(28 nodes) Cholesterol binding network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	NPC1L1	niemann-Pick C1-like protein 1. (1331 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
	LOC102729506	GRAM domain-containing protein 1B-like. (248 aa)
	TSPO2	Translocator protein 2 isoform X1. (171 aa)
	STARD3	stAR-related lipid transfer protein 3 isoform X1. (445 aa)
	LOC102737056	Oxysterol-binding protein; Belongs to the OSBP family. (662 aa)
	VDAC2	Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
	ANXA6	Annexin. (673 aa)
	NPC2	Epididymal secretory protein E1. (133 aa)
	LOC102735509	Oxysterol-binding protein-related protein 7-like. (241 aa)
	OSBPL2	Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
	LOC102742218	Lysosome membrane protein 2-like; Belongs to the CD36 family. (123 aa)
	SOAT2	O-acyltransferase. (524 aa)
	STARD5	stAR-related lipid transfer protein 5. (213 aa)
	APOF	Apolipoprotein F. (265 aa)
	NFE2L1	Nuclear factor erythroid 2-related factor 1 isoform X3. (622 aa)
	STARD3NL	MLN64 N-terminal domain homolog. (220 aa)
	SYP	Synaptophysin. (313 aa)
	PTCH1	Protein patched homolog 1. (1301 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (891 aa)
	NPC1	niemann-Pick C1 protein. (1276 aa)
	SOAT1	O-acyltransferase. (484 aa)
	OSBPL6	Oxysterol-binding protein; Belongs to the OSBP family. (959 aa)
	SCP2	Non-specific lipid-transfer protein isoform X4. (143 aa)
	FABP9	Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	PMP2	Myelin P2 protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	FABP12	LOW QUALITY PROTEIN: fatty acid-binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (140 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOF	SOAT1	A0A2U3YBK4	A0A2U3XRV7	Apolipoprotein F.	O-acyltransferase.	0.473
APOF	SOAT2	A0A2U3YBK4	A0A2U3YD41	Apolipoprotein F.	O-acyltransferase.	0.473
LOC102729506	NPC1	A0A2U3Z3R5	A0A2U3XTB2	GRAM domain-containing protein 1B-like.	niemann-Pick C1 protein.	0.539
LOC102729506	STARD3	A0A2U3Z3R5	A0A2U3Z3E4	GRAM domain-containing protein 1B-like.	stAR-related lipid transfer protein 3 isoform X1.	0.477
LOC102735509	NFE2L1	A0A2U3YMW9	A0A2U3Y674	Oxysterol-binding protein-related protein 7-like.	Nuclear factor erythroid 2-related factor 1 isoform X3.	0.681
NFE2L1	LOC102735509	A0A2U3Y674	A0A2U3YMW9	Nuclear factor erythroid 2-related factor 1 isoform X3.	Oxysterol-binding protein-related protein 7-like.	0.681
NPC1	LOC102729506	A0A2U3XTB2	A0A2U3Z3R5	niemann-Pick C1 protein.	GRAM domain-containing protein 1B-like.	0.539
NPC1	NPC2	A0A2U3XTB2	A0A2U3YPR1	niemann-Pick C1 protein.	Epididymal secretory protein E1.	0.998
NPC1	OSBPL5	A0A2U3XTB2	A0A2U3XY58	niemann-Pick C1 protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.903
NPC1	OSBPL8	A0A2U3XTB2	A0A2U3Y267	niemann-Pick C1 protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.537
NPC1	STARD3	A0A2U3XTB2	A0A2U3Z3E4	niemann-Pick C1 protein.	stAR-related lipid transfer protein 3 isoform X1.	0.543
NPC1L1	NPC2	A0A2U3XYL5	A0A2U3YPR1	niemann-Pick C1-like protein 1.	Epididymal secretory protein E1.	0.917
NPC1L1	OSBPL5	A0A2U3XYL5	A0A2U3XY58	niemann-Pick C1-like protein 1.	Oxysterol-binding protein; Belongs to the OSBP family.	0.645
NPC1L1	OSBPL8	A0A2U3XYL5	A0A2U3Y267	niemann-Pick C1-like protein 1.	Oxysterol-binding protein; Belongs to the OSBP family.	0.507
NPC2	NPC1	A0A2U3YPR1	A0A2U3XTB2	Epididymal secretory protein E1.	niemann-Pick C1 protein.	0.998
NPC2	NPC1L1	A0A2U3YPR1	A0A2U3XYL5	Epididymal secretory protein E1.	niemann-Pick C1-like protein 1.	0.917
NPC2	STARD3	A0A2U3YPR1	A0A2U3Z3E4	Epididymal secretory protein E1.	stAR-related lipid transfer protein 3 isoform X1.	0.451
OSBPL5	NPC1	A0A2U3XY58	A0A2U3XTB2	Oxysterol-binding protein; Belongs to the OSBP family.	niemann-Pick C1 protein.	0.903
OSBPL5	NPC1L1	A0A2U3XY58	A0A2U3XYL5	Oxysterol-binding protein; Belongs to the OSBP family.	niemann-Pick C1-like protein 1.	0.645
OSBPL5	STARD3NL	A0A2U3XY58	A0A2U3Y4L9	Oxysterol-binding protein; Belongs to the OSBP family.	MLN64 N-terminal domain homolog.	0.487