(40 nodes) Regulation of gliogenesis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR37L1	Prosaposin receptor GPR37L1. (477 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	DLX2	Homeobox protein DLX-2. (330 aa)
	RB1	Retinoblastoma-associated protein. (846 aa)
	ZNF365	Protein ZNF365. (407 aa)
	LOC102745380	Histone-lysine N-methyltransferase EZH2-like. (556 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1. (215 aa)
	NKX6-2	Homeobox protein Nkx-6.2. (168 aa)
	LDLR	Low-density lipoprotein receptor. (861 aa)
	LOC102738222	RING finger protein 112-like. (617 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	UFL1	E3 UFM1-protein ligase 1. (792 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	TENM4	Teneurin-4. (1083 aa)
	IL34	Interleukin-34. (236 aa)
	SOX10	Transcription factor SOX-10. (469 aa)
	LOC102732425	Myelin-associated glycoprotein-like. (382 aa)
	NTN1	Netrin-1-like. (402 aa)
	NF1	Neurofibromin-like. (1269 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	LOC102738369	Merlin-like. (110 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	GFAP	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (432 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (543 aa)
	NKX6-1	Homeobox protein Nkx-6.1-like. (366 aa)
	EGR2	E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	SOX8	Transcription factor SOX-8. (412 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	LOC102741936	Trem-like transcript 1 protein-like. (128 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (499 aa)
	PLAG1	Zinc finger protein PLAG1 isoform X1. (499 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LOC102747252	Protein kinase C eta type-like. (89 aa)
	EZH2	Histone-lysine N-methyltransferase EZH2. (144 aa)
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	ATOH1	Protein atonal homolog 1. (355 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	NOG	A0A2U3Z3S1	A0A2U3XEL8	Bone morphogenetic protein 2-like.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.971
BMP2	TGFB1	A0A2U3Z3S1	A0A2U3YVA3	Bone morphogenetic protein 2-like.	Transforming growth factor beta-1.	0.479
BMP2	TNF	A0A2U3Z3S1	A0A2U3Y499	Bone morphogenetic protein 2-like.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.451
DLX1	DLX2	A0A2U3XK47	A0A2U3Y9S8	Homeobox protein DLX-1 isoform X1.	Homeobox protein DLX-2.	0.831
DLX2	DLX1	A0A2U3Y9S8	A0A2U3XK47	Homeobox protein DLX-2.	Homeobox protein DLX-1 isoform X1.	0.831
DLX2	GFAP	A0A2U3Y9S8	A0A2U3XWT2	Homeobox protein DLX-2.	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	0.474
DLX2	SOX10	A0A2U3Y9S8	A0A2U3YWQ9	Homeobox protein DLX-2.	Transcription factor SOX-10.	0.753
EGR2	LOC102732425	A0A2U3XUA7	A0A2U3YWU4	E3 SUMO-protein ligase EGR2 isoform X1.	Myelin-associated glycoprotein-like.	0.460
EGR2	SOX10	A0A2U3XUA7	A0A2U3YWQ9	E3 SUMO-protein ligase EGR2 isoform X1.	Transcription factor SOX-10.	0.738
EGR2	SOX8	A0A2U3XUA7	A0A2U3Y6D3	E3 SUMO-protein ligase EGR2 isoform X1.	Transcription factor SOX-8.	0.515
EZH2	LOC102745380	A0A2U3XHJ2	A0A2U3YH25	Histone-lysine N-methyltransferase EZH2.	Histone-lysine N-methyltransferase EZH2-like.	0.900
EZH2	TP53	A0A2U3XHJ2	A0A2U3Y5G3	Histone-lysine N-methyltransferase EZH2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.589
GFAP	DLX2	A0A2U3XWT2	A0A2U3Y9S8	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Homeobox protein DLX-2.	0.474
GFAP	LOC102741936	A0A2U3XWT2	A0A2U3XCU2	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Trem-like transcript 1 protein-like.	0.607
GFAP	MECP2	A0A2U3XWT2	A0A2U3Y6Q6	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.402
GFAP	NF1	A0A2U3XWT2	A0A2U3Z255	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Neurofibromin-like.	0.531
GFAP	NOG	A0A2U3XWT2	A0A2U3XEL8	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.562
GFAP	SOX10	A0A2U3XWT2	A0A2U3YWQ9	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Transcription factor SOX-10.	0.779
GFAP	TNF	A0A2U3XWT2	A0A2U3Y499	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.569
GFAP	TP53	A0A2U3XWT2	A0A2U3Y5G3	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.487