAX6 PAX6 EIF2B3 EIF2B3 ERBB3 ERBB3 LOC102729094 LOC102729094 CNTF CNTF EMX1 EMX1 LOC102732823 LOC102732823 S100B S100B KRAS KRAS LEF1 LEF1 BMP2 BMP2 S100A9 S100A9 EIF2B4 EIF2B4 FGF2 FGF2 LAMB2 LAMB2 NF1 NF1 LOC102738254 LOC102738254 NAB2 NAB2 LOC102731633 LOC102731633 ABL1 ABL1 LOC102742457 LOC102742457 LOC102732425 LOC102732425 SOX10 SOX10 TENM4 TENM4 POU3F1 POU3F1 EIF2B2 EIF2B2 LOC102727345 LOC102727345 TPPP TPPP DLL1 DLL1 DAG1 DAG1 LOC102749599 LOC102749599 FA2H FA2H CNP CNP NKX6-2 NKX6-2 METTL14 METTL14 MAPK1 MAPK1 KCNJ10 KCNJ10 PRX PRX WASF3 WASF3 NRROS NRROS NKX2-1 NKX2-1 PHOX2B PHOX2B DNER DNER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTN1Contactin-1-like isoform X1. (1018 aa)
DLX2Homeobox protein DLX-2. (330 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
NCSTNNicastrin. (602 aa)
LOC102741358Protein S100; Belongs to the S-100 family. (89 aa)
LOC102749048Myelin proteolipid protein-like isoform X1. (277 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
LOC102744935Translation initiation factor eIF-2B subunit alpha-like; Belongs to the eIF-2B alpha/beta/delta subunits family. (75 aa)
LOC102729428Translation initiation factor eIF-2B subunit alpha-like; Belongs to the eIF-2B alpha/beta/delta subunits family. (114 aa)
LOC102734263Translation initiation factor eIF-2B subunit alpha-like; Belongs to the eIF-2B alpha/beta/delta subunits family. (142 aa)
GPR37L1Prosaposin receptor GPR37L1. (477 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LOC102741496BDNF/NT-3 growth factors receptor-like. (97 aa)
NTRK2BDNF/NT-3 growth factors receptor-like. (420 aa)
LOC102747093Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (115 aa)
SOX8Transcription factor SOX-8. (412 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (661 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
EIF2B5Translation initiation factor eIF-2B subunit epsilon. (718 aa)
NKX6-1Homeobox protein Nkx-6.1-like. (366 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (812 aa)
PRDM8PR domain zinc finger protein 8. (470 aa)
CNTN2Contactin-2. (903 aa)
MYOCMyocilin. (490 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (432 aa)
LOC102748855Delta and Notch-like epidermal growth factor-related receptor-like. (297 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
GBAGlucosylceramidase. (536 aa)
LOC102731565Laminin subunit gamma-3-like. (231 aa)
GPR157LOW QUALITY PROTEIN: probable G-protein coupled receptor 157. (328 aa)
MPP5MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1406 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
LOC102748544Protein NDRG1-like. (142 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
MXRA8Matrix-remodeling-associated protein 8. (347 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
VTNVitronectin. (456 aa)
LOC102741862Leucine-rich repeat LGI family member 4-like. (226 aa)
MYRFMyelin regulatory factor. (604 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
PAX6Paired box protein Pax-6. (221 aa)
EIF2B3Translation initiation factor eIF-2B subunit gamma. (451 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
LOC102729094Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (106 aa)
CNTFCiliary neurotrophic factor. (199 aa)
EMX1Homeobox protein EMX1. (295 aa)
LOC102732823Vimentin-like isoform X1; Belongs to the intermediate filament family. (466 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
KRASGTPase KRas isoform X2. (188 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
S100A9Protein S100; Belongs to the S-100 family. (140 aa)
EIF2B4Translation initiation factor eIF-2B subunit delta isoform X1; Belongs to the eIF-2B alpha/beta/delta subunits family. (544 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
NF1Neurofibromin-like. (1269 aa)
LOC102738254Vimentin-like; Belongs to the intermediate filament family. (209 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
LOC102731633Rho guanine nucleotide exchange factor 10-like. (410 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
LOC102742457D-3-phosphoglycerate dehydrogenase-like; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (215 aa)
LOC102732425Myelin-associated glycoprotein-like. (382 aa)
SOX10Transcription factor SOX-10. (469 aa)
TENM4Teneurin-4. (1083 aa)
POU3F1POU domain protein. (261 aa)
EIF2B2Translation initiation factor eIF-2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
TPPPTubulin polymerization-promoting protein. (221 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
DAG1Dystroglycan isoform X1. (891 aa)
LOC102749599Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
NKX6-2Homeobox protein Nkx-6.2. (168 aa)
METTL14Methyltransferase-like protein 14; Belongs to the MT-A70-like family. (456 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
PRXPeriaxin. (844 aa)
WASF3wiskott-Aldrich syndrome protein family member 3-like. (328 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
DNERDelta and Notch-like epidermal growth factor-related receptor. (448 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.