STRINGSTRING
AQP1 AQP1 SPINK13 SPINK13 BIRC3 BIRC3 SERPINB10 SERPINB10 BST2 BST2 UBE2Z UBE2Z NOL3 NOL3 RPS6KA3 RPS6KA3 SERPINF2 SERPINF2 THBS1 THBS1 SPINT1 SPINT1 XIAP XIAP PAK2 PAK2 LOC102737106 LOC102737106 CSTL1 CSTL1 LOC102736490 LOC102736490 LOC102736798 LOC102736798 CST8 CST8 LOC102738506 LOC102738506 CST11 CST11 CSTA CSTA KNG1 KNG1 AHSG AHSG FETUB FETUB LOC102735209 LOC102735209 LOC102736707 LOC102736707 SERPINA11 SERPINA11 SERPINA12 SERPINA12 SERPINA9 SERPINA9 SERPINA5 SERPINA5 SERPINA4 SERPINA4 SERPINA3 SERPINA3 ITIH1 ITIH1 LOC102744248 LOC102744248 RFFL RFFL PRNP PRNP SERPINB9 SERPINB9 SERPIND1 SERPIND1 VILL VILL CDKN2D CDKN2D WFIKKN2 WFIKKN2 FAM124B FAM124B SFN SFN NGF NGF CRYAB CRYAB WFIKKN1 WFIKKN1 GAS6 GAS6 LOC102737090 LOC102737090 TNF TNF PCSK1N PCSK1N DDX3X DDX3X BIRC7 BIRC7 INTS1 INTS1 SPOCK1 SPOCK1 CAAP1 CAAP1 LOC102733882 LOC102733882 TIMP3 TIMP3 C5 C5 SERPINI1 SERPINI1 SERPINI2 SERPINI2 PTGER2 PTGER2 WFDC5 WFDC5 WFDC8 WFDC8 LOC102746776 LOC102746776 LOC102737881 LOC102737881 SLPI SLPI LOC102735968 LOC102735968 LOC102743592 LOC102743592 TIMP4 TIMP4 LOC102728215 LOC102728215 SERPINE1 SERPINE1 SRC SRC SERPINC1 SERPINC1 LOC102734862 LOC102734862 USP14 USP14 SPINK8 SPINK8 LAMTOR5 LAMTOR5 SERPINA7 SERPINA7 SPINK5 SPINK5 SPINK1 SPINK1 TIMP1 TIMP1 PLAUR PLAUR VTN VTN LXN LXN APLP2 APLP2 PAPLN PAPLN LOC102732054 LOC102732054 SPINK2 SPINK2 SH3RF1 SH3RF1 LOC102750498 LOC102750498 CSN2 CSN2 CD109 CD109 UCHL5 UCHL5 SERPING1 SERPING1 LOC102740826 LOC102740826 SFRP2 SFRP2 SPOCK3 SPOCK3 HGF HGF SERPINB6 SERPINB6 SERPINH1 SERPINH1 LOC102742613 LOC102742613 DPEP1 DPEP1 LOC102742911 LOC102742911 SERPINB13 SERPINB13 SERPINB12 SERPINB12 SERPINB5 SERPINB5 SERPINB3 SERPINB3 TMED10 TMED10 SERPINE3 SERPINE3 PSMF1 PSMF1 BIRC5 BIRC5 LOC102744722 LOC102744722 AFMID AFMID LOC102735161 LOC102735161 LOC102745644 LOC102745644 SPINK7 SPINK7 PRDX5 PRDX5 LOC102745401 LOC102745401 LOC102748902 LOC102748902 LOC102732719 LOC102732719 PARK7 PARK7 ITIH6 ITIH6 USP47 USP47 ITIH2 ITIH2 SERPINB7 SERPINB7 SERPINB8 SERPINB8 SERPINB2 SERPINB2 LOC102748009 LOC102748009 LOC102737563 LOC102737563 LOC102743801 LOC102743801 LOC102745948 LOC102745948 LOC102741867 LOC102741867 SIAH2 SIAH2 AGT AGT SPINT2 SPINT2 LOC102738856 LOC102738856 BIRC2 BIRC2 ITIH5 ITIH5 PEBP1 PEBP1 TNFSF14 TNFSF14 RNF34 RNF34 CRYAA CRYAA VIL1 VIL1 TNFAIP8 TNFAIP8 PIH1D1 PIH1D1 FAM124A FAM124A IFI6 IFI6 CST7 CST7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP1Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
SPINK13Serine protease inhibitor Kazal-type 13. (79 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
SERPINB10Serpin B10; Belongs to the serpin family. (397 aa)
BST2Bone marrow stromal antigen 2. (188 aa)
UBE2ZUbiquitin-conjugating enzyme E2 Z. (246 aa)
NOL3Nucleolar protein 3. (212 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SERPINF2Alpha-2-antiplasmin; Belongs to the serpin family. (415 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
SPINT1Kunitz-type protease inhibitor 1. (511 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LOC102737106Cystatin-13-like isoform X1. (141 aa)
CSTL1Cystatin-like 1. (137 aa)
LOC102736490cystatin-C-like. (149 aa)
LOC102736798Cystatin-9-like. (155 aa)
CST8Cystatin-8. (142 aa)
LOC102738506Cystatin-9-like. (136 aa)
CST11Cystatin-11. (137 aa)
CSTAcystatin-A; Belongs to the cystatin family. (98 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
