STRINGSTRING
ORMDL2 ORMDL2 ORMDL1 ORMDL1 GPR116 GPR116 SNAI2 SNAI2 ABCD2 ABCD2 BMP5 BMP5 CERS2 CERS2 CAV1 CAV1 TREM2 TREM2 LOC102741936 LOC102741936 DHH DHH ARMC5 ARMC5 NR1H3 NR1H3 METTL20 METTL20 CNEP1R1 CNEP1R1 BSCL2 BSCL2 LRRN4CL LRRN4CL DNAJC15 DNAJC15 SCP2 SCP2 PDK4 PDK4 RARRES2 RARRES2 SNAI1 SNAI1 TTC39A TTC39A FGFR4 FGFR4 AADAC AADAC PRKAA1 PRKAA1 CREB1 CREB1 IDH1 IDH1 PIK3IP1 PIK3IP1 PLA2G3 PLA2G3 SEC14L3 SEC14L3 LOC102728215 LOC102728215 CD19 CD19 HTR2B HTR2B ZBTB20 ZBTB20 NR0B1 NR0B1 LOC102732272 LOC102732272 FITM2 FITM2 HNF4A HNF4A CYR61 CYR61 H6PD H6PD MTOR MTOR PTCHD2 PTCHD2 ADRA2A ADRA2A LOC102733378 LOC102733378 NCOR1 NCOR1 LOC102732879 LOC102732879 FMO4 FMO4 LOC102739094 LOC102739094 ATG14 ATG14 VAV3 VAV3 FGFR3 FGFR3 LTK LTK LOC102738400 LOC102738400 TEK TEK SLC45A3 SLC45A3 PPARD PPARD EGR1 EGR1 ZFP69 ZFP69 ZMPSTE24 ZMPSTE24 MFSD2A MFSD2A ZFP69B ZFP69B PRMT3 PRMT3 PHB2 PHB2 LPCAT3 LPCAT3 AKT1 AKT1 TNF TNF LOC102735096 LOC102735096 STAT5B STAT5B LHCGR LHCGR HCAR1 HCAR1 LOC102744936 LOC102744936 LOC102738981 LOC102738981 LOC102750030 LOC102750030 LOC102733070 LOC102733070 LOC102750518 LOC102750518 LOC102731864 LOC102731864 LOC102737780 LOC102737780 LOC102740078 LOC102740078 LOC102746559 LOC102746559 PCK1 PCK1 LOC102725895 LOC102725895 LOC102748833 LOC102748833 STAR STAR LOC102744822 LOC102744822 STAT5A STAT5A TREX1 TREX1 BMP2 BMP2 LOC102739775 LOC102739775 ACER1 ACER1 INS INS FGF2 FGF2 LOC102726984 LOC102726984 LOC102746352 LOC102746352 PPARA PPARA ORMDL3 ORMDL3 TYSND1 TYSND1 DKKL1 DKKL1 LOC102734938 LOC102734938 GPER1 GPER1 NR1H2 NR1H2 LOC102743045 LOC102743045 SEC14L5 SEC14L5 PSAP PSAP PDK2 PDK2 LOC102748816 LOC102748816 AMBRA1 AMBRA1 ABHD6 ABHD6 LOC102742922 LOC102742922 TGFB1 TGFB1 PDGFRA PDGFRA ARV1 ARV1 DKK3 DKK3 LPCAT1 LPCAT1 LOC102735329 LOC102735329 DGKQ DGKQ PDGFB PDGFB DAGLB DAGLB VAV2 VAV2 NR1D1 NR1D1 LGALS12 LGALS12 BMP6 BMP6 ELOVL5 ELOVL5 SPHK2 SPHK2 SIRT4 SIRT4 LOC102737823 LOC102737823 LOC102727345 LOC102727345 NR1D2 NR1D2 LOC102729166 LOC102729166 PIK3R4 PIK3R4 TM6SF2 TM6SF2 LOC102747801 LOC102747801 LOC102735415 LOC102735415 LDLR LDLR LOC102747799 LOC102747799 SERPINA12 SERPINA12 PIP4K2B PIP4K2B PDE3B PDE3B HTR2A HTR2A ADIPOR1 ADIPOR1 LONP2 LONP2 MID1IP1 MID1IP1 PRKAG2 PRKAG2 PANK2 PANK2 MBOAT7 MBOAT7 SEC14L4 SEC14L4 ACSL3 ACSL3 NOD2 NOD2 SEC14L2 SEC14L2 PNPLA2 PNPLA2 CD74 CD74 DDX20 DDX20 PIBF1 PIBF1 ABHD5 ABHD5 ABCD1 ABCD1 PIP4K2C PIP4K2C LOC102746290 LOC102746290 IFNG IFNG AKT3 AKT3 LOC102731486 LOC102731486 THRSP THRSP GPLD1 GPLD1 CCL19 CCL19 CCL21 CCL21 STOML2 STOML2 ACADVL ACADVL CTDNEP1 CTDNEP1 GPS2 GPS2 LOC102737090 LOC102737090 LOC102735400 LOC102735400
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (182 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
GPR116Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ABCD2ATP-binding cassette sub-family D member 2 isoform X2. (742 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
CERS2Ceramide synthase 2. (380 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
METTL20Methyltransferase-like protein 20. (266 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1. (125 aa)
BSCL2Seipin isoform X2. (394 aa)
LRRN4CLLRRN4 C-terminal-like protein. (237 aa)
DNAJC15dnaJ homolog subfamily C member 15. (149 aa)
SCP2Non-specific lipid-transfer protein isoform X4. (143 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
RARRES2Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
TTC39ATetratricopeptide repeat protein 39A isoform X3. (550 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
AADACArylacetamide deacetylase. (399 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (268 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
SEC14L3SEC14-like protein 3-like isoform X1. (400 aa)
LOC102728215Complement C3-like. (768 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
HTR2B5-hydroxytryptamine receptor 2B. (526 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X2. (668 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (393 aa)
LOC102732272Ragulator complex protein LAMTOR1-like. (152 aa)
FITM2Fat storage-inducing transmembrane protein 2. (262 aa)
HNF4AHepatocyte nuclear factor 4-alpha. (399 aa)
CYR61Protein CYR61. (382 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein. (789 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
PTCHD2Patched domain-containing protein 2. (1393 aa)
ADRA2Aalpha-2A adrenergic receptor. (350 aa)
LOC102733378UPF0562 protein C7orf55 homolog. (113 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2435 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
