(40 nodes) Digestive system process network (Leptonychotes weddellii)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F11R	Junctional adhesion molecule A. (298 aa)
	LOC102734167	Neurogenin-1-like. (250 aa)
	PBLD	Phenazine biosynthesis-like domain-containing protein. (255 aa)
	LOC102732556	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
	TWF2	Toll-like receptor 9-like isoform X1. (1331 aa)
	LOC102741867	Villin-1-like. (505 aa)
	LOC102738856	Villin-like protein-like. (205 aa)
	LOC102732141	Iron-responsive element-binding protein 2-like. (229 aa)
	VSIG1	V-set and immunoglobulin domain-containing protein 1. (411 aa)
	VIL1	Villin-1. (330 aa)
	IL17A	interleukin-17A. (155 aa)
	TFF3	Trefoil factor 3. (80 aa)
	AQP1	Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	TIFAB	TRAF-interacting protein with FHA domain-containing protein B. (166 aa)
	ZNF830	Zinc finger protein 830. (371 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	LDLR	Low-density lipoprotein receptor. (861 aa)
	CEL	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (607 aa)
	UCN	Urocortin. (126 aa)
	SLC26A7	Anion exchange transporter. (656 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	VILL	Villin-like protein-like. (375 aa)
	FABP2	Fatty acid-binding protein, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	GHRL	Appetite-regulating hormone isoform X1. (117 aa)
	STRAP	Serine-threonine kinase receptor-associated protein isoform X1. (350 aa)
	SLC9A4	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (636 aa)
	NPC1L1	niemann-Pick C1-like protein 1. (1331 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
	NPC1	niemann-Pick C1 protein. (1276 aa)
	UGCG	Ceramide glucosyltransferase. (275 aa)
	CCKBR	Gastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	HRH2	Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	PLS1	Plastin-1. (604 aa)
	SNX10	Sorting nexin-10. (201 aa)
	KIAA1211	Uncharacterized protein KIAA1211 homolog. (1224 aa)
	CHRM5	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
	CHRM1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
	VDR	Vitamin D3 receptor. (427 aa)
	ACO1	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (889 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO1	LOC102732141	A0A2U3X7H5	A0A2U3Z1E9	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family.	Iron-responsive element-binding protein 2-like.	0.475
CCKBR	HRH2	A0A2U3XMS9	A0A2U3XM60	Gastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family.	Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family.	0.428
CHRM1	CHRM5	A0A2U3XG22	A0A2U3XGU0	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.897
CHRM1	GHRL	A0A2U3XG22	A0A2U3Y5Q3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Appetite-regulating hormone isoform X1.	0.830
CHRM1	LOC102732556	A0A2U3XG22	A0A2U3Z6H1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.896
CHRM5	CHRM1	A0A2U3XGU0	A0A2U3XG22	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.897
CHRM5	GHRL	A0A2U3XGU0	A0A2U3Y5Q3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Appetite-regulating hormone isoform X1.	0.454
CHRM5	LOC102732556	A0A2U3XGU0	A0A2U3Z6H1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.896
GHRL	CHRM1	A0A2U3Y5Q3	A0A2U3XG22	Appetite-regulating hormone isoform X1.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.830
GHRL	CHRM5	A0A2U3Y5Q3	A0A2U3XGU0	Appetite-regulating hormone isoform X1.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.454
GHRL	LEP	A0A2U3Y5Q3	A0A2U3YW34	Appetite-regulating hormone isoform X1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.979
GHRL	LOC102732556	A0A2U3Y5Q3	A0A2U3Z6H1	Appetite-regulating hormone isoform X1.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.460
GHRL	UCN	A0A2U3Y5Q3	A0A2U3YJ11	Appetite-regulating hormone isoform X1.	Urocortin.	0.571
HRH2	CCKBR	A0A2U3XM60	A0A2U3XMS9	Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family.	Gastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family.	0.428
IL17A	LEP	A0A2U3YYK4	A0A2U3YW34	interleukin-17A.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.470
IL17A	NOD2	A0A2U3YYK4	A0A2U3YF51	interleukin-17A.	Nucleotide-binding oligomerization domain-containing protein 2.	0.487
IL17A	TWF2	A0A2U3YYK4	A0A2U3Z4Z0	interleukin-17A.	Toll-like receptor 9-like isoform X1.	0.504
LEP	GHRL	A0A2U3YW34	A0A2U3Y5Q3	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Appetite-regulating hormone isoform X1.	0.979
LEP	IL17A	A0A2U3YW34	A0A2U3YYK4	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	interleukin-17A.	0.470
LEP	VDR	A0A2U3YW34	A0A2U3XDE3	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Vitamin D3 receptor.	0.492