AHSGalpha-2-HS-glycoprotein isoform X1. (364 aa)
FETUBfetuin-B. (384 aa)
LOC102735209Delta(24)-sterol reductase-like. (195 aa)
LOC102736707Delta(24)-sterol reductase-like. (136 aa)
SERPINA11Serpin A11; Belongs to the serpin family. (422 aa)
SERPINA12Serpin A12; Belongs to the serpin family. (416 aa)
SERPINA9Serpin A9; Belongs to the serpin family. (418 aa)
SERPINA5Plasma serine protease inhibitor; Belongs to the serpin family. (416 aa)
SERPINA4Kallistatin; Belongs to the serpin family. (430 aa)
SERPINA3Alpha-1-antichymotrypsin; Belongs to the serpin family. (421 aa)
ITIH1Inter-alpha-trypsin inhibitor heavy chain H1. (910 aa)
LOC102744248Notchless protein homolog 1-like. (151 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (298 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
SERPINB9Serpin B9 isoform X1; Belongs to the serpin family. (375 aa)
SERPIND1Heparin cofactor 2; Belongs to the serpin family. (116 aa)
VILLVillin-like protein-like. (375 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D isoform X2. (166 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (573 aa)
FAM124BProtein FAM124B. (459 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
CRYABAlpha-crystallin B chain isoform X1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
WFIKKN1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (548 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
LOC102737090Sortilin-related receptor-like. (446 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PCSK1NproSAAS. (143 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (287 aa)
INTS1Integrator complex subunit 1. (2188 aa)
SPOCK1Testican-1-like. (294 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (362 aa)
LOC102733882Whey acidic protein-like. (158 aa)
TIMP3Metalloproteinase inhibitor 3. (143 aa)
C5Complement C5. (1391 aa)
SERPINI1Neuroserpin; Belongs to the serpin family. (326 aa)
SERPINI2Serpin I2 isoform X3; Belongs to the serpin family. (405 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (353 aa)
WFDC5WAP four-disulfide core domain protein 5. (121 aa)
WFDC8WAP four-disulfide core domain protein 8. (240 aa)
LOC102746776WAP four-disulfide core domain protein 10A-like. (110 aa)
LOC102737881Antileukoproteinase-like. (141 aa)
SLPIAntileukoproteinase. (130 aa)
LOC102735968Protein AMBP-like. (235 aa)
LOC102743592Metalloproteinase inhibitor 2-like. (209 aa)
TIMP4Metalloproteinase inhibitor 4. (224 aa)
LOC102728215Complement C3-like. (768 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
SRCTyrosine-protein kinase. (536 aa)
SERPINC1antithrombin-III; Belongs to the serpin family. (465 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
SPINK8Serine protease inhibitor Kazal-type 8. (103 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (91 aa)
SERPINA7Thyroxine-binding globulin; Belongs to the serpin family. (414 aa)
SPINK5Serine protease inhibitor Kazal-type 5-like. (1068 aa)
SPINK1Pancreatic secretory trypsin inhibitor. (79 aa)
TIMP1Metalloproteinase inhibitor 1. (207 aa)
PLAURUrokinase plasminogen activator surface receptor isoform X1. (335 aa)
VTNVitronectin. (456 aa)
LXNLatexin. (228 aa)
APLP2Amyloid-like protein 2 isoform X1. (763 aa)
PAPLNPapilin. (1268 aa)
LOC102732054cystatin-B-like; Belongs to the cystatin family. (98 aa)
