STRINGSTRING
ZNF580 ZNF580 LOC102750030 LOC102750030 LOC102736354 LOC102736354 LOC102730129 LOC102730129 LOC102726881 LOC102726881 LOC102736146 LOC102736146 LOC102744822 LOC102744822 LOC102741867 LOC102741867 STAT5A STAT5A LOC102734950 LOC102734950 AGT AGT AAMP AAMP FGF2 FGF2 LOC102730108 LOC102730108 LOC102738856 LOC102738856 LOC102740057 LOC102740057 SASH1 SASH1 INSL3 INSL3 KIAA1462 KIAA1462 LOC102740547 LOC102740547 EMC10 EMC10 VIL1 VIL1 ABL1 ABL1 FUT1 FUT1 TGFB1 TGFB1 PDGFB PDGFB MAP2K3 MAP2K3 LOC102737831 LOC102737831 ANGPT4 ANGPT4 CTSH CTSH PIK3CD PIK3CD ENPP2 ENPP2 FGF18 FGF18 RHOJ RHOJ LOC102727345 LOC102727345 LOC102725841 LOC102725841 RRAS RRAS LOC102735415 LOC102735415 SRPX2 SRPX2 PPM1F PPM1F LOC102746002 LOC102746002 PDCD6 PDCD6 THBS1 THBS1 FGFBP1 FGFBP1 SP1 SP1 GPR124 GPR124 LOC102739213 LOC102739213 GATA3 GATA3 VILL VILL MAP3K3 MAP3K3 ETS1 ETS1 IFNG IFNG AKT3 AKT3 JUN JUN GPLD1 GPLD1 HDAC7 HDAC7 HIF1A HIF1A AKT1 AKT1 TGFB2 TGFB2 ATOH8 ATOH8 ITGB1BP1 ITGB1BP1 TEK TEK P2RX4 P2RX4 LOC102738400 LOC102738400 RAB25 RAB25 FGF7 FGF7 MTOR MTOR BMPR2 BMPR2 NUS1 NUS1 ITGB3 ITGB3 HSPB1 HSPB1 RAB11B RAB11B SRC SRC HBEGF HBEGF FGF10 FGF10 ARF6 ARF6 LOC102726446 LOC102726446 LOC102739837 LOC102739837 FGF16 FGF16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF580Zinc finger protein 580. (172 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102736354ATP synthase subunit alpha, mitochondrial-like. (189 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
LOC102741867Villin-1-like. (505 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
LOC102734950Forkhead box protein P1-like. (351 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AAMPAngio-associated migratory cell protein isoform X1. (436 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102730108Neuropilin-1-like. (465 aa)
LOC102738856Villin-like protein-like. (205 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
SASH1SAM and SH3 domain-containing protein 1-like. (1070 aa)
INSL3Insulin-like 3. (130 aa)
KIAA1462Junctional protein associated with coronary artery disease-like. (1360 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (262 aa)
VIL1Villin-1. (330 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (408 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
ANGPT4Angiopoietin-4. (498 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (915 aa)
FGF18Fibroblast growth factor 18. (116 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
LOC102725841Microtubule-associated protein RP/EB family member 2-like. (124 aa)
RRASRas-related protein R-Ras. (218 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
SRPX2Sushi repeat-containing protein SRPX2. (465 aa)
PPM1FProtein phosphatase 1F. (287 aa)
LOC102746002Calpain-7-like; Belongs to the peptidase C2 family. (813 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
GPR124G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1332 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
VILLVillin-like protein-like. (375 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (600 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (928 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ATOH8Protein atonal homolog 8. (318 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
LOC102738400Annexin. (345 aa)
RAB25Ras-related protein Rab-25. (213 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
NUS1nogo-B receptor-like. (293 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
SRCTyrosine-protein kinase. (536 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
LOC102739837Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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