(26 nodes) Lipid storage network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HEXB	Beta-hexosaminidase. (527 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
	GBA	Glucosylceramidase. (536 aa)
	FITM2	Fat storage-inducing transmembrane protein 2. (262 aa)
	SOAT1	O-acyltransferase. (484 aa)
	CRY1	Cryptochrome-1. (587 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	FITM1	Fat storage-inducing transmembrane protein 1. (292 aa)
	SQLE	Squalene monooxygenase. (573 aa)
	PNPLA2	Patatin-like phospholipase domain-containing protein 2. (486 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (437 aa)
	FFAR2	Free fatty acid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (329 aa)
	LRRN4CL	LRRN4 C-terminal-like protein. (237 aa)
	TMEM159	Promethin isoform X1. (161 aa)
	NRIP1	Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)
	AUP1	LOW QUALITY PROTEIN: ancient ubiquitous protein 1. (438 aa)
	BSCL2	Seipin isoform X2. (394 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CDS1	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
	SMIM22	Small integral membrane protein 22. (91 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	CRY2	Cryptochrome-2. (527 aa)
	LOC102732118	UPF0554 protein C2orf43 homolog isoform X1. (325 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	DGAT1	O-acyltransferase. (495 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUP1	CDS1	A0A2U3XV97	A0A2U3YUG4	LOW QUALITY PROTEIN: ancient ubiquitous protein 1.	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	0.695
BSCL2	DGAT1	A0A2U3XGF4	A0A2U3YRK1	Seipin isoform X2.	O-acyltransferase.	0.489
BSCL2	FITM1	A0A2U3XGF4	A0A2U3Y4R7	Seipin isoform X2.	Fat storage-inducing transmembrane protein 1.	0.594
BSCL2	FITM2	A0A2U3XGF4	A0A2U3XSW5	Seipin isoform X2.	Fat storage-inducing transmembrane protein 2.	0.597
BSCL2	PLIN2	A0A2U3XGF4	A0A2U3YE88	Seipin isoform X2.	Perilipin; Belongs to the perilipin family.	0.500
BSCL2	PNPLA2	A0A2U3XGF4	A0A2U3YCF5	Seipin isoform X2.	Patatin-like phospholipase domain-containing protein 2.	0.482
CAV1	TNF	A0A2U3XCN0	A0A2U3Y499	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.432
CDS1	AUP1	A0A2U3YUG4	A0A2U3XV97	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	LOW QUALITY PROTEIN: ancient ubiquitous protein 1.	0.695
CDS1	SQLE	A0A2U3YUG4	A0A2U3Y7N8	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	Squalene monooxygenase.	0.540
CRY1	CRY2	A0A2U3XIF4	A0A2U3Z576	Cryptochrome-1.	Cryptochrome-2.	0.996
CRY2	CRY1	A0A2U3Z576	A0A2U3XIF4	Cryptochrome-2.	Cryptochrome-1.	0.996
DGAT1	BSCL2	A0A2U3YRK1	A0A2U3XGF4	O-acyltransferase.	Seipin isoform X2.	0.489
DGAT1	PLIN2	A0A2U3YRK1	A0A2U3YE88	O-acyltransferase.	Perilipin; Belongs to the perilipin family.	0.588
DGAT1	PNPLA2	A0A2U3YRK1	A0A2U3YCF5	O-acyltransferase.	Patatin-like phospholipase domain-containing protein 2.	0.920
FITM1	BSCL2	A0A2U3Y4R7	A0A2U3XGF4	Fat storage-inducing transmembrane protein 1.	Seipin isoform X2.	0.594
FITM2	BSCL2	A0A2U3XSW5	A0A2U3XGF4	Fat storage-inducing transmembrane protein 2.	Seipin isoform X2.	0.597
FITM2	PLIN2	A0A2U3XSW5	A0A2U3YE88	Fat storage-inducing transmembrane protein 2.	Perilipin; Belongs to the perilipin family.	0.486
LOC102731864	STAT5A	A0A2U3Z7Y1	A0A2U3Z446	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5A.	0.948
LOC102731864	STAT5B	A0A2U3Z7Y1	A0A2U3Y4J7	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5B.	0.947
PLIN2	BSCL2	A0A2U3YE88	A0A2U3XGF4	Perilipin; Belongs to the perilipin family.	Seipin isoform X2.	0.500