STRINGSTRING
CLDN4 CLDN4 LOC102729504 LOC102729504 LOC102730318 LOC102730318 CASP8 CASP8 GPER1 GPER1 RCN3 RCN3 CASP9 CASP9 LOC102748129 LOC102748129 LAPTM5 LAPTM5 PYCARD PYCARD NKX3-1 NKX3-1 LOC102738538 LOC102738538 CAV1 CAV1 APH1A APH1A SFRP2 SFRP2 CASP8AP2 CASP8AP2 S100A9 S100A9 FGL2 FGL2 CLEC7A CLEC7A DDRGK1 DDRGK1 PRR7 PRR7 PRELID1 PRELID1 LOC102725978 LOC102725978 WDR48 WDR48 LOC102738241 LOC102738241 CASP2 CASP2 IFT57 IFT57 GNB2L1 GNB2L1 ATP2A3 ATP2A3 CTSH CTSH NODAL NODAL LOC102725545 LOC102725545 CARD9 CARD9 NDUFA13 NDUFA13 LOC102734059 LOC102734059 PAWR PAWR LOC102745146 LOC102745146 ACVR1C ACVR1C EFNA1 EFNA1 CYR61 CYR61 FOXL2 FOXL2 PCOLCE PCOLCE FIS1 FIS1 SOX7 SOX7 TNFSF10 TNFSF10 LOC102737759 LOC102737759 PMAIP1 PMAIP1 NLRC4 NLRC4 PCOLCE2 PCOLCE2 ADRM1 ADRM1 YJEFN3 YJEFN3 LOC102738778 LOC102738778 HTRA2 HTRA2 F2R F2R CRADD CRADD TNFSF15 TNFSF15 PSMD14 PSMD14 TANK TANK MTCH1 MTCH1 LOC102750923 LOC102750923 AGER AGER GSN GSN APH1B APH1B FADD FADD NOD1 NOD1 NLRP12 NLRP12 FASLG FASLG BAK1 BAK1 MUL1 MUL1 DDX3X DDX3X TNF TNF LOC102745161 LOC102745161 PSME1 PSME1 CIDEB CIDEB PSME2 PSME2 PSME3 PSME3 PDCD5 PDCD5 TBC1D10A TBC1D10A BCL10 BCL10 PML PML LOC102731392 LOC102731392 LOC102747784 LOC102747784 LOC102739213 LOC102739213 PIDD PIDD ACER2 ACER2 NLRP6 NLRP6 PDCD6 PDCD6 PSENEN PSENEN ANP32B ANP32B TFAP4 TFAP4 EPHA4 EPHA4 PPM1F PPM1F LOC102749183 LOC102749183 LOC102746004 LOC102746004 LOC102734861 LOC102734861 LOC102746860 LOC102746860 LOC102739786 LOC102739786 LOC102747270 LOC102747270 LOC102741358 LOC102741358 LOC102748833 LOC102748833 FAM162A FAM162A LOC102751101 LOC102751101 LOC102737664 LOC102737664 NCSTN NCSTN BOK BOK STAT3 STAT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RCN3Reticulocalbin-3. (328 aa)
CASP9Caspase-9. (171 aa)
LOC102748129Egl nine homolog 3-like. (239 aa)
LAPTM5Lysosomal-associated transmembrane protein 5. (263 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
LOC102738538Sentrin-specific protease 1-like. (93 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
APH1AGamma-secretase subunit APH-1A isoform X1. (265 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
CASP8AP2CASP8-associated protein 2. (1969 aa)
S100A9Protein S100; Belongs to the S-100 family. (140 aa)
FGL2Fibroleukin. (440 aa)
CLEC7AC-type lectin domain family 7 member A. (248 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
PRR7Proline-rich protein 7 isoform X2. (269 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial isoform X1. (219 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
WDR48WD repeat-containing protein 48 isoform X1. (677 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (312 aa)
IFT57Intraflagellar transport protein 57 homolog. (429 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
NODALNodal homolog. (348 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
CARD9Caspase recruitment domain-containing protein 9-like. (536 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
LOC102734059Apoptosis-inducing factor 1, mitochondrial-like. (145 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
CYR61Protein CYR61. (382 aa)
FOXL2Forkhead box protein L2. (257 aa)
PCOLCEProcollagen C-endopeptidase enhancer 1. (455 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SOX7Transcription factor SOX-7. (386 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (245 aa)
LOC102737759Cytoplasmic FMR1-interacting protein 2-like. (113 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (908 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (405 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1 isoform X1. (406 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
LOC102738778Apoptosis-inducing factor 1, mitochondrial-like. (210 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform X1. (458 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CRADDDeath domain-containing protein CRADD. (199 aa)
TNFSF15Tumor necrosis factor ligand superfamily member 15. (255 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
MTCH1Mitochondrial carrier homolog 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
GSNGelsolin. (189 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
PSME1Proteasome activator complex subunit 1 isoform X1. (249 aa)
CIDEBCell death activator CIDE-B. (221 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (239 aa)
PSME3Proteasome activator complex subunit 3 isoform X3. (254 aa)
PDCD5Programmed cell death protein 5. (125 aa)
TBC1D10ATBC1 domain family member 10A. (376 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
PMLProtein PML. (880 aa)
LOC102731392Uveal autoantigen with coiled-coil domains and ankyrin repeats-like isoform X1. (1417 aa)
LOC102747784Putative ubiquitin carboxyl-terminal hydrolase 50-like; Belongs to the peptidase C19 family. (373 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
PIDDP53-induced protein with a death domain. (916 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (125 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (893 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
PSENENGamma-secretase subunit PEN-2 isoform X1. (101 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (259 aa)
TFAP4Transcription factor AP-4. (337 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
PPM1FProtein phosphatase 1F. (287 aa)
LOC102749183Fibulin-1-like. (624 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102746860Apoptosis-inducing factor 1, mitochondrial-like. (232 aa)
LOC102739786Huntingtin-interacting protein 1-like. (415 aa)
LOC102747270GRAM domain-containing protein 4-like. (374 aa)
LOC102741358Protein S100; Belongs to the S-100 family. (89 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
FAM162AProtein FAM162A. (155 aa)
LOC102751101Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (178 aa)
LOC102737664Gelsolin-like. (513 aa)
NCSTNNicastrin. (602 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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