STRINGSTRING
LOC102743181 LOC102743181 CHMP4C CHMP4C PCBP1 PCBP1 CSDE1 CSDE1 PCBP2 PCBP2 VTA1 VTA1 CAV1 CAV1 DHX9 DHX9 KPNA2 KPNA2 EIF3B EIF3B VPS4A VPS4A NEDD4 NEDD4 CLEC4G CLEC4G ITGB3 ITGB3 CHMP5 CHMP5 SSB SSB LOC102748356 LOC102748356 EIF3A EIF3A TYRO3 TYRO3 CCNT2 CCNT2 SIVA1 SIVA1 GTF2B GTF2B CHMP4A CHMP4A GAS6 GAS6 TP53 TP53 ATG5 ATG5 CHMP7 CHMP7 CLDN1 CLDN1 LOC102744445 LOC102744445 ANPEP ANPEP AVPR1B AVPR1B FLVCR1 FLVCR1 IST1 IST1 EIF3F EIF3F ADRBK1 ADRBK1 PVRL4 PVRL4 DAG1 DAG1 USF1 USF1 CHMP1A CHMP1A VPS4B VPS4B EIF3D EIF3D MCTS1 MCTS1 TNFRSF14 TNFRSF14 LOC102746022 LOC102746022 EIF3G EIF3G TSG101 TSG101 MVB12B MVB12B MVB12A MVB12A MON1B MON1B SMPD1 SMPD1 AXL AXL LRRC15 LRRC15 LOC102734133 LOC102734133 CHMP2A CHMP2A RAB1A RAB1A PVRL2 PVRL2 CHMP1B CHMP1B PC PC LOC102730108 LOC102730108 ZNF639 ZNF639 VPS18 VPS18 LOC102726269 LOC102726269 LOC102744509 LOC102744509 LOC102730737 LOC102730737 LOC102730434 LOC102730434
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102743181CD209 antigen-like protein 2-like isoform X1. (246 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
PCBP1poly(RC)-binding protein 1 isoform X1. (356 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PCBP2poly(RC)-binding protein 2 isoform X1. (362 aa)
VTA1Vacuolar protein sorting-associated protein VTA1 homolog isoform X1. (279 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
DHX9ATP-dependent RNA helicase A. (1276 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
EIF3BEukaryotic translation initiation factor 3 subunit B. (275 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X1. (1323 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
CHMP5Charged multivesicular body protein 5. (232 aa)
SSBLupus La protein homolog. (406 aa)
LOC102748356Malignant T-cell-amplified sequence. (181 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (1308 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
CCNT2cyclin-T2 isoform X1; Belongs to the cyclin family. (730 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
GTF2BTranscription initiation factor IIB. (316 aa)
CHMP4ALOW QUALITY PROTEIN: charged multivesicular body protein 4a. (265 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
CHMP7Charged multivesicular body protein 7 isoform X1. (450 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC102744445Integrin beta; Belongs to the integrin beta chain family. (197 aa)
ANPEPAminopeptidase. (962 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1. (556 aa)
IST1IST1 homolog isoform X1. (364 aa)
EIF3FEukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (369 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
PVRL4Poliovirus receptor-related protein 4 isoform X1. (509 aa)
DAG1Dystroglycan isoform X1. (891 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
CHMP1ACharged multivesicular body protein 1a. (196 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (451 aa)
MCTS1Malignant T-cell-amplified sequence. (182 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14. (272 aa)
LOC102746022UPF0515 protein C19orf66 homolog isoform X1. (289 aa)
EIF3GEukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (320 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (391 aa)
MVB12BMultivesicular body subunit 12B-like. (292 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
MON1BVacuolar fusion protein MON1 homolog B isoform X1. (551 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
AXLTyrosine-protein kinase receptor UFO. (887 aa)
LRRC15Leucine-rich repeat-containing protein 15. (580 aa)
LOC102734133Pyruvate carboxylase, mitochondrial-like. (725 aa)
CHMP2ACharged multivesicular body protein 2a isoform X1. (222 aa)
RAB1ARas-related protein Rab-1A isoform X1. (205 aa)
PVRL2Poliovirus receptor-related protein 2. (539 aa)
CHMP1BCharged multivesicular body protein 1b. (199 aa)
PCPyruvate carboxylase, mitochondrial. (558 aa)
LOC102730108Neuropilin-1-like. (465 aa)
ZNF639Zinc finger protein 639. (485 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog. (895 aa)
LOC102726269Angiotensin-converting enzyme 2-like. (488 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
LOC102730737Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
LOC102730434Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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