FMO4Flavin-containing monooxygenase. (177 aa)
LOC102739094Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (841 aa)
LOC102738400Annexin. (345 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
ZFP69Zinc finger protein ZFP69. (522 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MFSD2AMajor facilitator superfamily domain-containing protein 2A isoform X1. (529 aa)
ZFP69BZinc finger protein ZFP69B. (534 aa)
PRMT3Protein arginine N-methyltransferase 3 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (529 aa)
PHB2Prohibitin. (299 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102735096Optic atrophy 3 protein-like. (186 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
HCAR1LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LOC102744936Fatty acid-binding protein, epidermal-like. (81 aa)
LOC102738981Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (143 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102733070Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (117 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102737780Uncharacterized protein KIAA0226-like. (230 aa)
LOC102740078Ragulator complex protein LAMTOR1-like. (98 aa)
LOC102746559Apolipoprotein B-100-like. (322 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
LOC102725895Ephrin type-A receptor 8-like. (743 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102726984Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like. (135 aa)
LOC102746352Lon protease homolog 2, peroxisomal-like; Belongs to the peptidase S16 family. (206 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa)
TYSND1Peroxisomal leader peptide-processing protease. (356 aa)
DKKL1Dickkopf-like protein 1 isoform X3. (237 aa)
LOC102734938Secretin-like. (108 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NR1H2Oxysterols receptor LXR-beta. (457 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
SEC14L5SEC14-like protein 5-like. (448 aa)
PSAPProsaposin isoform X1. (527 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
ABHD6Monoacylglycerol lipase ABHD6. (337 aa)
LOC102742922SEC14-like protein 5-like. (268 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
ARV1Protein ARV1. (281 aa)
DKK3Dickkopf-related protein 3. (286 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (447 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
DGKQDiacylglycerol kinase. (913 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DAGLBSn1-specific diacylglycerol lipase beta. (671 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LGALS12Galectin. (314 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (576 aa)
LOC102729166Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (134 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
TM6SF2Transmembrane 6 superfamily member 2. (376 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
LOC102747799Betatrophin. (198 aa)
SERPINA12Serpin A12; Belongs to the serpin family. (416 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PDE3BPhosphodiesterase. (1180 aa)
HTR2A5-hydroxytryptamine receptor 2A. (263 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
LONP2Lon protease homolog 2, peroxisomal. (660 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
PANK2Pantothenate kinase 2, mitochondrial isoform X1. (449 aa)
MBOAT7Lysophospholipid acyltransferase 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
SEC14L4SEC14-like protein 4 isoform X1. (406 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
SEC14L2SEC14-like protein 2 isoform X1. (403 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2. (486 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
DDX20Probable ATP-dependent RNA helicase DDX20. (823 aa)
PIBF1Progesterone-induced-blocking factor 1. (757 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5. (349 aa)
ABCD1ATP-binding cassette sub-family D member 1. (825 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (220 aa)
LOC10274629025-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (508 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102731486Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
THRSPThyroid hormone-inducible hepatic protein. (150 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
CCL19C-C motif chemokine. (100 aa)
CCL21c-C motif chemokine 21. (137 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
LOC102737090Sortilin-related receptor-like. (446 aa)
LOC102735400Optic atrophy 3 protein homolog. (141 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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