STRINGSTRING
LOC102736146 LOC102736146 SFRP2 SFRP2 ATF4 ATF4 IGF1 IGF1 LYPD3 LYPD3 RBM10 RBM10 LRP6 LRP6 NUPR1 NUPR1 PPP1R10 PPP1R10 CCDC142 CCDC142 NKX2-5 NKX2-5 TP53 TP53 ATG5 ATG5 IFNG IFNG KIFAP3 KIFAP3 LOC102747201 LOC102747201 NOL3 NOL3 ALOX12 ALOX12 DNMT1 DNMT1 E2F3 E2F3 AMBRA1 AMBRA1 LOC102746954 LOC102746954 LOC102727186 LOC102727186 LOC102744509 LOC102744509 APOH APOH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
LYPD3ly6/PLAUR domain-containing protein 3. (343 aa)
RBM10RNA-binding protein 10 isoform X1. (1071 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
PPP1R10Serine/threonine-protein phosphatase 1 regulatory subunit 10-like. (839 aa)
CCDC142Coiled-coil domain-containing protein 142. (766 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
KIFAP3Kinesin-associated protein 3. (748 aa)
LOC102747201Deleted in autism protein 1. (430 aa)
NOL3Nucleolar protein 3. (212 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1613 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
LOC102746954Fructose-2,6-bisphosphatase TIGAR. (270 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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