(17 nodes) Histone phosphorylation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	LOC102725945	Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
	LOC102727565	Galactokinase-like. (208 aa)
	CDK2	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
	VRK2	Serine/threonine-protein kinase VRK2-like. (378 aa)
	LOC102731039	Histone H3.3-like. (128 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	SMARCA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa)
	PKN1	Serine/threonine-protein kinase N1. (796 aa)
	AURKB	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (344 aa)
	HIPK4	Homeodomain-interacting protein kinase 4. (615 aa)
	BAZ1B	Tyrosine-protein kinase BAZ1B. (1443 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
	GSG2	Serine/threonine-protein kinase haspin. (770 aa)
	LOC102732330	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102730819	Histone H3; Belongs to the histone H3 family. (136 aa)
	CDK5	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CDK2	A0A2U3YJR1	A0A2U3XBF9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.	0.805
ATM	HIPK4	A0A2U3YJR1	A0A2U3YIC3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Homeodomain-interacting protein kinase 4.	0.451
ATM	LOC102725945	A0A2U3YJR1	A0A2U3X7E5	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily.	0.754
ATM	LOC102730819	A0A2U3YJR1	A0A2U3Z299	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.550
ATM	LOC102731039	A0A2U3YJR1	A0A2U3XLF3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3.3-like.	0.550
ATM	LOC102732330	A0A2U3YJR1	A0A2U3YTU8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.550
AURKB	CDK2	A0A2U3Y3I5	A0A2U3XBF9	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.	0.767
AURKB	GSG2	A0A2U3Y3I5	A0A2U3YRU7	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase haspin.	0.524
AURKB	LOC102725945	A0A2U3Y3I5	A0A2U3X7E5	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily.	0.999
AURKB	LOC102730819	A0A2U3Y3I5	A0A2U3Z299	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Histone H3; Belongs to the histone H3 family.	0.561
AURKB	LOC102731039	A0A2U3Y3I5	A0A2U3XLF3	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Histone H3.3-like.	0.561
AURKB	LOC102732330	A0A2U3Y3I5	A0A2U3YTU8	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Histone H3; Belongs to the histone H3 family.	0.561
AURKB	VRK2	A0A2U3Y3I5	A0A2U3XCF0	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase VRK2-like.	0.446
BAZ1B	LOC102730819	A0A2U3YJQ2	A0A2U3Z299	Tyrosine-protein kinase BAZ1B.	Histone H3; Belongs to the histone H3 family.	0.442
BAZ1B	LOC102731039	A0A2U3YJQ2	A0A2U3XLF3	Tyrosine-protein kinase BAZ1B.	Histone H3.3-like.	0.442
BAZ1B	LOC102732330	A0A2U3YJQ2	A0A2U3YTU8	Tyrosine-protein kinase BAZ1B.	Histone H3; Belongs to the histone H3 family.	0.442
BAZ1B	SMARCA5	A0A2U3YJQ2	A0A2U3XU58	Tyrosine-protein kinase BAZ1B.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5.	0.996
CDK2	ATM	A0A2U3XBF9	A0A2U3YJR1	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.805
CDK2	AURKB	A0A2U3XBF9	A0A2U3Y3I5	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	0.767
CDK2	CDK5	A0A2U3XBF9	A0A2U3Z7K7	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily.	0.549