SPINK2Serine protease inhibitor Kazal-type 2. (87 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (872 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
CSN2Beta-casein. (261 aa)
CD109CD109 antigen. (1322 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (476 aa)
LOC102740826Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (268 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SPOCK3Testican-3-like isoform X1. (436 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (179 aa)
SERPINH1Serpin H1 isoform X3; Belongs to the serpin family. (418 aa)
LOC102742613Alpha-2-macroglobulin-like. (1480 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa)
LOC102742911Alpha-2-macroglobulin-like. (270 aa)
SERPINB13Serpin B13; Belongs to the serpin family. (391 aa)
SERPINB12Serpin B12 isoform X1; Belongs to the serpin family. (425 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (242 aa)
SERPINB3Serpin B3; Belongs to the serpin family. (389 aa)
TMED10Transmembrane emp24 domain-containing protein 10; Belongs to the EMP24/GP25L family. (94 aa)
SERPINE3Serpin E3; Belongs to the serpin family. (405 aa)
PSMF1Proteasome inhibitor PI31 subunit. (128 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (74 aa)
LOC102744722LOW QUALITY PROTEIN: pregnancy zone protein-like. (1064 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (265 aa)
LOC102735161Corticosteroid-binding globulin-like; Belongs to the serpin family. (147 aa)
LOC102745644Heparin cofactor 2-like isoform X1; Belongs to the serpin family. (296 aa)
SPINK7LOW QUALITY PROTEIN: serine peptidase inhibitor, Kazal type 7 (Putative). (76 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (219 aa)
LOC102745401Venom factor-like. (218 aa)
LOC102748902Complement C3-like. (383 aa)
LOC102732719Ribosomal protein S6 kinase alpha-1-like. (200 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
ITIH6LOW QUALITY PROTEIN: inter-alpha-trypsin inhibitor heavy chain family, member 6. (868 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47; Belongs to the peptidase C19 family. (1287 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2. (898 aa)
SERPINB7Serpin B7 isoform X1; Belongs to the serpin family. (380 aa)
SERPINB8Serpin B8; Belongs to the serpin family. (374 aa)
SERPINB2Plasminogen activator inhibitor 2; Belongs to the serpin family. (416 aa)
LOC102748009Serpin B11-like; Belongs to the serpin family. (233 aa)
LOC102737563Complement C5-like. (186 aa)
LOC102743801Delta(24)-sterol reductase-like. (269 aa)
LOC102745948CD27 antigen-like. (261 aa)
LOC102741867Villin-1-like. (505 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
SPINT2Kunitz-type protease inhibitor 2. (252 aa)
LOC102738856Villin-like protein-like. (205 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain H5. (535 aa)
PEBP1Phosphatidylethanolamine-binding protein 1 isoform X2. (187 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14. (241 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
CRYAAAlpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
VIL1Villin-1. (330 aa)
TNFAIP8Tumor necrosis factor alpha-induced protein 8. (166 aa)
PIH1D1PIH1 domain-containing protein 1 isoform X1. (347 aa)
FAM124AProtein FAM124A. (411 aa)
IFI6Interferon alpha-inducible protein 6 isoform X1. (176 aa)
CST7cystatin-F. (153 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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