STRINGSTRING
SFRP1 SFRP1 SFRP2 SFRP2 NOG NOG FOXA1 FOXA1 GREM1 GREM1 SDHAF2 SDHAF2 EZH2 EZH2 SNAI1 SNAI1 PTEN PTEN LOC102732067 LOC102732067 WWTR1 WWTR1 TBX20 TBX20 EMP2 EMP2 SMAD4 SMAD4 EFNA1 EFNA1 PAWR PAWR MTOR MTOR FERMT2 FERMT2 LOC102732879 LOC102732879 LOC102726900 LOC102726900 LOC102745156 LOC102745156 TGFB2 TGFB2 KIAA2018 KIAA2018 ZNF750 ZNF750 BAMBI BAMBI NKX2-1 NKX2-1 FOXA2 FOXA2 LOC102750752 LOC102750752 GATA3 GATA3 SPRY1 SPRY1 PHLDB1 PHLDB1 LOC102745380 LOC102745380 ADIPOR1 ADIPOR1 EPHA4 EPHA4 DAG1 DAG1 LDLRAD4 LDLRAD4 LRG1 LRG1 TGFB1 TGFB1 TGFB3 TGFB3 LOC102731623 LOC102731623 LOC102740025 LOC102740025 ALX1 ALX1 LEF1 LEF1 LOC102743045 LOC102743045 BCL9L BCL9L LOC102740547 LOC102740547 LOC102744093 LOC102744093 LOC102730318 LOC102730318 BMP2 BMP2 ZNF703 ZNF703 VASN VASN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP1Secreted frizzled-related protein 1. (303 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
GREM1Gremlin. (184 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
TBX20T-box transcription factor TBX20. (447 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
FERMT2Fermitin family homolog 2 isoform X1. (687 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KIAA2018Basic helix-loop-helix domain-containing protein KIAA2018 homolog. (2232 aa)
ZNF750Zinc finger protein 750. (715 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (237 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
FOXA2Hepatocyte nuclear factor 3-beta-like. (465 aa)
LOC102750752Lysyl oxidase homolog 2-like. (126 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
PHLDB1Pleckstrin homology-like domain family B member 1. (1381 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
DAG1Dystroglycan isoform X1. (891 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform X1. (269 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (354 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC102731623Serine protease hepsin-like. (82 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
ALX1ALX homeobox protein 1. (326 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X1. (1495 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
ZNF703Zinc finger protein 703-like. (591 aa)
VASNVasorin. (676 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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