(43 nodes) Regulation of steroid metabolic process network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	SNAI1	Zinc finger protein SNAI1. (264 aa)
	ARMC5	Armadillo repeat-containing protein 5. (943 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	TTC39A	Tetratricopeptide repeat protein 39A isoform X3. (550 aa)
	FGFR4	Fibroblast growth factor receptor. (800 aa)
	SEC14L3	SEC14-like protein 3-like isoform X1. (400 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (393 aa)
	LOC102732272	Ragulator complex protein LAMTOR1-like. (152 aa)
	H6PD	GDH/6PGL endoplasmic bifunctional protein. (789 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
	LPCAT3	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
	LOC102731486	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	LOC102746290	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (508 aa)
	DDX20	Probable ATP-dependent RNA helicase DDX20. (823 aa)
	SEC14L2	SEC14-like protein 2 isoform X1. (403 aa)
	SEC14L4	SEC14-like protein 4 isoform X1. (406 aa)
	PANK2	Pantothenate kinase 2, mitochondrial isoform X1. (449 aa)
	SERPINA12	Serpin A12; Belongs to the serpin family. (416 aa)
	LDLR	Low-density lipoprotein receptor. (861 aa)
	LOC102747801	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	LOC102737823	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
	BMP6	Bone morphogenetic protein 6. (189 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	DGKQ	Diacylglycerol kinase. (913 aa)
	DKK3	Dickkopf-related protein 3. (286 aa)
	ARV1	Protein ARV1. (281 aa)
	LOC102742922	SEC14-like protein 5-like. (268 aa)
	SEC14L5	SEC14-like protein 5-like. (448 aa)
	DKKL1	Dickkopf-like protein 1 isoform X3. (237 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
	LOC102746559	Apolipoprotein B-100-like. (322 aa)
	LOC102740078	Ragulator complex protein LAMTOR1-like. (98 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP5	A0A2U3Z3S1	A0A2U3XA39	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 5 isoform X2.	0.497
BMP2	BMP6	A0A2U3Z3S1	A0A2U3YPC2	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 6.	0.924
BMP2	LOC102737823	A0A2U3Z3S1	A0A2U3YNM9	Bone morphogenetic protein 2-like.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.475
BMP2	LOC102744822	A0A2U3Z3S1	A0A2U3Z5B6	Bone morphogenetic protein 2-like.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.476
BMP2	LOC102747801	A0A2U3Z3S1	A0A2U3YLJ1	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
BMP2	TNF	A0A2U3Z3S1	A0A2U3Y499	Bone morphogenetic protein 2-like.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.451
BMP5	BMP2	A0A2U3XA39	A0A2U3Z3S1	Bone morphogenetic protein 5 isoform X2.	Bone morphogenetic protein 2-like.	0.497
BMP6	BMP2	A0A2U3YPC2	A0A2U3Z3S1	Bone morphogenetic protein 6.	Bone morphogenetic protein 2-like.	0.924
DHH	LDLR	A0A2U3XDA5	A0A2U3YKW3	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Low-density lipoprotein receptor.	0.465
EGR1	TNF	A0A2U3Y0M7	A0A2U3Y499	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.471
FGFR4	LOC102731486	A0A2U3XP14	A0A2U3Y7A7	Fibroblast growth factor receptor.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.474
FGFR4	LOC102737823	A0A2U3XP14	A0A2U3YNM9	Fibroblast growth factor receptor.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.955
FGFR4	LOC102744822	A0A2U3XP14	A0A2U3Z5B6	Fibroblast growth factor receptor.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.985
FGFR4	LOC102747801	A0A2U3XP14	A0A2U3YLJ1	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.955
IFNG	LOC102731864	A0A2U3Y8N2	A0A2U3Z7Y1	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription 5B-like.	0.603
IFNG	STAT5A	A0A2U3Y8N2	A0A2U3Z446	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription 5A.	0.651
IFNG	STAT5B	A0A2U3Y8N2	A0A2U3Y4J7	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription 5B.	0.603
IFNG	TNF	A0A2U3Y8N2	A0A2U3Y499	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.818
LDLR	DHH	A0A2U3YKW3	A0A2U3XDA5	Low-density lipoprotein receptor.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.465
LDLR	LOC102746559	A0A2U3YKW3	A0A2U3Z790	Low-density lipoprotein receptor.	Apolipoprotein B-100-like.	0.917