(36 nodes) Myotube differentiation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102729189	Dedicator of cytokinesis protein 5-like. (273 aa)
	CAPN8	LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC102735070	Dedicator of cytokinesis protein 5-like; Belongs to the DOCK family. (294 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	LOC102729702	Prostaglandin F2 receptor negative regulator-like. (493 aa)
	PLEKHO1	Pleckstrin homology domain-containing family O member 1. (226 aa)
	LOC102750394	Dedicator of cytokinesis protein 1-like. (237 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (471 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	TMEM8C	Protein myomaker. (221 aa)
	DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2. (629 aa)
	NPHS1	Nephrin. (1242 aa)
	BIN3	Bridging integrator 3. (253 aa)
	DNER	Delta and Notch-like epidermal growth factor-related receptor. (448 aa)
	STAC3	SH3 and cysteine-rich domain-containing protein 3 isoform X1. (364 aa)
	LOC102733393	Protein FAM65B-like. (563 aa)
	SMYD3	Histone-lysine N-methyltransferase SMYD3. (190 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	CD9	Tetraspanin. (226 aa)
	LOC102748855	Delta and Notch-like epidermal growth factor-related receptor-like. (297 aa)
	ACTN1	Alpha-actinin-1. (406 aa)
	KLHL41	Kelch-like protein 41. (606 aa)
	KIAA1161	Uncharacterized family 31 glucosidase KIAA1161 homolog; Belongs to the glycosyl hydrolase 31 family. (714 aa)
	LOC102747663	Spermatid-specific manchette-related protein 1-like isoform X1. (164 aa)
	LOC102733072	Myoferlin-like. (457 aa)
	TMEM182	Transmembrane protein 182. (229 aa)
	HOMER1	Homer protein homolog 1 isoform X1. (354 aa)
	LOC102738462	Cell adhesion molecule-related/down-regulated by oncogenes-like. (620 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	ADAMTS15	A disintegrin and metalloproteinase with thrombospondin motifs 15. (950 aa)
	SIX4	Homeobox protein SIX4. (778 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	ITGB1	A0A2U3XWN7	A0A2U3Y1P5	Alpha-actinin-1.	Integrin beta; Belongs to the integrin beta chain family.	0.903
CAV2	CAV3	A0A2U3XC92	A0A2U3XYT3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV2	ITGB1	A0A2U3XC92	A0A2U3Y1P5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.820
CAV3	CAV2	A0A2U3XYT3	A0A2U3XC92	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV3	ITGB1	A0A2U3XYT3	A0A2U3Y1P5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.815
CAV3	LOC102733072	A0A2U3XYT3	A0A2U3XR47	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myoferlin-like.	0.559
CAV3	MYOD1	A0A2U3XYT3	A0A2U3Z4X5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.452
CD9	ITGB1	A0A2U3XX36	A0A2U3Y1P5	Tetraspanin.	Integrin beta; Belongs to the integrin beta chain family.	0.828
CD9	LOC102729702	A0A2U3XX36	A0A2U3YZK9	Tetraspanin.	Prostaglandin F2 receptor negative regulator-like.	0.840
ITGB1	ACTN1	A0A2U3Y1P5	A0A2U3XWN7	Integrin beta; Belongs to the integrin beta chain family.	Alpha-actinin-1.	0.903
ITGB1	CAV2	A0A2U3Y1P5	A0A2U3XC92	Integrin beta; Belongs to the integrin beta chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.820
ITGB1	CAV3	A0A2U3Y1P5	A0A2U3XYT3	Integrin beta; Belongs to the integrin beta chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.815
ITGB1	CD9	A0A2U3Y1P5	A0A2U3XX36	Integrin beta; Belongs to the integrin beta chain family.	Tetraspanin.	0.828
KIAA1161	LOC102747663	A0A2U3XTC4	A0A2U3XT74	Uncharacterized family 31 glucosidase KIAA1161 homolog; Belongs to the glycosyl hydrolase 31 family.	Spermatid-specific manchette-related protein 1-like isoform X1.	0.544
KLHL41	STAC3	A0A2U3XTP2	A0A2U3Y941	Kelch-like protein 41.	SH3 and cysteine-rich domain-containing protein 3 isoform X1.	0.405
KLHL41	TMEM182	A0A2U3XTP2	A0A2U3XPR6	Kelch-like protein 41.	Transmembrane protein 182.	0.420
KLHL41	TMEM8C	A0A2U3XTP2	A0A2U3YK13	Kelch-like protein 41.	Protein myomaker.	0.519
LOC102725943	MEF2C	A0A2U3YQY8	A0A2U3YMC3	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.819
LOC102729189	LOC102735070	A0A2U3YWJ7	A0A2U3Z7B4	Dedicator of cytokinesis protein 5-like.	Dedicator of cytokinesis protein 5-like; Belongs to the DOCK family.	0.900
LOC102729702	CD9	A0A2U3YZK9	A0A2U3XX36	Prostaglandin F2 receptor negative regulator-like.	Tetraspanin.	0.840