(36 nodes) Regulation of fatty acid metabolic process network (Leptonychotes weddellii)

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Predicted Interactions

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Your Input:
	TREX1	Three prime repair exonuclease 1. (314 aa)
	LOC102739775	Breast cancer type 1 susceptibility protein homolog. (471 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC102746352	Lon protease homolog 2, peroxisomal-like; Belongs to the peptidase S16 family. (206 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (303 aa)
	TYSND1	Peroxisomal leader peptide-processing protease. (356 aa)
	NR1H2	Oxysterols receptor LXR-beta. (457 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	LONP2	Lon protease homolog 2, peroxisomal. (660 aa)
	MID1IP1	Mid1-interacting protein 1. (183 aa)
	PRKAG2	5'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
	PANK2	Pantothenate kinase 2, mitochondrial isoform X1. (449 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	PIBF1	Progesterone-induced-blocking factor 1. (757 aa)
	ABCD1	ATP-binding cassette sub-family D member 1. (825 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	MFSD2A	Major facilitator superfamily domain-containing protein 2A isoform X1. (529 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	SLC45A3	Solute carrier family 45 member 3. (552 aa)
	LOC102738400	Annexin. (345 aa)
	LOC102739094	Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
	FMO4	Flavin-containing monooxygenase. (177 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X1. (2435 aa)
	PLA2G3	Group 3 secretory phospholipase A2. (522 aa)
	PDK4	Protein-serine/threonine kinase. (412 aa)
	METTL20	Methyltransferase-like protein 20. (266 aa)
	NR1H3	Oxysterols receptor LXR-alpha isoform X1. (456 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ABCD2	ATP-binding cassette sub-family D member 2 isoform X2. (742 aa)
	LOC102744936	Fatty acid-binding protein, epidermal-like. (81 aa)
	LOC102750518	Tribbles homolog 3-like. (215 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADVL	PDK2	A0A2U3Y5U4	A0A2U3YYT8	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Protein-serine/threonine kinase.	0.428
ACADVL	PDK4	A0A2U3Y5U4	A0A2U3XHB1	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Protein-serine/threonine kinase.	0.514
ACADVL	PPARA	A0A2U3Y5U4	A0A2U3Z257	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1.	Peroxisome proliferator-activated receptor alpha.	0.483
AKT1	AKT3	A0A2U3Y3V3	A0A2U3Y8K7	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.808
AKT1	INS	A0A2U3Y3V3	A0A2U3Z329	Non-specific serine/threonine protein kinase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.499
AKT1	LOC102739775	A0A2U3Y3V3	A0A2U3Z3N7	Non-specific serine/threonine protein kinase.	Breast cancer type 1 susceptibility protein homolog.	0.864
AKT1	LOC102750518	A0A2U3Y3V3	A0A2U3Z826	Non-specific serine/threonine protein kinase.	Tribbles homolog 3-like.	0.939
AKT3	AKT1	A0A2U3Y8K7	A0A2U3Y3V3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.808
AKT3	INS	A0A2U3Y8K7	A0A2U3Z329	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.499
AKT3	LOC102739775	A0A2U3Y8K7	A0A2U3Z3N7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog.	0.928
AKT3	LOC102750518	A0A2U3Y8K7	A0A2U3Z826	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tribbles homolog 3-like.	0.939
CAV1	INS	A0A2U3XCN0	A0A2U3Z329	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.540
FMO4	LOC102739094	A0A2U3XYA1	A0A2U3XYE5	Flavin-containing monooxygenase.	Dimethylaniline monooxygenase [N-oxide-forming].	0.803
INS	AKT1	A0A2U3Z329	A0A2U3Y3V3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.499
INS	AKT3	A0A2U3Z329	A0A2U3Y8K7	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.499
INS	CAV1	A0A2U3Z329	A0A2U3XCN0	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.540
INS	LOC102727345	A0A2U3Z329	A0A2U3YND0	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transcription factor SOX-9-like.	0.587
INS	LOC102739775	A0A2U3Z329	A0A2U3Z3N7	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Breast cancer type 1 susceptibility protein homolog.	0.493
INS	PDK4	A0A2U3Z329	A0A2U3XHB1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein-serine/threonine kinase.	0.487
INS	PPARA	A0A2U3Z329	A0A2U3Z257	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peroxisome proliferator-activated receptor alpha.	0.627