(22 nodes) Antigen processing and presentation of exogenous antigen network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102738001	T-cell surface glycoprotein CD1a-like. (339 aa)
	LOC102742806	T-cell surface glycoprotein CD1b-like. (349 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	LOC102746412	Replication protein A 32 kDa subunit-like. (124 aa)
	FCER1G	High affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
	LOC102749901	Gamma-interferon-inducible-lysosomal thiol reductase-like. (252 aa)
	LOC102733853	Antigen peptide transporter 2-like. (411 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	RPA4	LOW QUALITY PROTEIN: replication protein A4, 30kDa. (262 aa)
	CTSS	Cathepsin S isoform X1; Belongs to the peptidase C1 family. (340 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	MFSD6	Major facilitator superfamily domain-containing protein 6. (797 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TAP1	Antigen peptide transporter 1. (750 aa)
	LOC102747485	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2. (329 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	CLEC4A	LOW QUALITY PROTEIN: C-type lectin domain family 4 member A. (236 aa)
	PSME1	Proteasome activator complex subunit 1 isoform X1. (249 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	LOC102734456	A0A2U3X7R0	A0A2U3Z2X5	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.567
B2M	LOC102738001	A0A2U3X7R0	A0A2U3YB44	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD1a-like.	0.750
B2M	LOC102740784	A0A2U3X7R0	A0A2U3XXW2	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.592
B2M	LOC102741082	A0A2U3X7R0	A0A2U3XXW7	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.600
B2M	LOC102742806	A0A2U3X7R0	A0A2U3YB54	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD1b-like.	0.966
B2M	LOC102747485	A0A2U3X7R0	A0A2U3Y330	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2.	0.600
B2M	LOC102748462	A0A2U3X7R0	A0A2U3Y332	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO beta chain-like.	0.600
B2M	LOC102750166	A0A2U3X7R0	A0A2U3Y3B4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM beta chain-like.	0.597
B2M	LOC102750454	A0A2U3X7R0	A0A2U3Y337	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.540
CD74	CTSS	A0A2U3YC67	A0A2U3XA75	HLA class II histocompatibility antigen gamma chain.	Cathepsin S isoform X1; Belongs to the peptidase C1 family.	0.938
CD74	LOC102734456	A0A2U3YC67	A0A2U3Z2X5	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.923
CD74	LOC102740784	A0A2U3YC67	A0A2U3XXW2	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.996
CD74	LOC102741082	A0A2U3YC67	A0A2U3XXW7	HLA class II histocompatibility antigen gamma chain.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.987
CD74	LOC102747485	A0A2U3YC67	A0A2U3Y330	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2.	0.791
CD74	LOC102748462	A0A2U3YC67	A0A2U3Y332	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DO beta chain-like.	0.976
CD74	LOC102750166	A0A2U3YC67	A0A2U3Y3B4	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DM beta chain-like.	0.963
CD74	LOC102750454	A0A2U3YC67	A0A2U3Y337	HLA class II histocompatibility antigen gamma chain.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.977
CLEC4A	FCER1G	A0A2U3Y3K1	A0A2U3YL68	LOW QUALITY PROTEIN: C-type lectin domain family 4 member A.	High affinity immunoglobulin epsilon receptor subunit gamma.	0.771
CTSS	CD74	A0A2U3XA75	A0A2U3YC67	Cathepsin S isoform X1; Belongs to the peptidase C1 family.	HLA class II histocompatibility antigen gamma chain.	0.938
CTSS	TRAF6	A0A2U3XA75	A0A2U3XYU7	Cathepsin S isoform X1; Belongs to the peptidase C1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.520