node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMBRA1 | ATG5 | A0A2U3YWA7 | A0A2U3Y6R5 | Activating molecule in BECN1-regulated autophagy protein 1-like. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.499 |
ATG5 | AMBRA1 | A0A2U3Y6R5 | A0A2U3YWA7 | Autophagy protein 5; Involved in autophagic vesicle formation. | Activating molecule in BECN1-regulated autophagy protein 1-like. | 0.499 |
ATG5 | IFNG | A0A2U3Y6R5 | A0A2U3Y8N2 | Autophagy protein 5; Involved in autophagic vesicle formation. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.401 |
ATG5 | LOC102744509 | A0A2U3Y6R5 | A0A2U3Z6M9 | Autophagy protein 5; Involved in autophagic vesicle formation. | Autophagy protein 5-like. | 0.900 |
ATG5 | TP53 | A0A2U3Y6R5 | A0A2U3Y5G3 | Autophagy protein 5; Involved in autophagic vesicle formation. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.497 |
DNMT1 | TP53 | A0A2U3YSF5 | A0A2U3Y5G3 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.764 |
E2F3 | TP53 | A0A2U3YUH8 | A0A2U3Y5G3 | Transcription factor E2F3-like isoform X1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.511 |
IFNG | ATG5 | A0A2U3Y8N2 | A0A2U3Y6R5 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.401 |
IFNG | TP53 | A0A2U3Y8N2 | A0A2U3Y5G3 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.608 |
LOC102727186 | NKX2-5 | A0A2U3Z5T9 | A0A2U3Y2T5 | Heart- and neural crest derivatives-expressed protein 2-like. | Homeobox protein Nkx-2.5. | 0.795 |
LOC102744509 | ATG5 | A0A2U3Z6M9 | A0A2U3Y6R5 | Autophagy protein 5-like. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.900 |
LOC102746954 | TP53 | A0A2U3Z2V1 | A0A2U3Y5G3 | Fructose-2,6-bisphosphatase TIGAR. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.951 |
LRP6 | SFRP2 | A0A2U3XNU0 | A0A2U3X789 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Secreted frizzled-related protein 2. | 0.538 |
NKX2-5 | LOC102727186 | A0A2U3Y2T5 | A0A2U3Z5T9 | Homeobox protein Nkx-2.5. | Heart- and neural crest derivatives-expressed protein 2-like. | 0.795 |
NKX2-5 | TP53 | A0A2U3Y2T5 | A0A2U3Y5G3 | Homeobox protein Nkx-2.5. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.539 |
NUPR1 | TP53 | A0A2U3XRG6 | A0A2U3Y5G3 | Nuclear protein 1 isoform X1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.488 |
SFRP2 | LRP6 | A0A2U3X789 | A0A2U3XNU0 | Secreted frizzled-related protein 2. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.538 |
TP53 | ATG5 | A0A2U3Y5G3 | A0A2U3Y6R5 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.497 |
TP53 | DNMT1 | A0A2U3Y5G3 | A0A2U3YSF5 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.764 |
TP53 | E2F3 | A0A2U3Y5G3 | A0A2U3YUH8 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Transcription factor E2F3-like isoform X1. | 0.511 |